scholarly journals Procognitive impact of ciproxifan (a histaminergic H 3 receptor antagonist) on contextual memory retrieval after acute stress

2019 ◽  
Vol 25 (8) ◽  
pp. 832-841
Author(s):  
Frédéric Chauveau ◽  
Elodie De Job ◽  
Betty Poly‐Thomasson ◽  
Raphaël Cavroy ◽  
Julien Thomasson ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Memory Retrieval ◽  
Acute Stress ◽  
Contextual Memory

Acute stress blocks the caffeine-induced enhancement of contextual memory retrieval in mice

2015 ◽  
Vol 761 ◽  
pp. 70-78 ◽  
Author(s):  
Chistophe Pierard ◽  
Ali Krazem ◽  
Nadia Henkous ◽  
Laurence Decorte ◽  
Daniel Béracochéa
Keyword(s):  
Memory Retrieval ◽  
Acute Stress ◽  
Contextual Memory

scholarly journals Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 405 ◽  
Author(s):  
Irene Huang ◽  
Yu-Luan Hsu ◽  
Chien-Chang Chen ◽  
Mei-Fang Chen ◽  
Zhi-Hong Wen ◽  
...  
Keyword(s):  
Memory Retrieval ◽  
Potassium Current ◽  
Memory Function ◽  
Long Term Potentiation ◽  
Autism Spectrum ◽  
Absence Epilepsy ◽  
Delayed Rectifier ◽  
Contextual Memory ◽  
Term Potentiation ◽  
Delayed Rectifier Potassium Current

Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer’s disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, excavatolide-B (Exc-B), enhances contextual memory retrieval in both wild-type and Cav3.2−/− mice via repressing the delayed rectifier potassium current, thus lowering the threshold for action potential initiation and enhancing induction of long-term potentiation (LTP). The human CACNA1H gene encodes a T-type calcium channel (Cav3.2), and its mutation is associated with schizophrenia, ASD, and AE, which are all characterized by abnormal memory function. Our previous publication demonstrated that Cav3.2−/− mice exhibit impaired contextual-associated memory retrieval, whilst their retrieval of spatial memory and auditory cued memory remain intact. The effect of Exc-B on enhancing the retrieval of context-associated memory provides a hope for novel drug development.

Phosphorylated SNAP25 in the CA1 regulates morphine-associated contextual memory retrieval via increasing GluN2B-NMDAR surface localization

2017 ◽  
Vol 23 (5) ◽  
pp. 1067-1078 ◽  
Author(s):  
Xinjuan Wang ◽  
Yan Liu ◽  
Meng Jia ◽  
Xiaowei Sun ◽  
Na Wang ◽  
...  
Keyword(s):  
Memory Retrieval ◽  
Contextual Memory ◽  
Surface Localization
Sign in / Sign up

Export Citation Format

Share Document