The resting-state neurovascular coupling relationship: rapid changes in spontaneous neural activity in the somatosensory cortex are associated with haemodynamic fluctuations that resemble stimulus-evoked haemodynamics

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Michael Bruyns-Haylett ◽  
Sam Harris ◽  
Luke Boorman ◽  
Ying Zheng ◽  
Jason Berwick ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Neural Activity ◽  
Resting State ◽  
Neurovascular Coupling ◽  
Coupling Relationship ◽  
Spontaneous Neural Activity ◽  
Rapid Changes

scholarly journals Disrupted Spontaneous Neural Activity in Patients With Thyroid-Associated Ophthalmopathy: A Resting-State fMRI Study Using Amplitude of Low-Frequency Fluctuation

2021 ◽  
Vol 15 ◽  
Author(s):  
Wen Chen ◽  
Qian Wu ◽  
Lu Chen ◽  
Jiang Zhou ◽  
Huan-Huan Chen ◽  
...  
Keyword(s):  
Neural Activity ◽  
Resting State ◽  
Low Frequency ◽  
Occipital Lobe ◽  
Frequency Fluctuation ◽  
Clinical Activity ◽  
Spontaneous Neural Activity ◽  
Thyroid Associated Ophthalmopathy ◽  
Middle Occipital Gyrus ◽  
Left Middle

PurposeThe purpose of the study was to investigate the brain functional alteration in patients with thyroid-associated ophthalmopathy (TAO) by evaluating the spontaneous neural activity changes using resting-state functional magnetic resonance imaging (rs-fMRI) with the amplitude of low-frequency fluctuation (ALFF) method.Materials and MethodsThe rs-fMRI data of 30 TAO patients (15 active and 15 inactive) and 15 healthy controls (HCs) were included for analyses. The ALFF values were calculated and compared among groups. Correlations between ALFF values and clinical metrics were assessed.ResultsCompared with HCs, active TAOs showed significantly decreased ALFF values in the left middle occipital gyrus, superior occipital gyrus, and cuneus. Compared with inactive TAOs, active TAOs showed significantly increased ALFF values in the bilateral precuneus. Additionally, inactive TAOs showed significantly decreased ALFF values in the left middle occipital gyrus, superior occipital gyrus, cuneus, and bilateral precuneus than HCs. The ALFF value in the right precuneus of TAOs was positively correlated with clinical activity score (r = 0.583, P < 0.001) and Mini-Mental State Examination (MMSE) score (r = 0.377, P = 0.040), and negatively correlated with disease duration (r = −0.382, P = 0.037). Moreover, the ALFF value in the left middle occipital gyrus of TAOs was positively correlated with visual acuity (r = 0.441, P = 0.015).ConclusionTAO patients had altered spontaneous brain activities in the left occipital lobe and bilateral precuneus. The neuropsychological aspect of the disease should be noticed during clinical diagnosis and treatment.

scholarly journals Spontaneous neural activity differences in posttraumatic stress disorder: A quantitative resting‐state meta‐analysis and fMRI validation

2017 ◽  
Vol 39 (2) ◽  
pp. 837-850 ◽  
Author(s):  
Seth G. Disner ◽  
Craig A. Marquardt ◽  
Bryon A. Mueller ◽  
Philip C. Burton ◽  
Scott R. Sponheim
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Neural Activity ◽  
Resting State ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Spontaneous Neural Activity

scholarly journals Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging

2016 ◽  
Vol 124 (1) ◽  
pp. 159-168 ◽  
Author(s):  
Vishvarani Wanigasekera ◽  
Melvin Mezue ◽  
Jesper Andersson ◽  
Yazhuo Kong ◽  
Irene Tracey
Keyword(s):  
Neuropathic Pain ◽  
Functional Connectivity ◽  
Drug Development ◽  
Somatosensory Cortex ◽  
Outcome Measures ◽  
Neural Activity ◽  
Resting State ◽  
Central Sensitization ◽  
Resting State Functional Connectivity ◽  
Secondary Somatosensory Cortex

Abstract Background Attrition rates of new analgesics during drug development are high; poor assay sensitivity with reliance on subjective outcome measures being a crucial factor. Methods The authors assessed the utility of functional magnetic resonance imaging with capsaicin-induced central sensitization, a mechanism relevant in neuropathic pain, for obtaining mechanism-based objective outcome measures that can differentiate an effective analgesic (gabapentin) from an ineffective analgesic (ibuprofen) and both from placebo. The authors used a double-blind, randomized phase I study design (N = 24) with single oral doses. Results Only gabapentin suppressed the secondary mechanical hyperalgesia–evoked neural response in a region of the brainstem’s descending pain modulatory system (right nucleus cuneiformis) and left (contralateral) posterior insular cortex and secondary somatosensory cortex. Similarly, only gabapentin suppressed the resting-state functional connectivity during central sensitization between the thalamus and secondary somatosensory cortex, which was plasma gabapentin level dependent. A power analysis showed that with 12 data sets, when using neural activity from the left posterior insula and right nucleus cuneiformis, a statistically significant difference between placebo and gabapentin was detected with probability ≥ 0.8. When using subjective pain ratings, this reduced to less than or equal to 0.6. Conclusions Functional imaging with central sensitization can be used as a sensitive mechanism–based assay to guide go/no-go decisions on selecting analgesics effective in neuropathic pain in early human drug development. We also show analgesic modulation of neural activity by using resting-state functional connectivity, a less challenging paradigm that is ideally suited for patient studies because it requires no task or pain provocation.

scholarly journals Spontaneous Neural Activity Changes after Bariatric Surgery: a resting-state fMRI study

NeuroImage ◽  
2021 ◽  
pp. 118419
Author(s):  
Yashar Zeighami ◽  
Sylvain Iceta ◽  
Mahsa Dadar ◽  
Mélissa Pelletier ◽  
Mélanie Nadeau ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Neural Activity ◽  
Resting State ◽  
Resting State Fmri ◽  
Spontaneous Neural Activity ◽  
Fmri Study
Sign in / Sign up

Export Citation Format

Share Document