scholarly journals A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density

2001 ◽  
Vol 46 (5) ◽  
pp. 267-272 ◽  
Author(s):  
N. Ota ◽  
T. Nakajima ◽  
I. Nakazawa ◽  
T. Suzuki ◽  
T. Hosoi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Promoter Region ◽  
Mineral Density

scholarly journals Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women

2003 ◽  
Vol 48 (5) ◽  
pp. 243-248 ◽  
Author(s):  
Hye Won Chung ◽  
Jeong-Sun Seo ◽  
Sung Eun Hur ◽  
Hyung Lae Kim ◽  
Jun Yeon Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density ◽  
Menopausal Women

The Human Calcium-Sensing Receptor and Interleukin-6 Genes are Associated with Bone Mineral Density in Chinese

2006 ◽  
Vol 33 (10) ◽  
pp. 870-880 ◽  
Author(s):  
Yan-Bo WANG ◽  
Jing-Jing GUO ◽  
Yong-Jun LIU ◽  
Fei-Yan DENG ◽  
De-Ke JIANG ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

scholarly journals Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenoposal Japanese women

1999 ◽  
Vol 44 (3) ◽  
pp. 148-151 ◽  
Author(s):  
Kazuhiro Tsukamoto ◽  
Hideo Yoshida ◽  
Shuichiro Watanabe ◽  
Takao Suzuki ◽  
Mariko Miyao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Japanese Women ◽  
Repeat Polymorphism ◽  
Mineral Density ◽  
Ca Repeat ◽  
Ca Repeat Polymorphism ◽  
Radial Bone

Polymorphisms of the interleukin-6 gene are associated with bone mineral density

1996 ◽  
Vol 6 (S1) ◽  
pp. 89-89 ◽  
Author(s):  
RE Murray ◽  
SFA Grant ◽  
DM Reld ◽  
SH Ralston
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Mineral Density

Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene (POMC) with low bone mineral density in adult women.

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Bone Mineral Density ◽  
Single Nucleotide Polymorphisms ◽  
Bone Mineral ◽  
Promoter Region ◽  
Total Cholesterol Level ◽  
Adult Women ◽  
Nucleotide Polymorphisms ◽  
Mineral Density ◽  
Single Nucleotide ◽  
Plasma Total Cholesterol Level

Among multiple factors influencing osteoporosis,genetic variations involved in bone-mineralmetabolism can affect risks predisposing to the diseaseonset. Here, we studied single-nucleotide polymorphisms(SNPs) in the pro-opiomelanocortin (POMC)gene for possible association with bone mineral density(BMD) among 384 adult Japanese women and observedsignificant correlation between adjusted BMD and threeSNPs in the promoter region (r>0.14, p<0.01). Themost significant correlation was observed for ?2353G/A(r=?0.16, p=0.002); homozygous carriers of the major(G) allele had the highest BMD (0.405±0.054 g/cm2)while heterozygous carriers were intermediate(0.390±0.053 g/cm2) and homozygous A-allele carriershad the lowest BMDs (0.369±0.048 g/cm2). Althoughno association was detected between these SNPs andbody weight or body mass index (BMI), significantassociation was detected between the ?2313A/C genotypeand plasma total cholesterol level (r=?0.12,p=0.019). We propose that POMC is among the likelysusceptibility genes for osteoporosis and may also beinvolved in dyslipidemia.

scholarly journals A gene-to-gene interaction between aromatase and estrogen receptors influences bone mineral density

2006 ◽  
Vol 155 (1) ◽  
pp. 53-59 ◽  
Author(s):  
José A Riancho ◽  
María T Zarrabeitia ◽  
Carmen Valero ◽  
Carolina Sañudo ◽  
Verónica Mijares ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptors ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Promoter Region ◽  
Gene Interaction ◽  
Strong Linkage Disequilibrium ◽  
Mineral Density ◽  
Allelic Variants ◽  
Intron 1

Objective: The aromatization of androgenic precursors is the main source of estrogens in postmenopausal women. We tested the hypothesis that allelic variants of the genes coding for aromatase and estrogen receptors (ER) could interact to determine the estrogenic signals on the bone tissue and, consequently, bone mineral density (BMD). Design: Cross-sectional study including 331 postmenopausal women. Methods: BMD was measured by dual energy x-ray absorptiometry. A CG polymorphism of the aromatase gene as well as three polymorphisms of ERα (a TA repeat in the promoter region, a C T single nucleotide polymorphism (SNP) in intron 1 and an AG SNP in exon 8) and a CA repeat polymorphism of ERβ were studied. Results: Age, body weight and the aromatase genotype were associated with BMD. Allelic variants of ERβ and the exon 8 of ERα did not show a significant association with BMD. The polymorphisms located on the promoter and intron 1 of ERα interacted strongly with aromatase. Thus, in women TT homozygous for the ERα gene, there was a marked influence of aromatase genotypes on BMD: spine BMD was 0.724±0.027 g/cm2 in women with CC aromatase alleles and 0.926±0.032 g/cm2 in those with GG alleles (P<0.001). Hip BMD in women with CC and GG aromatase genotypes was 0.722±0.020 and 0.842±0.026 g/cm2 respectively (P=0.002). On the contrary, there were no aromatase-related differences in BMD in women with CT/CC alleles of ERα. Similarly, aromatase-related differences in BMD were found in women with short alleles at the promoter region of ERα, but not in those with long alleles. Both ERα polymorphisms were in strong linkage disequilibrium (P<0.001). Conclusion: These results suggest that the interaction between polymorphisms of genes involved in estrogen synthesis and estrogen signaling exerts an important influence on BMD in postmenopausal women, thus helping to explain, in part, its heritable component. Nevertheless, further studies are warranted to confirm this gene-to-gene interaction in other populations.

Association of Interleukin-6 Gene Polymorphisms with Bone Mineral Density in Mexican Women

2008 ◽  
Vol 39 (6) ◽  
pp. 618-624 ◽  
Author(s):  
Jonathan J. Magaña ◽  
Rocío Gómez ◽  
Bulmaro Cisneros ◽  
Leonora Casas ◽  
Margarita Valdés-Flores
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Mexican Women ◽  
Mineral Density

Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus

Bone ◽  
2000 ◽  
Vol 27 (1) ◽  
pp. 169-173 ◽  
Author(s):  
I Takacs ◽  
D.L Koller ◽  
M Peacock ◽  
J.C Christian ◽  
W.E Evans ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Interleukin 6 ◽  
Gene Locus ◽  
Association Studies ◽  
Mineral Density
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