The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

Ryan D. Morrison; Anna L. Blobaum; Frank W. Byers; Tammy S. Santomango; Thomas M. Bridges; Donald Stec; Katrina A. Brewer; Raymundo Sanchez-Ponce; Melany M. Corlew; Roger Rush; Andrew S. Felts; Jason Manka; Brittney S. Bates; Daryl F. Venable; Alice L. Rodriguez; Carrie K. Jones; Colleen M. Niswender; P. Jeffrey Conn; Craig W. Lindsley; Kyle A. Emmitte; J. Scott Daniels

doi:10.1124/dmd.112.046136

The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

Drug Metabolism and Disposition ◽

10.1124/dmd.112.046136 ◽

2012 ◽

Vol 40 (9) ◽

pp. 1834-1845 ◽

Cited By ~ 30

Author(s):

Ryan D. Morrison ◽

Anna L. Blobaum ◽

Frank W. Byers ◽

Tammy S. Santomango ◽

Thomas M. Bridges ◽

...

Keyword(s):

Xanthine Oxidase ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Aldehyde Oxidase ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients

Clinical and Translational Science ◽

10.1111/cts.12566 ◽

2018 ◽

Vol 11 (5) ◽

pp. 523-531

Author(s):

Valérie Cosson ◽

Franziska Schaedeli-Stark ◽

Mona Arab-Alameddine ◽

Clarisse Chavanne ◽

Elena Guerini ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Population Pharmacokinetic ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand

Neuromethods - Metabotropic Glutamate Receptor Technologies ◽

10.1007/978-1-0716-1107-4_2 ◽

2021 ◽

pp. 23-37

Author(s):

Xiaofei Zhang ◽

Zhiwei Xiao ◽

Katsushi Kumata ◽

Tomoteru Yamasaki ◽

Lee Josephson ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Pet Imaging ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Positron Emission ◽

Negative Allosteric Modulator

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Effects of a Metabotropic Glutamate Receptor Subtype 7 Negative Allosteric Modulator in the Periaqueductal Grey on Pain Responses and Rostral Ventromedial Medulla Cell Activity in Rat

Molecular Pain ◽

10.1186/1744-8069-9-44 ◽

2013 ◽

Vol 9 ◽

pp. 1744-8069-9-44 ◽

Cited By ~ 17

Author(s):

Enza Palazzo ◽

Ida Marabese ◽

Livio Luongo ◽

Serena Boccella ◽

Giulia Bellini ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Cell Activity ◽

Rostral Ventromedial Medulla ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Periaqueductal Grey ◽

Metabotropic Glutamate ◽

Ventromedial Medulla ◽

Negative Allosteric Modulator

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Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01005 ◽

2015 ◽

Vol 58 (18) ◽

pp. 7485-7500 ◽

Cited By ~ 35

Author(s):

Julie L. Engers ◽

Alice L. Rodriguez ◽

Leah C. Konkol ◽

Ryan D. Morrison ◽

Analisa D. Thompson ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Anxiolytic Activity ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator ◽

Subtype 3

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Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00410 ◽

2017 ◽

Vol 60 (12) ◽

pp. 5072-5085 ◽

Cited By ~ 15

Author(s):

Andrew S. Felts ◽

Alice L. Rodriguez ◽

Anna L. Blobaum ◽

Ryan D. Morrison ◽

Brittney S. Bates ◽

...

Keyword(s):

Glutamate Receptor ◽

Clinical Evaluation ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Molecular Pharmacology ◽

10.1124/mol.107.035170 ◽

2007 ◽

Vol 72 (2) ◽

pp. 477-484 ◽

Cited By ~ 116

Author(s):

Michael A. Benneyworth ◽

Zixiu Xiang ◽

Randy L. Smith ◽

Efrain E. Garcia ◽

P. Jeffrey Conn ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate ◽

Hallucinogenic Drug

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The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain

Neurological Research ◽

10.1080/01616412.2020.1747730 ◽

2020 ◽

Vol 42 (6) ◽

pp. 515-521 ◽

Cited By ~ 1

Author(s):

Marjan Hosseini ◽

Mohsen Parviz ◽

Alireza P. Shabanzadeh ◽

Elham Zamani ◽

Parvaneh Mohseni-Moghaddam ◽

...

Keyword(s):

Neuropathic Pain ◽

Glutamate Receptor ◽

Rat Model ◽

Metabotropic Glutamate Receptor ◽

Periaqueductal Gray ◽

Receptor Subtype ◽

Central Neuropathic Pain ◽

Metabotropic Glutamate

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Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator

Psychopharmacology ◽

10.1007/s00213-012-2804-z ◽

2012 ◽

Vol 225 (1) ◽

pp. 151-159 ◽

Cited By ~ 23

Author(s):

Lucas R. Watterson ◽

Peter R. Kufahl ◽

Natali E. Nemirovsky ◽

Kaveish Sewalia ◽

Lauren E. Hood ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Seeking Behavior ◽

Negative Allosteric Modulator ◽

Food Seeking

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Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.102046 ◽

2006 ◽

Vol 318 (1) ◽

pp. 173-185 ◽

Cited By ~ 124

Author(s):

Ruggero Galici ◽

Carrie K. Jones ◽

Kamondanai Hemstapat ◽

Yi Nong ◽

Nicholas G. Echemendia ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents

European Journal of Pharmacology ◽

10.1016/j.ejphar.2009.08.047 ◽

2010 ◽

Vol 639 (1-3) ◽

pp. 106-114 ◽

Cited By ~ 25

Author(s):

Hirohiko Hikichi ◽

Takeshi Murai ◽

Shoki Okuda ◽

Shunsuke Maehara ◽

Akio Satow ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

The Central Nervous System ◽

Negative Allosteric Modulator

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