scholarly journals Biosimilars: a systematic review of published and ongoing clinical trials of antipsoriatics in chronic inflammatory diseases

2015 ◽  
Vol 13 (4) ◽  
pp. 294-300 ◽  
Author(s):  
Alexander Nast ◽  
Stefanie Rosumeck ◽  
Karin Seidenschnur
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

scholarly journals Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review

BioDrugs ◽  
2017 ◽  
Vol 31 (4) ◽  
pp. 299-316 ◽  
Author(s):  
Vibeke Strand ◽  
Alejandro Balsa ◽  
Jamal Al-Saleh ◽  
Leonor Barile-Fabris ◽  
Takahiko Horiuchi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

scholarly journals Biosimilars for the Treatment of Chronic Inflammatory Diseases: A Systematic Review of Published Evidence

BioDrugs ◽  
2016 ◽  
Vol 30 (6) ◽  
pp. 525-570 ◽  
Author(s):  
Ira Jacobs ◽  
Danielle Petersel ◽  
Leah Isakov ◽  
Sadiq Lula ◽  
K. Lea Sewell
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Published Evidence

scholarly journals Allium sativum L. (Garlic) Role in Osteoarthritis: A Systematic Review of Clinical Trials

2021 ◽  
Vol 11 (4) ◽  
pp. 12104-12119
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Side Effects ◽  
Allium Sativum ◽  
Inflammatory Diseases ◽  
Control Group ◽  
Therapeutic Effects ◽  
Inflammatory Factor ◽  
Anti Inflammatory ◽  
Over Time

Osteoarthritis is a chronic degenerative disease involving the joints and bones, causing their degradation over time. Inflammation, pain, and stiffness in joints are indicators of the disease. Pharmacotherapy cannot always be efficient and may cause side effects. So, adjuncts such as complementary herbs have become of note. Garlic is a herb well-known for its various therapeutic effects such as anti-bacterial, anti-hypertension, antioxidant and anti-inflammatory effects. Due to garlic's widespread use, studying its effects and mechanisms on inflammatory diseases such as osteoarthritis has been noteworthy. We searched Science Direct, Pubmed, Cochrane, and Google Scholar databases for all articles published until October 2020, based on PRISMA. Searched keywords were the following: [(garlic and arthritis), (garlic and osteoarthritis), (Garlic and OA), (Allium sativum and arthritis), (Allium sativum and osteoarthritis), (Allium sativum and OA)]. The results showed garlic, and its constituents have remarkable effects on improving OA symptoms through antioxidant and anti-inflammatory pathways. Our review shows that groups receiving garlic as a treatment showed a significant reduction in pain and inflammatory factor levels and an improved physical function instead of the control group.

scholarly journals Ozone in Medicine. The Low-Dose Ozone Concept and Its Basic Biochemical Mechanisms of Action in Chronic Inflammatory Diseases

2021 ◽  
Vol 22 (15) ◽  
pp. 7890
Author(s):  
Renate Viebahn-Haensler ◽  
Olga Sonia León Fernández
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Low Dose ◽  
Inflammatory Diseases ◽  
Clinical Status ◽  
Limiting Factor ◽  
Chronic Inflammatory Diseases ◽  
Systemic Treatments ◽  
Medical Ozone ◽  
Set Up

Low-dose ozone acts as a bioregulator in chronic inflammatory diseases, biochemically characterized by high oxidative stress and a blocked regulation. During systemic applications, “Ozone peroxides” are able to replace H2O2 in its specific function of regulation, restore redox signaling, and improve the antioxidant capacity. Two different mechanisms have to be understood. Firstly, there is the direct mechanism, used in topical treatments, mostly via radical reactions. In systemic treatments, the indirect, ionic mechanism is to be discussed: “ozone peroxide” will be directly reduced by the glutathione system, informing the nuclear factors to start the regulation. The GSH/GSSG balance outlines the ozone dose and concentration limiting factor. Antioxidants are regulated, and in the case of inflammatory diseases up-regulated; cytokines are modulated, here downregulated. Rheumatoid arthritis RA as a model for chronic inflammation: RA, in preclinical and clinical trials, reflects the pharmacology of ozone in a typical manner: SOD (superoxide dismutase), CAT (catalase) and finally GSH (reduced glutathione) increase, followed by a significant reduction of oxidative stress. Inflammatory cytokines are downregulated. Accordingly, the clinical status improves. The pharmacological background investigated in a remarkable number of cell experiments, preclinical and clinical trials is well documented and published in internationally peer reviewed journals. This should encourage clinicians to set up clinical trials with chronic inflammatory diseases integrating medical ozone as a complement.

Body composition in children with chronic inflammatory diseases: A systematic review

2020 ◽  
Vol 39 (9) ◽  
pp. 2647-2662 ◽  
Author(s):  
Noora Houttu ◽  
Marko Kalliomäki ◽  
Minna-Maija Grönlund ◽  
Harri Niinikoski ◽  
Merja Nermes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Composition ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

Chronic Inflammatory Diseases and Cardiovascular Risk: A Systematic Review

2011 ◽  
Vol 27 (2) ◽  
pp. 174-182 ◽  
Author(s):  
Idan Roifman ◽  
Paul L. Beck ◽  
Todd J. Anderson ◽  
Mark J. Eisenberg ◽  
Jacques Genest
Keyword(s):  
Systematic Review ◽  
Cardiovascular Risk ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

scholarly journals The Effect of Dietary Interventions on Chronic Inflammatory Diseases in Relation to the Microbiome: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3208
Author(s):  
Carlijn A. Wagenaar ◽  
Marieke van de van de Put ◽  
Michelle Bisschops ◽  
Wendy Walrabenstein ◽  
Catharina S. de de Jonge ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gut Microbiome ◽  
Pathogenic Bacteria ◽  
Dietary Intervention ◽  
Inflammatory Diseases ◽  
Fiber Intake ◽  
Diet Change ◽  
Dietary Interventions ◽  
Chronic Inflammatory Diseases ◽  
High Fiber

Chronic inflammation plays a central role in the pathophysiology of various non-communicable diseases. Dietary interventions can reduce inflammation, in part due to their effect on the gut microbiome. This systematic review aims to determine the effect of dietary interventions, specifically fiber intake, on chronic inflammatory diseases and the microbiome. It aims to form hypotheses on the potential mediating effects of the microbiome on disease outcomes after dietary changes. Included were clinical trials which performed a dietary intervention with a whole diet change or fiber supplement (>5 g/day) and investigated the gut microbiome in patients diagnosed with chronic inflammatory diseases such as cardiovascular disease (CVD), type 2 diabetes (T2DM), and autoimmune diseases (e.g., rheumatoid arthritis (RA), inflammatory bowel disease (IBD)). The 30 articles which met the inclusion criteria had an overall moderate to high risk of bias and were too heterogeneous to perform a meta-analysis. Dietary interventions were stratified based on fiber intake: low fiber, high fiber, and supplemental fiber. Overall, but most pronounced in patients with T2DM, high-fiber plant-based dietary interventions were consistently more effective at reducing disease-specific outcomes and pathogenic bacteria, as well as increasing microbiome alpha diversity and short-chain fatty acid (SCFA)-producing bacteria, compared to other diets and fiber supplements.

Abstract #273: Benefits of Extended Release Metformin: Systematic Review of the Ongoing Clinical Trials

2016 ◽  
Vol 22 ◽  
pp. 69
Author(s):  
Hemant Thacker ◽  
Rajeev Chawla ◽  
Navneet Agrawal ◽  
Rohit Kapoor ◽  
Noel Somasundaram ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Extended Release

L-arginine effect on inflammatory mediators: A systematic review of randomized controlled clinical trials

2019 ◽  
pp. 1-9 ◽  
Author(s):  
Seyed Reza Mirhafez ◽  
Mitra Hariri
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Inflammatory Mediators ◽  
Randomized Clinical Trials ◽  
Randomized Controlled Clinical Trials ◽  
Patients With Cancer ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
Human Adults ◽  
Factor Α

Abstract. L-arginine is an important factor in several physiological and biochemical processes. Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). We conducted a systematic review on randomized controlled trials assessing L-arginine effect on inflammatory mediators. We searched data bases including Google scholar, ISI web of science, SCOPUS, and PubMed/Medline up to April 2019. Randomized clinical trials assessing the effect of L-arginine on inflammatory mediators in human adults were included. Our search retrieved eleven articles with 387 participants. Five articles were on patients with cancer and 6 articles were on adults without cancer. L-arginine was applied in enteral form in 5 articles and in oral form in 6 articles. Eight articles were on both genders, two articles were on women, and one article was on men. L-arginine could not reduce inflammatory mediators among patients with and without cancer except one article which indicated that taking L-arginine for 6 months decreased IL-6 among cardiopathic nondiabetic patients. Our results indicated that L-arginine might not be able to reduce selected inflammatory mediators, but for making a firm decision more studies are needed to be conducted with longer intervention duration, separately on male and female and with different doses of L-arginine.

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