Effect of poly (lactide-co-glycolide) (PLGA)-coated beta-tricalcium phosphate on the healing of rat calvarial bone defects: a comparative study with pure-phase beta-tricalcium phosphate

2016 ◽  
Vol 27 (11) ◽  
pp. 1360-1367 ◽  
Author(s):  
Takahiro Bizenjima ◽  
Takahiro Takeuchi ◽  
Fumi Seshima ◽  
Atsushi Saito
Keyword(s):  
Comparative Study ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Beta Tricalcium Phosphate ◽  
Pure Phase

scholarly journals Bone Healing Improvements Using Hyaluronic Acid and Hydroxyapatite/Beta-Tricalcium Phosphate in Combination: An Animal Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yen-Lan Chang ◽  
Yi-June Lo ◽  
Sheng-Wei Feng ◽  
Yu-Chih Huang ◽  
Hsin-Yuan Tsai ◽  
...  
Keyword(s):  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Control Sample ◽  
Volume Density ◽  
Parietal Bone ◽  
Control Group ◽  
Calvarial Bone ◽  
Handling Characteristics ◽  
Beta Tricalcium Phosphate ◽  
Aqueous Binder

The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations.

Repairing of Osteochondral Defects in Joint Using Beta-TCP/ Carboxymethyl Chitin Composite

2005 ◽  
Vol 284-286 ◽  
pp. 791-794 ◽  
Author(s):  
Shingo Masuda ◽  
Yusuke Yoshihara ◽  
Kazuaki Muramatsu ◽  
Izumi Wakebe
Keyword(s):  
Mechanical Properties ◽  
Articular Cartilage ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Bone Defects ◽  
Promising Material ◽  
Osteochondral Defects ◽  
Repair Rate ◽  
Beta Tricalcium Phosphate

Beta-tricalcium phosphate/carboxymethyl chitin composites [TCP/CMCh] of various ratios of TCP granules and CMCh were made and their mechanical properties, handling properties and repair performance for bone defects and for osteochondral defects were investigated. Water pooling ratio of CMCh was approximately 40 times the weight itself. TCP/CMCh of a higher TCP ratio had higher stress at 50%-strain. The stress at 50%-strain of TCP/CMCh with 0, 2.5, 5.0, 7.5, 10 TCP ratios was 0.12, 0.51, 1.08, 1.46, 1.67 (MPa, n=5), respectively. The TCP/CMCh with 5.0 TCP ratios had the best total scores in handling tests. The bone repair rate of TCP/CMCh was TCP ratio 2.5< Blank= TCP ratio 7.5< TCP ratio 5.0. In the implantation test for osteochondral defects, TCP/CMCh was completely absorbed at four weeks after surgery. Regeneration of the articular cartilage was seen with TCP/CMCh and HA/CMCh but not with TCP granules, which remained eight weeks after implantation. The regenerated articular cartilage had remained 32 weeks after implantation. In conclusion, it was demonstrated that this TCP/CMCh composite was a promising material for repairing osteochondral defects.

A comparative study of polymer–bioceramic composites scaffolds for bone regeneration in critical sized rabbit calvarial bone defects

2013 ◽  
Vol 42 (10) ◽  
pp. 1181-1182
Author(s):  
J. Martin ◽  
P. Aldazabal Amas ◽  
J.A. Arruti Gonzalez ◽  
F. Esnal Leal ◽  
J. Rad Carrera ◽  
...  
Keyword(s):  
Comparative Study ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Calvarial Bone

scholarly journals Histomorphometric, Immunohistochemical, Ultrastructural Characterization of a Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite and a Bone Xenograft in Sub-Critical Size Bone Defect in Rat Calvaria

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4598
Author(s):  
Igor da Silva Brum ◽  
Lucio Frigo ◽  
Renan Lana Devita ◽  
Jorge Luís da Silva Pires ◽  
Victor Hugo Vieira de Oliveira ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Periodic Acid ◽  
Bone Defects ◽  
Cellular Mechanisms ◽  
Periodic Acid Schiff ◽  
Beta Tricalcium Phosphate ◽  
Rat Calvaria ◽  
Tnf Α ◽  
Group 2 ◽  
Living Tissues

Nowadays, we can observe a worldwide trend towards the development of synthetic biomaterials. Several studies have been conducted to better understand the cellular mechanisms involved in the processes of inflammation and bone healing related to living tissues. The aim of this study was to evaluate tissue behaviors of two different types of biomaterials: synthetic nano-hydroxyapatite/beta-tricalcium phosphate composite and bone xenograft in sub-critical bone defects in rat calvaria. Twenty-four rats underwent experimental surgery in which two 3 mm defects in each cavity were tested. Rats were divided into two groups: Group 1 used xenogen hydroxyapatite (Bio Oss™); Group 2 used synthetic nano-hydroxyapatite/beta-tricalcium phosphate (Blue Bone™). Sixty days after surgery, calvaria bone defects were filled with biomaterial, animals were euthanized, and tissues were stained with Masson’s trichrome and periodic acid–Schiff (PAS) techniques, immune-labeled with anti-TNF-α and anti-MMP-9, and electron microscopy analyses were also performed. Histomorphometric analysis indicated a greater presence of protein matrix in Group 2, in addition to higher levels of TNF-α and MMP-9. Ultrastructural analysis showed that biomaterial fibroblasts were associated with the tissue regeneration stage. Paired statistical data indicated that Blue Bone™ can improve bone formation/remodeling when compared to biomaterials of xenogenous origin.

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