Single unit activity of periaqueductal gray and deep mesencephalic nucleus neurons involved in sleep stage switching in the mouse

2018 ◽  
Vol 47 (9) ◽  
pp. 1110-1126 ◽  
Author(s):  
K. Sakai
Keyword(s):  
Unit Activity ◽  
Single Unit ◽  
Sleep Stage ◽  
Periaqueductal Gray ◽  
Single Unit Activity ◽  
Deep Mesencephalic Nucleus

scholarly journals Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Kristina M Wright ◽  
Michael A McDannald
Keyword(s):  
Unit Activity ◽  
Single Unit ◽  
Periaqueductal Gray ◽  
Single Unit Activity ◽  
Shock Delivery ◽  
Auditory Cues ◽  
Potential Harm ◽  
Reward Seeking ◽  
Probability Estimates ◽  
Prevailing View

Faced with potential harm, individuals must estimate the probability of threat and initiate an appropriate fear response. In the prevailing view, threat probability estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fear output. A straightforward prediction is that vlPAG single-unit activity reflects fear output, invariant of threat probability. We recorded vlPAG single-unit activity in male, Long Evans rats undergoing fear discrimination. Three 10 s auditory cues predicted unique foot shock probabilities: danger (p=1.00), uncertainty (p=0.375) and safety (p=0.00). Fear output was measured by suppression of reward seeking over the entire cue and in one-second cue intervals. Cued fear non-linearly scaled to threat probability and cue-responsive vlPAG single-units scaled their firing on one of two timescales: at onset or ramping toward shock delivery. VlPAG onset activity reflected threat probability, invariant of fear output, while ramping activity reflected both signals with threat probability prioritized.

Effect of Eye Opening on Single-Unit Activity and Local Field Potentials in the Subthalamic Nucleus

2017 ◽  
Vol 20 (5) ◽  
pp. 471-477 ◽  
Author(s):  
Arun Chockalingam ◽  
Abigail Belasen ◽  
Nita Chen ◽  
Adolfo Ramirez-Zamora ◽  
Youngwon Youn ◽  
...  
Keyword(s):  
Subthalamic Nucleus ◽  
Local Field ◽  
Unit Activity ◽  
Single Unit ◽  
Local Field Potentials ◽  
Single Unit Activity ◽  
Field Potentials ◽  
Eye Opening
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