Right Heart and Pulmonary Vessels Structure and Function

2014 ◽  
Vol 32 ◽  
pp. S3-S10 ◽  
Author(s):  
Michele D'Alto ◽  
Giancarlo Scognamiglio ◽  
Kostantinos Dimopoulos ◽  
Eduardo Bossone ◽  
Dario Vizza ◽  
...  
Keyword(s):  
Structure And Function ◽  
Right Heart ◽  
Pulmonary Vessels ◽  
And Function

Novel Methods for Assessment of Right Heart Structure and Function in Pulmonary Hypertension

2012 ◽  
Vol 39 (3) ◽  
pp. 685-701 ◽  
Author(s):  
Gautam K. Singh ◽  
Philip T. Levy ◽  
Mark R. Holland ◽  
Aaron Hamvas
Keyword(s):  
Pulmonary Hypertension ◽  
Structure And Function ◽  
Right Heart ◽  
Novel Methods ◽  
And Function

scholarly journals Genetic Analysis of Right Heart Structure and Function in 40,000 People

2021 ◽  
Author(s):  
James P. Pirruccello ◽  
Paolo Di Achille ◽  
Victor Nauffal ◽  
Mahan Nekoui ◽  
Samuel N. Friedman ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Deep Learning ◽  
Right Ventricular ◽  
Congenital Heart ◽  
Left Ventricular ◽  
Structure And Function ◽  
Right Heart ◽  
Heart Chamber ◽  
The Right ◽  
And Function

The heart evolved hundreds of millions of years ago. During mammalian evolution, the cardiovascular system developed with complete separation between pulmonary and systemic circulations incorporated into a single pump with chambers dedicated to each circulation. A lower pressure right heart chamber supplies deoxygenated blood to the lungs, while a high pressure left heart chamber supplies oxygenated blood to the rest of the body. Due to the complexity of morphogenic cardiac looping and septation required to form these two chambers, congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. Additionally, some diseases predominantly affect structures of the right heart, including arrhythmogenic right ventricular cardiomyopathy (ARVC) and pulmonary hypertension. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize the right atrium, the right ventricle, and the pulmonary artery, and then used those models to measure right heart structures in over 40,000 individuals from the UK Biobank with magnetic resonance imaging. We found associations between these measurements and clinical disease including pulmonary hypertension and dilated cardiomyopathy. We then conducted genome-wide association studies, identifying 104 distinct loci associated with at least one right heart measurement. Several of these loci were found near genes previously linked with congenital heart disease, such as NKX2-5, TBX3, WNT9B, and GATA4. We also observed interesting commonalities and differences in association patterns at genetic loci linked with both right and left ventricular measurements. Finally, we found that a polygenic predictor of right ventricular end systolic volume was associated with incident dilated cardiomyopathy (HR 1.28 per standard deviation; P = 2.4E-10), and remained a significant predictor of disease even after accounting for a left ventricular polygenic score. Harnessing deep learning to perform large-scale cardiac phenotyping, our results yield insights into the genetic and clinical determinants of right heart structure and function.

The Normal Impact of Age and Gender on Right Heart Structure and Function

2013 ◽  
Vol 31 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Michael Henein ◽  
Anders Waldenström ◽  
Stellan Mörner ◽  
Per Lindqvist
Keyword(s):  
Structure And Function ◽  
Normal Impact ◽  
Right Heart ◽  
Age And Gender ◽  
And Gender ◽  
And Function

scholarly journals Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

2022 ◽  
Author(s):  
Alexey N. Sumin ◽  
Nina S. Gomozova ◽  
Anna V. Shcheglova ◽  
Oleg G. Arkhipov
Keyword(s):  
Arterial Hypertension ◽  
Right Ventricular ◽  
Diastolic Dysfunction ◽  
Ethnic Differences ◽  
Structure And Function ◽  
Right Heart ◽  
Hypertensive Patients ◽  
Factors Associated ◽  
The Right ◽  
And Function

Abstract Objective of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. Methods The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38), non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Results Shor men with arterial hypertension had the lowest values ​​of the pulmonary artery index, the right atrium dimensions, and the highest values ​​of the blood flow velocity in the right ventricle, et' and st' in comparison with non-indigenous men. Shor women have the lowest values Et and Et/At ratios. RV diastolic dysfunction was detected mainly in women, somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence. Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Conclusion Our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

scholarly journals Influence of obstructive sleep apnea on right heart structure and function

2021 ◽  
Vol 89 (5) ◽  
pp. 493-500
Author(s):  
Michał Harańczyk ◽  
Małgorzata Konieczyńska ◽  
Wojciech Płazak
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Structure And Function ◽  
Right Heart ◽  
Obstructive Sleep ◽  
And Function

The right ventricle in critical illness

2017 ◽  
Author(s):  
Claire Colebourn ◽  
Jim Newton
Keyword(s):  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Heart Function ◽  
Structure And Function ◽  
Care Practice ◽  
Right Heart ◽  
Right Heart Function ◽  
Ventricular Structure ◽  
The Right ◽  
And Function

This chapter describes the unique aspects of right ventricular structure and function and relates this to the effects of an acute or chronic rise in pulmonary vascular resistance on the right heart. Assessment of pulmonary vascular resistance and right heart function is described in detail. The usage of this assessment in critical care practice is then explored, with particular reference to mechanical ventilation and pulmonary embolism.

scholarly journals Erratum to: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice

2011 ◽  
Vol 11 (S1) ◽  
Author(s):  
Wiebke Janssen ◽  
Yves Schymura ◽  
Astrid Wietelmann ◽  
Johannes-Peter Stasch ◽  
Himal Luitel ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Structure And Function ◽  
Right Heart ◽  
And Function

scholarly journals Cardiac structure and function in lowlanders at high altitude: short-term adaptation and chronic remodeling

2021 ◽  
Author(s):  
guyue liu ◽  
liming zhao ◽  
qing xu ◽  
rong xiao ◽  
mingjian lang
Keyword(s):  
Sea Level ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Short Term ◽  
Right Heart ◽  
Short Term Exposure ◽  
Short Term Adaptation ◽  
Cardiac Structure And Function ◽  
And Function

Aims: The purpose of this study was to examine cardiac structure and function in lowlanders at high altitude(HA) to investigate short-term adaptation and long-term cardiac remodeling. Methods: In total of 301 healthy subjects included in this study, short-term exposed (STE) and acclimatized lowlanders (AL) at HA, native Tibetans(NT) and sea level residents(SLR) were comprised of 75,77,69 and 80 participants, respectively. Standard echocardiography was performed on all groups, subjects at HA were examined after return to sea level in <24 hours. Results: SBP and HR did not increase significantly after short-term exposure to HA in STE, but increased after long-term exposure in AL, which could be detected even after returning to the plain. Exposure to HA enlarged right heart, widened pulmonary artery and reduced left ventricular(LV) diastolic function in lowlanders. The degree of diastolic dysfunction was more obvious in AL. LV wall thickness increased even after short-term exposure to HA in lowlanders. Ejection fraction did not change significantly in STE, but decreased in AL. Conclusions: Exposure to HA could enlarged the right heart and decrease the diastolic function of LV in lowlanders. The LV systolic function was preserved after short-term HA exposure, but decreased after long-term HA exposure.

scholarly journals Improvement of right heart structure and function by BAY 41-8543 in pulmonary artery banded mice

2011 ◽  
Vol 11 (S1) ◽  
Author(s):  
Wiebke Janssen ◽  
Yves Schymura ◽  
Astrid Wietelmann ◽  
Johannes-Peter Stasch ◽  
Himal Luitel ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Structure And Function ◽  
Right Heart ◽  
And Function
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