Novel Methods for Assessment of Right Heart Structure and Function in Pulmonary Hypertension

2012 ◽  
Vol 39 (3) ◽  
pp. 685-701 ◽  
Author(s):  
Gautam K. Singh ◽  
Philip T. Levy ◽  
Mark R. Holland ◽  
Aaron Hamvas
Keyword(s):  
Pulmonary Hypertension ◽  
Structure And Function ◽  
Right Heart ◽  
Novel Methods ◽  
And Function

scholarly journals Genetic Analysis of Right Heart Structure and Function in 40,000 People

2021 ◽  
Author(s):  
James P. Pirruccello ◽  
Paolo Di Achille ◽  
Victor Nauffal ◽  
Mahan Nekoui ◽  
Samuel N. Friedman ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Deep Learning ◽  
Right Ventricular ◽  
Congenital Heart ◽  
Left Ventricular ◽  
Structure And Function ◽  
Right Heart ◽  
Heart Chamber ◽  
The Right ◽  
And Function

The heart evolved hundreds of millions of years ago. During mammalian evolution, the cardiovascular system developed with complete separation between pulmonary and systemic circulations incorporated into a single pump with chambers dedicated to each circulation. A lower pressure right heart chamber supplies deoxygenated blood to the lungs, while a high pressure left heart chamber supplies oxygenated blood to the rest of the body. Due to the complexity of morphogenic cardiac looping and septation required to form these two chambers, congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. Additionally, some diseases predominantly affect structures of the right heart, including arrhythmogenic right ventricular cardiomyopathy (ARVC) and pulmonary hypertension. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize the right atrium, the right ventricle, and the pulmonary artery, and then used those models to measure right heart structures in over 40,000 individuals from the UK Biobank with magnetic resonance imaging. We found associations between these measurements and clinical disease including pulmonary hypertension and dilated cardiomyopathy. We then conducted genome-wide association studies, identifying 104 distinct loci associated with at least one right heart measurement. Several of these loci were found near genes previously linked with congenital heart disease, such as NKX2-5, TBX3, WNT9B, and GATA4. We also observed interesting commonalities and differences in association patterns at genetic loci linked with both right and left ventricular measurements. Finally, we found that a polygenic predictor of right ventricular end systolic volume was associated with incident dilated cardiomyopathy (HR 1.28 per standard deviation; P = 2.4E-10), and remained a significant predictor of disease even after accounting for a left ventricular polygenic score. Harnessing deep learning to perform large-scale cardiac phenotyping, our results yield insights into the genetic and clinical determinants of right heart structure and function.

The Normal Impact of Age and Gender on Right Heart Structure and Function

2013 ◽  
Vol 31 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Michael Henein ◽  
Anders Waldenström ◽  
Stellan Mörner ◽  
Per Lindqvist
Keyword(s):  
Structure And Function ◽  
Normal Impact ◽  
Right Heart ◽  
Age And Gender ◽  
And Gender ◽  
And Function

scholarly journals Right ventricular function in infants with bronchopulmonary dysplasia and pulmonary hypertension: a pilot study

2018 ◽  
Vol 9 (1) ◽  
pp. 204589401881606 ◽  
Author(s):  
Arabella J. Blanca ◽  
Liesbeth Duijts ◽  
Esther van Mastrigt ◽  
Marielle W. Pijnenburg ◽  
Derk-Jan D. Ten Harkel ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Bronchopulmonary Dysplasia ◽  
Gestational Age ◽  
Circumferential Strain ◽  
Systolic Function ◽  
Structure And Function ◽  
Systolic Strain ◽  
Cardiac Structure And Function ◽  
Myocardial Structure ◽  
And Function

Premature birth and bronchopulmonary dysplasia (BPD) are risk factors for the development of echocardiographic signs of pulmonary hypertension (PH) and are associated with changes in cardiac structure and function. It is unclear whether this association persists beyond early infancy. The aims of this study are to prospectively investigate the prevalence of PH in children with severe BPD and to investigate the effect of BPD and PH on myocardial structure and function at six months corrected age. Preterm infants (gestational age ≤ 32 weeks) with severe BPD were included. Echocardiography was used to define PH and to measure speckle tracking derived longitudinal and circumferential strain of the left ventricle (LV) and right ventricle (RV). Sixty-nine infants with a median (interquartile range [IQR]) gestational age of 25.6 (24.9–26.4) weeks and a median birthweight of 770 (645–945) gram were included. Eight (12%) infants had signs of PH at six months corrected age. RV fractional area change was lower in infants with severe BPD and PH at six months compared to infants without PH (35% ± 9% vs. 43% ± 9%, P = 0.03). RV mean longitudinal systolic strain was lower in infants with severe BPD and PH compared to infants without PH (17.6% [−19.5%/−16.1%] vs. −20.9% [−25.9%/−17.9%], P = 0.04). RV size and LV longitudinal and circumferential strain in children with BPD with or without PH were similar. Signs of PH were found in 12% of infants with severe BPD at six months corrected age and the presence of PH is associated with reduced RV systolic function.

scholarly journals NT-proBNP reflects right ventricular structure and function in pulmonary hypertension

2006 ◽  
Vol 28 (6) ◽  
pp. 1190-1194 ◽  
Author(s):  
C. T. Gan ◽  
G. P. McCann ◽  
J. T. Marcus ◽  
S. A. van Wolferen ◽  
J. W. Twisk ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Structure And Function ◽  
Ventricular Structure ◽  
And Function

scholarly journals Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

2022 ◽  
Author(s):  
Alexey N. Sumin ◽  
Nina S. Gomozova ◽  
Anna V. Shcheglova ◽  
Oleg G. Arkhipov
Keyword(s):  
Arterial Hypertension ◽  
Right Ventricular ◽  
Diastolic Dysfunction ◽  
Ethnic Differences ◽  
Structure And Function ◽  
Right Heart ◽  
Hypertensive Patients ◽  
Factors Associated ◽  
The Right ◽  
And Function

Abstract Objective of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. Methods The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38), non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Results Shor men with arterial hypertension had the lowest values ​​of the pulmonary artery index, the right atrium dimensions, and the highest values ​​of the blood flow velocity in the right ventricle, et' and st' in comparison with non-indigenous men. Shor women have the lowest values Et and Et/At ratios. RV diastolic dysfunction was detected mainly in women, somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence. Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Conclusion Our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

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