scholarly journals Blockade of interleukin-6 receptor enhances the anti-arthritic effect of glucocorticoids without decreasing bone mineral density in mice with collagen-induced arthritis

2015 ◽  
Vol 182 (2) ◽  
pp. 154-161 ◽  
Author(s):  
M. Suzuki ◽  
H. Yoshida ◽  
M. Hashizume ◽  
K. Tanaka ◽  
Y. Matsumoto
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density ◽  
Collagen Induced Arthritis ◽  
Interleukin 6 Receptor

scholarly journals Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women

2007 ◽  
Vol 157 (5) ◽  
pp. 677-684 ◽  
Author(s):  
M Bustamante ◽  
X Nogués ◽  
L Mellibovsky ◽  
L Agueda ◽  
S Jurado ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Mass ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Receptor Gene ◽  
Soluble Form ◽  
Mineral Density ◽  
Interleukin 6 Receptor

AbstractObjectiveOsteoporosis and obesity are complex diseases with a strong genetic component. Bone mineral density (BMD) and body mass index (BMI) linkage studies identified a locus at 1q21-23, where the interleukin-6 receptor (IL6R) gene is located. The IL6R and the gp130 receptors are the mediators of IL6 action. Serum levels of IL6 and sIL6R (the soluble form of IL6R) are higher in several diseases such as osteoporosis or obesity. Variants at IL6R have been associated with BMI and obesity. However, IL6R is an as-yet-unexplored osteoporosis candidate gene.DesignIn the present study we analysed two polymorphisms in the IL6R promoter, −1435 C/T (rs3887104) and −208 G/A (rs4845617), and the Asp358Ala polymorphism (rs8192284), in relation to both BMD and BMI in a cohort of 559 postmenopausal Spanish women.ResultsThe promoter polymorphisms, −1435 C/T and −208 G/A were associated with femoral neck (FN) BMD (P=0.011 and P=0.025 respectively). The C-A and T-G promoter haplotypes were also associated with FN BMD. Additionally, the Asp358Ala variant was associated with lumbar spine BMD (P=0.038). Finally, the −208 G/A polymorphism and the C-G and C-A haplotypes were associated with BMI and obesity, where GG was the risk genotype (P=0.033 for BMI; P=0.010 for obesity).ConclusionThese data suggest that variants in the IL6R gene are not only involved in the determination of BMI but also relevant for the determination of BMD. The IL6R gene may belong to the growing list of genes known to be involved in both phenotypes.

scholarly journals Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women

2003 ◽  
Vol 48 (5) ◽  
pp. 243-248 ◽  
Author(s):  
Hye Won Chung ◽  
Jeong-Sun Seo ◽  
Sung Eun Hur ◽  
Hyung Lae Kim ◽  
Jun Yeon Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density ◽  
Menopausal Women

scholarly journals Effect of minodronic acid (ONO-5920) on bone mineral density and arthritis in adult rats with collagen-induced arthritis

2003 ◽  
Vol 48 (6) ◽  
pp. 1732-1741 ◽  
Author(s):  
Itsuro Yamane ◽  
Hiroshi Hagino ◽  
Toru Okano ◽  
Makoto Enokida ◽  
Daisuke Yamasaki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Collagen Induced Arthritis ◽  
Adult Rats ◽  
Minodronic Acid

The Human Calcium-Sensing Receptor and Interleukin-6 Genes are Associated with Bone Mineral Density in Chinese

2006 ◽  
Vol 33 (10) ◽  
pp. 870-880 ◽  
Author(s):  
Yan-Bo WANG ◽  
Jing-Jing GUO ◽  
Yong-Jun LIU ◽  
Fei-Yan DENG ◽  
De-Ke JIANG ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

scholarly journals Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenoposal Japanese women

1999 ◽  
Vol 44 (3) ◽  
pp. 148-151 ◽  
Author(s):  
Kazuhiro Tsukamoto ◽  
Hideo Yoshida ◽  
Shuichiro Watanabe ◽  
Takao Suzuki ◽  
Mariko Miyao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Japanese Women ◽  
Repeat Polymorphism ◽  
Mineral Density ◽  
Ca Repeat ◽  
Ca Repeat Polymorphism ◽  
Radial Bone

Polymorphisms of the interleukin-6 gene are associated with bone mineral density

1996 ◽  
Vol 6 (S1) ◽  
pp. 89-89 ◽  
Author(s):  
RE Murray ◽  
SFA Grant ◽  
DM Reld ◽  
SH Ralston
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density

Association of Interleukin-6 Gene Polymorphisms with Bone Mineral Density in Mexican Women

2008 ◽  
Vol 39 (6) ◽  
pp. 618-624 ◽  
Author(s):  
Jonathan J. Magaña ◽  
Rocío Gómez ◽  
Bulmaro Cisneros ◽  
Leonora Casas ◽  
Margarita Valdés-Flores
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Mexican Women ◽  
Mineral Density

scholarly journals A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density

2001 ◽  
Vol 46 (5) ◽  
pp. 267-272 ◽  
Author(s):  
N. Ota ◽  
T. Nakajima ◽  
I. Nakazawa ◽  
T. Suzuki ◽  
T. Hosoi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Promoter Region ◽  
Mineral Density
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