Effect of Eye Opening on Single-Unit Activity and Local Field Potentials in the Subthalamic Nucleus

2017 ◽  
Vol 20 (5) ◽  
pp. 471-477 ◽  
Author(s):  
Arun Chockalingam ◽  
Abigail Belasen ◽  
Nita Chen ◽  
Adolfo Ramirez-Zamora ◽  
Youngwon Youn ◽  
...  
Keyword(s):  
Subthalamic Nucleus ◽  
Local Field ◽  
Unit Activity ◽  
Single Unit ◽  
Local Field Potentials ◽  
Single Unit Activity ◽  
Field Potentials ◽  
Eye Opening

scholarly journals Single-unit activity, threshold crossings, and local field potentials in motor cortex differentially encode reach kinematics

2015 ◽  
Vol 114 (3) ◽  
pp. 1500-1512 ◽  
Author(s):  
Sagi Perel ◽  
Patrick T. Sadtler ◽  
Emily R. Oby ◽  
Stephen I. Ryu ◽  
Elizabeth C. Tyler-Kabara ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Local Field ◽  
Unit Activity ◽  
Single Unit ◽  
Primary Motor Cortex ◽  
Spatial Scales ◽  
Local Field Potentials ◽  
Single Unit Activity ◽  
Field Potentials ◽  
Threshold Crossing

A diversity of signals can be recorded with extracellular electrodes. It remains unclear whether different signal types convey similar or different information and whether they capture the same or different underlying neural phenomena. Some researchers focus on spiking activity, while others examine local field potentials, and still others posit that these are fundamentally the same signals. We examined the similarities and differences in the information contained in four signal types recorded simultaneously from multielectrode arrays implanted in primary motor cortex: well-isolated action potentials from putative single units, multiunit threshold crossings, and local field potentials (LFPs) at two distinct frequency bands. We quantified the tuning of these signal types to kinematic parameters of reaching movements. We found 1) threshold crossing activity is not a proxy for single-unit activity; 2) when examined on individual electrodes, threshold crossing activity more closely resembles LFP activity at frequencies between 100 and 300 Hz than it does single-unit activity; 3) when examined across multiple electrodes, threshold crossing activity and LFP integrate neural activity at different spatial scales; and 4) LFP power in the “beta band” (between 10 and 40 Hz) is a reliable indicator of movement onset but does not encode kinematic features on an instant-by-instant basis. These results show that the diverse signals recorded from extracellular electrodes provide somewhat distinct and complementary information. It may be that these signal types arise from biological phenomena that are partially distinct. These results also have practical implications for harnessing richer signals to improve brain-machine interface control.

scholarly journals Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces

2018 ◽  
Vol 63 (3) ◽  
pp. 301-315 ◽  
Author(s):  
Richárd Fiáth ◽  
Katharina T. Hofer ◽  
Vivien Csikós ◽  
Domonkos Horváth ◽  
Tibor Nánási ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Local Field ◽  
Unit Activity ◽  
Single Unit ◽  
Local Field Potentials ◽  
Field Potential ◽  
Tissue Reaction ◽  
Field Potentials ◽  
Depth Electrodes

Abstract Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6–12 macro- or microelectrodes), limited spatial resolution (0.5–1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices. The cylindrically-shaped depth probes made of polyimide (PI) were chronically implanted for 13 weeks into the brain of rats, while cortical or thalamic activity (local field potentials, single-unit and multi-unit activity) was recorded regularly to monitor the temporal change of several features of the electrophysiological performance. To examine the tissue reaction around the probe, neuron-selective and astroglia-selective immunostaining methods were applied. Stable single-unit and multi-unit activity were recorded for several weeks with the implanted depth probes and a weak or moderate tissue reaction was found around the probe track. Our data on biocompatibility presented here and in vivo experiments in non-human primates provide a strong indication that this type of neural probe can be applied in stereo-electroencephalography recordings of up to 2 weeks in humans targeting the localization of epileptic foci providing an increased spatial resolution and the ability to monitor local field potentials and neuronal spiking activity.

scholarly journals Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy

Epilepsia ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Shennan Aibel Weiss ◽  
Catalina Alvarado-Rojas ◽  
Anatol Bragin ◽  
Eric Behnke ◽  
Tony Fields ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Local Field ◽  
Unit Activity ◽  
High Frequency ◽  
Local Field Potentials ◽  
Mesial Temporal Lobe Epilepsy ◽  
Field Potentials ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe
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