The serotonin transporter gene variants modulate acute stress‐induced hippocampus and dorsomedial prefrontal cortex activity during memory retrieval

PsyCh Journal ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 363-377 ◽  
Author(s):  
Shijia Li ◽  
Jun Tang ◽  
Yan Gao ◽  
Christiane M. Thiel ◽  
Oliver T. Wolf
Keyword(s):  
Prefrontal Cortex ◽  
Serotonin Transporter ◽  
Memory Retrieval ◽  
Acute Stress ◽  
Serotonin Transporter Gene ◽  
Gene Variants ◽  
Transporter Gene ◽  
Dorsomedial Prefrontal Cortex

scholarly journals Serotonin transporter gene variants and prediction of stress-induced risk for psychological distress

2011 ◽  
Vol 10 (5) ◽  
pp. 536-541 ◽  
Author(s):  
N. C. Stefanis ◽  
L. Mandelli ◽  
A. Hatzimanolis ◽  
L. Zaninotto ◽  
N. Smyrnis ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Gene Variants ◽  
Transporter Gene

Harm avoidance moderates the influence of serotonin transporter gene variants on treatment outcome in bipolar patients

2009 ◽  
Vol 119 (1-3) ◽  
pp. 205-209 ◽  
Author(s):  
Laura Mandelli ◽  
Marianna Mazza ◽  
Giovanni Martinotti ◽  
Marco Di Nicola ◽  
Daniela Tavian ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Serotonin Transporter ◽  
Harm Avoidance ◽  
Serotonin Transporter Gene ◽  
Gene Variants ◽  
Transporter Gene ◽  
Bipolar Patients

scholarly journals The association of the 5-HTTLPR polymorphism and the response to different stressors in healthy males

2021 ◽  
Author(s):  
Leandra Kuhn ◽  
Hannes Noack ◽  
Nadine Skoluda ◽  
Lisa Wagels ◽  
Ann-Kristin Röhr ◽  
...  
Keyword(s):  
Working Memory ◽  
Stress Response ◽  
Serotonin Transporter ◽  
Stress Reactivity ◽  
Acute Stress ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Subjective Stress ◽  
Stress Induction ◽  
The Impact

AbstractThe experience of stress is related to individual wellbeing and vulnerability to psychopathology. Therefore, understanding the determinants of individual differences in stress reactivity is of great concern from a clinical perspective. The functional promotor polymorphism of the serotonin transporter gene (5-HTTLPR/rs25531) is such a factor, which has been linked to the acute stress response as well as the adverse effect of life stressors. In the present study, we compared the impact of two different stress induction protocols (Maastricht Acute Stress Test and ScanSTRESS) and the respective control conditions on affective ratings, salivary cortisol levels and cognitive performance. To this end, 156 healthy young males were tested and genotyped for the 5-HTTLPR/rs25531 polymorphism. While combined physiological and psychological stress in the MAST led to a greater cortisol increase compared to control conditions as well as the psychosocial ScanSTRESS, subjective stress ratings were highest in the ScanSTRESS condition. Stress induction in general affected working memory capacity but not response inhibition. Subjective stress was also influenced by 5-HTTLPR/rs25531 genotype with the high expression group showing lower stress ratings than lower expression groups. In line with previous research, we identified the low expression variant of the serotonin transporter gene as a risk factor for increased stress reactivity. While some dimensions of the human stress response may be stressor specific, cognitive outcomes such as working memory performance are influenced by stress in general. Different pathways of stress processing and possible underlying mechanisms are discussed.

Clinical Risk Factors and Serotonin Transporter Gene Variants Associated With Antidepressant-Induced Mania

2015 ◽  
Vol 76 (02) ◽  
pp. 174-180 ◽  
Author(s):  
Mark A. Frye ◽  
Susan L. McElroy ◽  
Miguel L. Prieto ◽  
Kelly L. Harper ◽  
Denise L. Walker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Clinical Risk Factors ◽  
Gene Variants ◽  
Transporter Gene ◽  
Clinical Risk

Polymorphism of the serotonin transporter gene modulates brain and physiological responses to acute stress in Japanese men

Stress ◽  
2009 ◽  
Vol 12 (6) ◽  
pp. 533-543 ◽  
Author(s):  
Hideki Ohira ◽  
Masahiro Matsunaga ◽  
Tokiko Isowa ◽  
Michio Nomura ◽  
Naho Ichikawa ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Acute Stress ◽  
Physiological Responses ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Japanese Men

Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder

1998 ◽  
Vol 43 (12) ◽  
pp. 908-912 ◽  
Author(s):  
Thomas Sander ◽  
Helmut Harms ◽  
Peter Dufeu ◽  
Silke Kuhn ◽  
Margret Hoehe ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Gene Variants ◽  
Transporter Gene ◽  
Alcohol Dependent
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