Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation

2009 ◽  
Vol 15 (6) ◽  
pp. 629-633 ◽  
Author(s):  
Emilio Fábrega ◽  
Marcos López-Hoyos ◽  
David San Segundo ◽  
Fernando Casafont ◽  
Fernando Pons-Romero
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Interleukin 23

Decreased serum levels of interleukin‐17, interleukin‐23, TGF ‐β in pemphigus vulgaris patients, and their association with disease phase

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Zeinab Gholibeigian ◽  
Maryam Izad ◽  
Maryam Daneshpazhooh ◽  
Hossein Mortazavi ◽  
Zahra Salehi ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Interleukin 23

Serum Levels of Interleukin-34 During Acute Rejection in Liver Transplantation

2016 ◽  
Vol 48 (9) ◽  
pp. 2977-2979 ◽  
Author(s):  
D. San Segundo ◽  
P. Ruiz ◽  
J. Irure ◽  
M.T. Arias-Loste ◽  
A. Cuadrado ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Serum Levels

scholarly journals Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Cristina Macía ◽  
Jose Loureiro ◽  
Isabel Campos-Varela ◽  
Ihab Abdulkader ◽  
Esteban Otero ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Time Course ◽  
Specific Antigen ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Serum Concentrations ◽  
Caspase Cleavage ◽  
Course Changes ◽  
Keratin 18

Objective. Under normal conditions, adult hepatocytes express only keratin-8 (K8) and keratin-18 (K18), whereas cholangiocytes also express K19. In this study, we delineate the pattern of normal time-course changes in serum K19 and K18 levels after liver transplantation. Patients and Methods. Serum levels of the K19 fragment CYFRA 21-1 and the K18 fragments tissue polypeptide specific antigen (TPS) and M30 (a neoepitope that is generated after caspase cleavage during apoptosis) were measured at baseline and at regular intervals (up to 6 months) after liver transplantation in 11 adult patients. Results. There was a gradual decrease in serum K19 concentrations from baseline values after transplantation, following a time-course pattern similar to that of serum bilirubin. In contrast, serum concentrations of K18 fragments increased markedly shortly after transplantation and gradually decreased thereafter, following a time-course pattern similar to that of serum transaminases. The increase in TPS tended to occur earlier than that in M30, suggesting an initial predominance of hepatocyte necrosis followed by a predominance of apoptosis in the first days after transplantation. Five patients presented posttransplant complications (acute rejection in three cases and HCV recurrence in two cases). An early increase in serum K19 concentrations was observed in all cases. An increase in serum concentrations of K18 fragments (M30 and TPS) was observed in the two cases with HCV recurrence and was more variable in the three cases with acute rejection. Conclusions. Serum concentrations of K19 and K18 fragments follow a dissimilar pattern of time-course changes after liver transplantation. The diagnostic value of variations in these normal patterns should be addressed in future studies.

Serum Levels of Interleukin-9 During Acute Rejection in Liver Transplantation

2012 ◽  
Vol 44 (6) ◽  
pp. 1533-1535 ◽  
Author(s):  
E. Fábrega ◽  
M. López-Hoyos ◽  
D. San Segundo ◽  
F. Casafont ◽  
M. Angel Mieses ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Serum Levels ◽  
Interleukin 9

Interleukin-23/ Interleukin -17 Axis in Chronic Spontaneous Urticaria: A Case- Control Study

2021 ◽  
Vol 30 (1) ◽  
pp. 169-174
Author(s):  
Lobna A. El-Korashi ◽  
Basma M. Elkholy ◽  
Hanaa M. El Maghraby
Keyword(s):  
Disease Severity ◽  
Serum Levels ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Control Group ◽  
Interleukin 17 ◽  
Autologous Serum Skin Test ◽  
Interleukin 23 ◽  
Urticaria Activity Score ◽  
Control Study

Background: Chronic Spontaneous Urticaria (CSU) is a common health problem and its clear etiology is not established yet. Several theories have been tried to illustrate its etiology and pathogenesis. Autoantibodies and inflammatory cytokines like IL-23 and IL17 are hypothesized to take part in CSU pathogenesis and outcome. Objectives: To detect serum levels of IL-23 and IL-17A among CSU patients and to determine its correlation with disease severity and its relation to autoreactivity. Methodology: Serum levels of IL-23 and IL-17A were measured in 23 patients with CSU (CSU group) and 23 healthy controls (control group). In CSU group, Weekly Urticaria Activity Score (UAS7) was recorded to assess disease severity. Autologous Serum Skin Test (ASST) was performed to assess autoreactivity. CSU patients᾿ group was subdivided, based on ASST, into positive ASST (ASST+ ) and negative ASST (ASST- ) subgroups. Correlation of serum IL-23 & IL-17A levels, with UAS7 and ASST response were analyzed. Results: CSU group had higher serum IL-17A and IL-23 levels than control group (P=0.000). ASST+ CSU had higher serum IL-17A and IL-23 levels than ASSTones (P=0.000). Additionally, UAS7 was higher in ASST+ subgroup than ASST- subgroup (32+11.7 versus 16.27+ 9.92; P =0.005). There was significant positive correlation between disease severity and serum levels of both IL-17A and IL-23 among CSU patients (r= 0.626 & P= 0.001 and r=0.515 & P= .012, respectively). Conclusion: Increased serum IL-17A and IL-23 levels may constitute two major determinants of CSU pathogenesis and severity.

scholarly journals Effect of HO-1 modified BMMSCs on immune function of liver transplantation

2021 ◽  
Author(s):  
Peng Li ◽  
Yuyi Zhang ◽  
Qiongxia Li ◽  
Yubo Zhang
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Natural Killer ◽  
Orthotopic Liver Transplantation ◽  
Transforming Growth Factor ◽  
Nk Cell ◽  
Killer Cell ◽  
Interleukin 2 ◽  
Interleukin 17 ◽  
Protective Effects

Abstract We examined whether HO-1could enhance the immunosuppressive effects of bone marrow mesenchymal stem cell（BMMSCs）on the rejection of transplanted liver allograft in rats. The rejection model of orthotopic liver transplantation in rats was established then BMMSCs orHO-1/BMMSCs were transfused via the portal vein.The histopathological changes of the transplanted liver and the change of regulatory T cell（Tregs natural killer cell（NK）and cytokines after transplantation were observed in different groups. The severe acute rejection model rats after liver transplantation on post operation day 10 showed in NS group. BMMSCs group showed strong protective effects on rejection within the first 10 days after transplantation. While HO-1/BMMSCs showed stronger effects than BMMSCs which provided enhanced protective effects on the transplanted liver. In addition，the activity of natural killer（NK）cell decreased significantly the levels of regulatory T cells（Tregs，interleukin-10（IL-10）and transforming growth factor-β（TGF-β）increased significantly and the levels of interleukin-2（IL-2，interleukin-6（IL-6，interleukin-17（IL-17，interleukin-23（IL-23，tumor necrosis factor-α（TNF-α）and interferon-γ（IFN-γ）decreased significantly in the HO-1/BMMSCs group when compared with the BMMSCs group. Conclusions:HO-1/BMMSCs showed better immunosuppressive effects after transplantation. HO-1 could enhance the effects of BMMSCs inhibiting the immune response of acute rejection in orthotopic liver transplantation model of rats.

scholarly journals Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Tarek Mahmoud Elghandour ◽  
Sahar El Sayed Youssef ◽  
Dalia Gamal Aly ◽  
Mohamed Said Abd Elhameed ◽  
Mehrevan Mostafa Abdel Moneim
Keyword(s):  
Narrow Band ◽  
Serum Levels ◽  
Severe Psoriasis ◽  
Ultraviolet B ◽  
Interleukin 17 ◽  
Egyptian Patients ◽  
Interleukin 23
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