scholarly journals Overexpression of Interleukin-23 and Interleukin-17 in the Lesion of Pemphigus Vulgaris: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Jixin Xue ◽  
Wenting Su ◽  
Zhiwei Chen ◽  
Youhui Ke ◽  
Xiaojing Du ◽  
...  
Keyword(s):  
Potential Role ◽  
Pemphigus Vulgaris ◽  
Pemphigus Foliaceus ◽  
Interleukin 17 ◽  
Healthy Individuals ◽  
Pathogenetic Role ◽  
Biopsy Specimens ◽  
Preliminary Study ◽  
Interleukin 23

IL-23/IL-17 axis has been identified as major factor involved in the pathogenesis of several autoimmune diseases; yet its pathogenetic role in pemphigus vulgaris (PV) remains controversial. The aim of this research was to investigate the potential role of IL-23/IL-17 axis in the immunopathogenesis of PV, and correlation between IL-23+ cells and IL-17+ cells was also evaluated. For this purpose, ten patients with PV, three patients with pemphigus foliaceus (PF), and six healthy individuals were allocated to this research. The lesional skin biopsy specimens were obtained before treatment. Then immunofluorescence staining was performed to analyze the expression of IL-23 and IL-17 in the PV/PF patients and the healthy individuals. The results showed that the numbers of IL-23+ and IL-17+ cells were significantly higher in PV lesions, compared to PF lesions and normal control skins, respectively (allP<0.05). Moreover, the correlation between IL-23+ cells and IL-17+ cells was significant (r=0.7546;P<0.05). Taken together, our results provided evidence that the IL-23/IL-17 axis may play a crucial role in the immunopathogenesis of PV and may serve as novel therapeutic target for PV.

scholarly journals Antioxidant defense in centenarians (a preliminary study).

2000 ◽  
Vol 47 (2) ◽  
pp. 281-292 ◽  
Author(s):  
B Kłapcińska ◽  
J Derejczyk ◽  
K Wieczorowska-Tobis ◽  
A Sobczak ◽  
E Sadowska-Krepa ◽  
...  
Keyword(s):  
Vitamin E ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Potential Role ◽  
Serum Vitamin ◽  
Antioxidant Defenses ◽  
Human Longevity ◽  
Healthy Female ◽  
Preliminary Study

The study was designed to assess the antioxidant defense mechanisms, either enzymatic or non-enzymatic, in a group of sixteen centenarians (one male and fifteen female subjects aged 101 to 105 years) living in the Upper Silesia district (Poland) in order to evaluate the potential role of antioxidant defenses in human longevity. The results of our preliminary study showed that in comparison with young healthy female adults the centenarians had significantly higher red blood cell glutathione reductase and catalase activities and higher, although insignificantly, serum vitamin E level.

Decreased serum levels of interleukin‐17, interleukin‐23, TGF ‐β in pemphigus vulgaris patients, and their association with disease phase

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Zeinab Gholibeigian ◽  
Maryam Izad ◽  
Maryam Daneshpazhooh ◽  
Hossein Mortazavi ◽  
Zahra Salehi ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Interleukin 23

scholarly journals The Potential Role of Interleukin-17 in Severe Asthma

2011 ◽  
Vol 11 (5) ◽  
pp. 388-394 ◽  
Author(s):  
Yui-Hsi Wang ◽  
Marsha Wills-Karp
Keyword(s):  
Severe Asthma ◽  
Potential Role ◽  
Interleukin 17

Potential role of anti‐ interleukin‐17 in COVID ‐19 treatment

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Erhan Ayhan ◽  
Murat Öztürk ◽  
İsa An ◽  
Ayman Abdelmaksoud ◽  
Eşref Araç
Keyword(s):  
Potential Role ◽  
Interleukin 17

scholarly journals Role of interleukin-23/interleukin-17 axis in T-cell-mediated actions in hypertension

2020 ◽  
Author(s):  
Akinori Higaki ◽  
Ahmad U M Mahmoud ◽  
Pierre Paradis ◽  
Ernesto L Schiffrin
Keyword(s):  
Observational Studies ◽  
Current Knowledge ◽  
Interleukin 17 ◽  
Preclinical Studies ◽  
Rodent Models ◽  
Blood Pressure Elevation ◽  
Immune Mechanisms ◽  
Treatment Of Hypertension ◽  
Interleukin 23

Abstract Current knowledge suggests that hypertension is in part mediated by immune mechanisms. Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive rodent models, as well as in hypertensive humans in observational studies. Recent preclinical studies have shown that either IL-23 or IL-17A treatment induce blood pressure elevation. However, the IL-23/IL-17 axis has not been a major therapeutic target in hypertension, unlike in other autoimmune diseases. In this review, we summarize current knowledge on the role of these cytokines in immune mechanisms contributing to hypertension, and discuss the potential of IL-23/IL-17-targeted therapy for treatment of hypertension.

Excitation–contraction coupling properties in women with work-related myalgia: a preliminary study

2014 ◽  
Vol 92 (6) ◽  
pp. 498-506 ◽  
Author(s):  
Howard J. Green ◽  
Don Ranney ◽  
Margaret Burnett ◽  
Patti Galvin ◽  
Natasha Kyle ◽  
...  
Keyword(s):  
Potential Role ◽  
Healthy Controls ◽  
Β Subunit ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Work Related ◽  
Preliminary Study ◽  
Coupling Processes ◽  
Extensor Carpi Radialis

We investigated the potential role of selected excitation–contraction coupling processes in females with work-related myalgia (WRM) by comparing WRM with healthy controls (CON) using tissue from extensor carpi radialis brevis (ECRB) and trapezius (TRAP) muscles. For the ECRB, age (mean ± SE) was 29.6 ± 3.5 years for CON (n = 9) and 39.2 ± 2.8 years for WRM (n = 13), while for the TRAP, the values were 26.0 ± 2.1 years for CON (n = 7) and 44.6 ± 2.9 years for WRM (n = 11). For the sarcoplasmic reticulum (SR) of the ECRB, WRM displayed concentrations (nmol·(mg protein)−1·min−1) that were lower (P < 0.05) for Total (202 ± 4.4 vs 178 ± 7.1), Basal (34 ± 1.6 vs 30.1 ± 1.3), and maximal Ca2+-ATPase activity (Vmax, 168 ± 4.9 vs 149 ± 6.3), and Ca2+-uptake (5.06 ± 0.31 vs 4.13 ± 0.29), but not SERCA1a and SERCA2a isoforms, by comparison with CON. When age was incorporated as a co-variant, Total, Basal, and Ca2+-uptake remained different from CON (P < 0.05), but not Vmax (P = 0.13). For TRAP, none of the ATPase properties differed between groups (P > 0.05) either before or following adjustment for age. No differences (P > 0.05) were observed between the groups for Ca2+-release in the SR for either TRAP or ECRB. Similarly, no deficiencies, regardless of muscle, were noted for either the Na+–K+-ATPase content or the α and β subunit isoform distribution in WRM. This preliminary study provides a basis for further research, with expanded numbers, investigating the hypothesis that abnormalities in SR Ca2+-regulation are involved in the cellular etiology of WRM.

Potential role of interleukin-17 in the pathogenesis of bullous pemphigoid

2010 ◽  
Vol 74 (4) ◽  
pp. 727-728 ◽  
Author(s):  
Siavash Toosi ◽  
Jean-Claude Bystryn
Keyword(s):  
Bullous Pemphigoid ◽  
Potential Role ◽  
Interleukin 17
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