Decreased serum levels of interleukin‐17, interleukin‐23, TGF ‐β in pemphigus vulgaris patients, and their association with disease phase

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Zeinab Gholibeigian ◽  
Maryam Izad ◽  
Maryam Daneshpazhooh ◽  
Hossein Mortazavi ◽  
Zahra Salehi ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Interleukin 23

Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation

2009 ◽  
Vol 15 (6) ◽  
pp. 629-633 ◽  
Author(s):  
Emilio Fábrega ◽  
Marcos López-Hoyos ◽  
David San Segundo ◽  
Fernando Casafont ◽  
Fernando Pons-Romero
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Interleukin 23

scholarly journals Overexpression of Interleukin-23 and Interleukin-17 in the Lesion of Pemphigus Vulgaris: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Jixin Xue ◽  
Wenting Su ◽  
Zhiwei Chen ◽  
Youhui Ke ◽  
Xiaojing Du ◽  
...  
Keyword(s):  
Potential Role ◽  
Pemphigus Vulgaris ◽  
Pemphigus Foliaceus ◽  
Interleukin 17 ◽  
Healthy Individuals ◽  
Pathogenetic Role ◽  
Biopsy Specimens ◽  
Preliminary Study ◽  
Interleukin 23

IL-23/IL-17 axis has been identified as major factor involved in the pathogenesis of several autoimmune diseases; yet its pathogenetic role in pemphigus vulgaris (PV) remains controversial. The aim of this research was to investigate the potential role of IL-23/IL-17 axis in the immunopathogenesis of PV, and correlation between IL-23+ cells and IL-17+ cells was also evaluated. For this purpose, ten patients with PV, three patients with pemphigus foliaceus (PF), and six healthy individuals were allocated to this research. The lesional skin biopsy specimens were obtained before treatment. Then immunofluorescence staining was performed to analyze the expression of IL-23 and IL-17 in the PV/PF patients and the healthy individuals. The results showed that the numbers of IL-23+ and IL-17+ cells were significantly higher in PV lesions, compared to PF lesions and normal control skins, respectively (allP<0.05). Moreover, the correlation between IL-23+ cells and IL-17+ cells was significant (r=0.7546;P<0.05). Taken together, our results provided evidence that the IL-23/IL-17 axis may play a crucial role in the immunopathogenesis of PV and may serve as novel therapeutic target for PV.

Interleukin-23/ Interleukin -17 Axis in Chronic Spontaneous Urticaria: A Case- Control Study

2021 ◽  
Vol 30 (1) ◽  
pp. 169-174
Author(s):  
Lobna A. El-Korashi ◽  
Basma M. Elkholy ◽  
Hanaa M. El Maghraby
Keyword(s):  
Disease Severity ◽  
Serum Levels ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Control Group ◽  
Interleukin 17 ◽  
Autologous Serum Skin Test ◽  
Interleukin 23 ◽  
Urticaria Activity Score ◽  
Control Study

Background: Chronic Spontaneous Urticaria (CSU) is a common health problem and its clear etiology is not established yet. Several theories have been tried to illustrate its etiology and pathogenesis. Autoantibodies and inflammatory cytokines like IL-23 and IL17 are hypothesized to take part in CSU pathogenesis and outcome. Objectives: To detect serum levels of IL-23 and IL-17A among CSU patients and to determine its correlation with disease severity and its relation to autoreactivity. Methodology: Serum levels of IL-23 and IL-17A were measured in 23 patients with CSU (CSU group) and 23 healthy controls (control group). In CSU group, Weekly Urticaria Activity Score (UAS7) was recorded to assess disease severity. Autologous Serum Skin Test (ASST) was performed to assess autoreactivity. CSU patients᾿ group was subdivided, based on ASST, into positive ASST (ASST+ ) and negative ASST (ASST- ) subgroups. Correlation of serum IL-23 & IL-17A levels, with UAS7 and ASST response were analyzed. Results: CSU group had higher serum IL-17A and IL-23 levels than control group (P=0.000). ASST+ CSU had higher serum IL-17A and IL-23 levels than ASSTones (P=0.000). Additionally, UAS7 was higher in ASST+ subgroup than ASST- subgroup (32+11.7 versus 16.27+ 9.92; P =0.005). There was significant positive correlation between disease severity and serum levels of both IL-17A and IL-23 among CSU patients (r= 0.626 & P= 0.001 and r=0.515 & P= .012, respectively). Conclusion: Increased serum IL-17A and IL-23 levels may constitute two major determinants of CSU pathogenesis and severity.

scholarly journals Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Tarek Mahmoud Elghandour ◽  
Sahar El Sayed Youssef ◽  
Dalia Gamal Aly ◽  
Mohamed Said Abd Elhameed ◽  
Mehrevan Mostafa Abdel Moneim
Keyword(s):  
Narrow Band ◽  
Serum Levels ◽  
Severe Psoriasis ◽  
Ultraviolet B ◽  
Interleukin 17 ◽  
Egyptian Patients ◽  
Interleukin 23

scholarly journals Proteomic characterisations of ulcerative colitis endoscopic biopsies associate with clinically relevant histological measurements of disease severity

2021 ◽  
pp. jclinpath-2021-207718
Author(s):  
Aaron M Gruver ◽  
Matt D Westfall ◽  
Bradley L Ackermann ◽  
Salisha Hill ◽  
Ryan D Morrison ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Accuracy Assessment ◽  
Interleukin 2 ◽  
Proteome Analysis ◽  
Scoring Systems ◽  
Cell Junction ◽  
Interleukin 17 ◽  
Gamma Chain ◽  
Novel Approach ◽  
Interleukin 23

Aims and methodsAccurate protein measurements using formalin-fixed biopsies are needed to improve disease characterisation. This feasibility study used targeted and global mass spectrometry (MS) to interrogate a spectrum of disease severities using 19 ulcerative colitis (UC) biopsies.ResultsTargeted assays for CD8, CD19, CD132 (interleukin-2 receptor subunit gamma/common cytokine receptor gamma chain), FOXP3 (forkhead box P3) and IL17RA (interleukin 17 receptor A) were successful; however, assays for IL17A (interleukin 17A), IL23 (p19) (interleukin 23, alpha subunit p19) and IL23R (interleukin 23 receptor) did not permit target detection. Global proteome analysis (4200 total proteins) was performed to identify pathways associated with UC progression. Positive correlation was observed between histological scores indicating active colitis and neutrophil-related measurements (R2=0.42–0.72); inverse relationships were detected with cell junction targets (R2=0.49–0.71) and β-catenin (R2=0.51–0.55) attributed to crypt disruption. An exploratory accuracy assessment with Geboes Score and Robarts Histopathology Index cut-offs produced sensitivities/specificities of 72.7%/75.0% and 100.0%/81.8%, respectively.ConclusionsPathologist-guided MS assessments provide a complementary approach to histological scoring systems. Additional studies are indicated to verify the utility of this novel approach.

Increased Interleukin-17 and decreased BAFF serum levels in drug-free acute schizophrenia

2015 ◽  
Vol 225 (1-2) ◽  
pp. 58-63 ◽  
Author(s):  
Yousri El Kissi ◽  
Samar Samoud ◽  
Ahlem Mtiraoui ◽  
Leila Letaief ◽  
Neila Hannachi ◽  
...  
Keyword(s):  
Serum Levels ◽  
Interleukin 17 ◽  
Acute Schizophrenia ◽  
Drug Free

The influence of systemic therapy on the serum levels of IL-6 and IL-8 in pemphigus vulgaris

2011 ◽  
Vol 27 (3) ◽  
pp. 387-390 ◽  
Author(s):  
H. Mortazavi ◽  
F. Babaeijandaghi ◽  
M. Akbarzadeh ◽  
N. Rezaei ◽  
A.A. Amirzargar ◽  
...  
Keyword(s):  
Systemic Therapy ◽  
Pemphigus Vulgaris ◽  
Serum Levels

Abstract P354: Circulating Interleukin 17 A In Patients With Acute And Chronic Coronary Syndrome

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Dinaldo C Oliveira ◽  
Edivaldo Mendes Filho ◽  
Mariana Barros ◽  
Carolina Oliveira ◽  
Joao Vitor Cabral ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Volunteers ◽  
Clinical Characteristics ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Interleukin 17 ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Artery Disease

Introduction: Interleukin L-17 is produced by Th 17 cells and other cells. There is a debate if IL 17 is atherogenic or atheroprotective. The true role of this interleukin during the development and progression of the coronary artery disease is not known. Objective: To evaluate if there are differences between the IL17 A serum levels according to clinical presentation of the coronary artery disease. Methods: This is a cross sectional study which enrolled 101 patients with acute coronary syndrome (ACS), 100 patients with chronic coronary syndrome (CCS) and 100 healthy volunteers. Blood samples were taken from patients ( at admission) and controls to analysis the level of IL17A. Clinical characteristics were collected through questionnaires. This research was approved by ethical committee. Results: Comparisons of the clinical characteristics between patients with ACS and CCS revealed: mean age ( 62 ± 12.4 vs 63.3 ± 9.8, p = 0.4 ), male (63.4% vs 58%, p = 0.4) hypertension (85.1% vs 79%, p = 0.1) , disyipidemia (48% vs 31%, p =0.01), Diabetes Mellitus (47.5% vs 41%, p = 0.3), previous myocardial infarction (57.4% vs 40%, p = 0,01), smoking (29.7% vs 38%, p = 1). The peripheral concentrations of IL17A according to ACS, CCS and controls were: 5.36 ± 8.83 vs 6.69 ± 17.92 vs 6.26 ± 11.13, p = 0.6. Besides, the comparison between ACS and CCS showed: 5.36 ± 8.83 vs 6.69 ± 17.92, p = 0.3. Conclusion: The main finding os this study was that the circulating IL 17 concentrations were similar in patients with ACS, CCS and healthy volunteers). Besides, there was no difference between patients with ACS and CCS. Therefore, our hypothesis is that in patients with ACS and CCS the circulating IL 17 A concentrations are low or undetectable.

The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis

2014 ◽  
Vol 26 (4) ◽  
pp. 361-370 ◽  
Author(s):  
Nataliya Yeremenko ◽  
Jacqueline E. Paramarta ◽  
Dominique Baeten
Keyword(s):  
Interleukin 17 ◽  
Interleukin 23
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