scholarly journals A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework

Author(s):  
Shivendra Tewari ◽  
Vladimir Parpura
2017 ◽  
Vol 38 (4) ◽  
pp. 2242-2259 ◽  
Author(s):  
Benjamin R. Geib ◽  
Matthew L. Stanley ◽  
Nancy A. Dennis ◽  
Marty G. Woldorff ◽  
Roberto Cabeza

2017 ◽  
Vol 331 ◽  
pp. 233-240 ◽  
Author(s):  
Habiba Rashid ◽  
Aamra Mahboob ◽  
Touqeer Ahmed

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 405 ◽  
Author(s):  
Irene Huang ◽  
Yu-Luan Hsu ◽  
Chien-Chang Chen ◽  
Mei-Fang Chen ◽  
Zhi-Hong Wen ◽  
...  

Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer’s disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, excavatolide-B (Exc-B), enhances contextual memory retrieval in both wild-type and Cav3.2−/− mice via repressing the delayed rectifier potassium current, thus lowering the threshold for action potential initiation and enhancing induction of long-term potentiation (LTP). The human CACNA1H gene encodes a T-type calcium channel (Cav3.2), and its mutation is associated with schizophrenia, ASD, and AE, which are all characterized by abnormal memory function. Our previous publication demonstrated that Cav3.2−/− mice exhibit impaired contextual-associated memory retrieval, whilst their retrieval of spatial memory and auditory cued memory remain intact. The effect of Exc-B on enhancing the retrieval of context-associated memory provides a hope for novel drug development.


2020 ◽  
Vol 375 (1799) ◽  
pp. 20190293 ◽  
Author(s):  
Thomas Schreiner ◽  
Tobias Staudigl

The reactivation of neural activity that was present during the encoding of an event is assumed to be essential for human episodic memory retrieval and the consolidation of memories during sleep. Pioneering animal work has already established a crucial role of memory reactivation to prepare and guide behaviour. Research in humans is now delineating the neural processes involved in memory reactivation during both wakefulness and sleep as well as their functional significance. Focusing on the electrophysiological signatures of memory reactivation in humans during both memory retrieval and sleep-related consolidation, this review provides an overview of the state of the art in the field. We outline recent advances, methodological developments and open questions and specifically highlight commonalities and differences in the neuronal signatures of memory reactivation during the states of wakefulness and sleep. This article is part of the Theo Murphy meeting issue ‘Memory reactivation: replaying events past, present and future’.


2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S29-S29
Author(s):  
Amy Jimenez ◽  
Junghee Lee ◽  
Jonathan K. Wynn ◽  
William Horan ◽  
Julio Iglesias ◽  
...  

Hippocampus ◽  
2020 ◽  
Vol 30 (7) ◽  
pp. 703-714
Author(s):  
Cuihong Li ◽  
Jiongjiong Yang

2017 ◽  
Vol 23 (5) ◽  
pp. 1067-1078 ◽  
Author(s):  
Xinjuan Wang ◽  
Yan Liu ◽  
Meng Jia ◽  
Xiaowei Sun ◽  
Na Wang ◽  
...  

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