scholarly journals Combination with allogenic bone reduces early absorption of .BETA.-tricalcium phosphate (.BETA.-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects

2009 ◽  
Vol 28 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Makoto HIROTA ◽  
Yoshiro MATSUI ◽  
Nobuyuki MIZUKI ◽  
Teruki KISHI ◽  
Kei WATANUKI ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Animal Study ◽  
Experimental Animal ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Mandibular Bone ◽  
Allogenic Bone ◽  
Beta Tricalcium Phosphate ◽  
Experimental Animal Study

Bone Morphogenetic Protein-2 Incorporated Beta-Tricalcium Phosphate Enhanced Bone Regeneration of Critical-Sized Bone Defects in Rats

2018 ◽  
Vol 782 ◽  
pp. 283-288 ◽  
Author(s):  
Ling Fei Wei ◽  
Gang Wu ◽  
Li Quan Deng ◽  
Yue Lian Liu
Keyword(s):  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Tricalcium Phosphate ◽  
Histopathological Examination ◽  
Bone Defects ◽  
Biological Evaluation ◽  
Bone Morphogenetic Protein 2 ◽  
Beta Tricalcium Phosphate ◽  
Morphogenetic Protein ◽  
Autologous Bone

Although preclinical and clinical studies have shown the benefits of bone morphogenetic protein-2 (BMP2) in bone regeneration, there are increasing concerns about its side effects. These are mainly due to the high dosage of BMP2 which is necessary to obtain the desired clinical results. Previously our group has developed a novel controlled-release delivery system; the biomimetic calcium phosphate coating incorporated with BMP2. It can be used at much lower concentrations of BMP2 than those used in the commercially available product and still produce similar biological effects. In this study, we made a primarily biological evaluation of BMP2 incorporated beta-tricalcium phosphate (β-TCP) for bone regeneration in critical-sized bone defects. Critical-sized calvarial defects were created in rats. They were divided into four groups as follows: (1) empty defects (control), (2) defects filled with β-TCP, (3) defects filled with BMP2 incorporated β-TCP, (4) defects filled with autologous bone. Eight weeks after the operation, the efficiency of the materials was evaluated using histology and histomorphometry. Moreover, the safety of the materials was evaluated using routine blood examination, blood biochemistry examination and histopathological examination of viscera. BMP2 incorporated β-TCP demonstrated an efficiency of bone regeneration that was comparable with autologous bone, with the highest levels of new bone formation (38.3±8.4 mm3 versus 30.1±9.9 mm3, p < 0.05). All clinical lab index of blood in these four groups were within the normal range. Moreover, no change related to the treatment was noted in the histopathological examination of viscera. The results from the present study demonstrated that BMP2 incorporated β-TCP could be a promising substitute for autologous bone used for bone regeneration. Future clinical trials and preclinical trials with large animal models are necessary to investigate the safety and efficacy of BMP2 incorporated β-TCP.

Influence of residual alveolar bone height on implant stability in the maxilla: an experimental animal study

2009 ◽  
Vol 20 (8) ◽  
pp. 751-755 ◽  
Author(s):  
Matthias Fenner ◽  
Eleftherios Vairaktaris ◽  
Philipp Stockmann ◽  
Karl Andreas Schlegel ◽  
Friedrich Wilhelm Neukam ◽  
...  
Keyword(s):  
Animal Study ◽  
Experimental Animal ◽  
Alveolar Bone ◽  
Implant Stability ◽  
Experimental Animal Study ◽  
Bone Height

scholarly journals Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study

2009 ◽  
Vol 19 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Thorsten Guehring ◽  
Andreas Nerlich ◽  
Markus Kroeber ◽  
Wiltrud Richter ◽  
Georg W. Omlor
Keyword(s):  
Animal Study ◽  
Mechanical Loading ◽  
Experimental Animal ◽  
Disc Cells ◽  
Experimental Animal Study

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

Effect of low-power gallium-aluminum-arsenium laser therapy (830 nm) in combination with bisphosphonate treatment on osteopenic bone structure: an experimental animal study

2008 ◽  
Vol 24 (3) ◽  
Author(s):  
Júlia S. Diniz ◽  
Renata Amadei Nicolau ◽  
Natália de Melo Ocarino ◽  
Fernanda do Carmo Magalhães ◽  
Renato Dornas de Oliveira Pereira ◽  
...  
Keyword(s):  
Low Power ◽  
Laser Therapy ◽  
Animal Study ◽  
Experimental Animal ◽  
Bone Structure ◽  
Bisphosphonate Treatment ◽  
Experimental Animal Study ◽  
Osteopenic Bone
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