Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

Chadi G. Abdallah; Jonas Hannestad; Graeme F. Mason; Sophie E. Holmes; Nicole DellaGioia; Gerard Sanacora; Lihong Jiang; David Matuskey; Ritvij Satodiya; Fabrizio Gasparini; Xin Lin; Jonathan Javitch; Beata Planeta; Nabeel Nabulsi; Richard E. Carson; Irina Esterlis

doi:10.1016/j.bpsc.2017.03.019

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

Biological Psychiatry Cognitive Neuroscience and Neuroimaging ◽

10.1016/j.bpsc.2017.03.019 ◽

2017 ◽

Vol 2 (5) ◽

pp. 449-456 ◽

Cited By ~ 16

Author(s):

Chadi G. Abdallah ◽

Jonas Hannestad ◽

Graeme F. Mason ◽

Sophie E. Holmes ◽

Nicole DellaGioia ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Multimodal Imaging ◽

Metabotropic Glutamate Receptor ◽

Imaging Study ◽

Major Depressive ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2015.1074175 ◽

2015 ◽

Vol 24 (9) ◽

pp. 1247-1260 ◽

Cited By ~ 25

Author(s):

Kjell Fuxe ◽

Dasiel O Borroto-Escuela

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients

Clinical and Translational Science ◽

10.1111/cts.12566 ◽

2018 ◽

Vol 11 (5) ◽

pp. 523-531

Author(s):

Valérie Cosson ◽

Franziska Schaedeli-Stark ◽

Mona Arab-Alameddine ◽

Clarisse Chavanne ◽

Elena Guerini ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Population Pharmacokinetic ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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The Effects of MPEP, a Selective Metabotropic Glutamate Receptor 5 Antagonist, on Conditioned Taste Aversion in Rats

PsycEXTRA Dataset ◽

10.1037/e413812005-369 ◽

2002 ◽

Author(s):

Todd R. Schachtman ◽

Carla Bills ◽

Rodica Ghinescu ◽

Kevin Murch ◽

Agnes Simonyi

Keyword(s):

Taste Aversion ◽

Glutamate Receptor ◽

Conditioned Taste Aversion ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Faculty Opinions recommendation of Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718499023.793498248 ◽

2014 ◽

Author(s):

Roland Seifert

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Transmembrane Domain ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Class C

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Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

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Downregulation of metabotropic glutamate receptor 5 alleviates central sensitization by activating autophagy via inhibiting mTOR pathway in a rat model of chronic migraine

Neuroscience Letters ◽

10.1016/j.neulet.2020.135552 ◽

2021 ◽

Vol 743 ◽

pp. 135552

Author(s):

Yingying Niu ◽

Xiaoxu Zeng ◽

Guangcheng Qin ◽

Dunke Zhang ◽

Jiying Zhou ◽

...

Keyword(s):

Chronic Migraine ◽

Glutamate Receptor ◽

Rat Model ◽

Central Sensitization ◽

Metabotropic Glutamate Receptor ◽

Mtor Pathway ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Neuroscience ◽

10.1016/j.neuroscience.2006.06.043 ◽

2006 ◽

Vol 142 (3) ◽

pp. 691-702 ◽

Cited By ~ 67

Author(s):

D. Balschun ◽

W. Zuschratter ◽

W. Wetzel

Keyword(s):

Spatial Memory ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes

Neuroscience ◽

10.1016/j.neuroscience.2011.12.044 ◽

2012 ◽

Vol 205 ◽

pp. 29-38 ◽

Cited By ~ 26

Author(s):

J.V. Berger ◽

A.O. Dumont ◽

M.C. Focant ◽

M. Vergouts ◽

A. Sternotte ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 3 ◽

Inflammatory Stimuli

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Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus

Neuroscience ◽

10.1016/j.neuroscience.2010.06.023 ◽

2010 ◽

Vol 169 (4) ◽

pp. 1567-1574 ◽

Cited By ~ 25

Author(s):

A.H. Iyo ◽

A.M. Feyissa ◽

A. Chandran ◽

M.C. Austin ◽

S. Regunathan ◽

...

Keyword(s):

Protein Expression ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Rat Hippocampus ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats

Neuropharmacology ◽

10.1016/j.neuropharm.2011.08.028 ◽

2011 ◽

Vol 61 (8) ◽

pp. 1399-1405 ◽

Cited By ~ 28

Author(s):

Manoranjan S. D’Souza ◽

Athina Markou

Keyword(s):

Nucleus Accumbens ◽

Ventral Tegmental Area ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Nucleus Accumbens Shell ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Reinforcing Effects ◽

Ventral Tegmental

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