Healing potential of aStreptomycessp. secondary metabolite, SEM-1-111, on experimental full-thickness excision cutaneous wounds in Wistar rats

2013 ◽  
Vol 38 (2) ◽  
pp. 178-184 ◽  
Author(s):  
S. Sadigh-Eteghad ◽  
A. Dehnad ◽  
J. Mahmodi ◽  
H. Hoseyni ◽  
I. Khalili ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Wistar Rats ◽  
Full Thickness ◽  
Cutaneous Wounds ◽  
Full Thickness Excision

scholarly journals Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds

2016 ◽  
Vol 2016 ◽  
pp. 1-11
Author(s):  
Yssel Mendoza Marí ◽  
Maday Fernández Mayola ◽  
Ana Aguilera Barreto ◽  
Ariana García Ojalvo ◽  
Yilian Bermúdez Alvarez ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Granulation Tissue ◽  
Wistar Rats ◽  
Healing Process ◽  
Universal Model ◽  
Hypertrophic Scars ◽  
Full Thickness ◽  
Rt Pcr ◽  
Effector Cells ◽  
Cutaneous Wounds

In addition to its cytoprotective effects, growth hormone-releasing peptide 6 (GHRP-6) proved to reduce liver fibrotic induration. CD36 as one of the GHRP-6 receptors appears abundantly represented in cutaneous wounds granulation tissue. The healing response in a scenario of CD36 agonistic stimulation had not been previously investigated. Excisional full-thickness wounds (6 mmØ) were created in the dorsum of Wistar rats and topically treated twice a day for 5 days. The universal model of rabbit’s ears hypertrophic scars was implemented and the animals were treated daily for 30 days. Treatments for both species were based on a CMC jelly composition containing GHRP-6 400 μg/mL. Wounds response characterization included closure dynamic, RT-PCR transcriptional profile, histology, and histomorphometric procedures. The rats experiment indicated that GHRP-6 pharmacodynamics involves attenuation of immunoinflammatory mediators, their effector cells, and the reduction of the expression of fibrotic cytokines. Importantly, in the hypertrophic scars rabbit’s model, GHRP-6 intervention dramatically reduced the onset of exuberant scars by activating PPARγ and reducing the expression of fibrogenic cytokines. GHRP-6 showed no effect on the reversion of consolidated lesions. This evidence supports the notion that CD36 is an active and pharmacologically approachable receptor to attenuate wound inflammation and accelerate its closure so as to improve wound esthetic.

Effect of ethanolic extract of Melia dubia leaves on full‐thickness cutaneous wounds in Wistar rats

2019 ◽  
Vol 32 (6) ◽  
Author(s):  
Ponrasu Thangavel ◽  
Pratima Pathak ◽  
Iyappan Kuttalam ◽  
Suguna Lonchin
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Full Thickness ◽  
Cutaneous Wounds ◽  
Melia Dubia

scholarly journals The use of a combined sliding skin graft and a free labial mucocutaneous graft for reconstruction of the equine upper eyelid after full-thickness excision of a melanoma

2019 ◽  
Vol 7 (3) ◽  
pp. 419-425
Author(s):  
Andrea Steinmetz ◽  
Claudia Gittel ◽  
Denny Böttcher ◽  
Liv Lapko ◽  
Julia Offhaus
Keyword(s):  
Skin Graft ◽  
Full Thickness ◽  
Upper Eyelid ◽  
Full Thickness Excision

scholarly journals Efficacy of application of Equisetum pyramidale Goldm. hydrogel for tissue restoration of induced skin lesions in Wistar rats

2020 ◽  
Vol 80 (1) ◽  
pp. 12-22 ◽  
Author(s):  
F. Carmignan ◽  
R. Matias ◽  
C. A. Carollo ◽  
D. M. Dourado ◽  
M. H. Fermiano ◽  
...  
Keyword(s):  
Wistar Rats ◽  
High Efficiency ◽  
Healing Process ◽  
Ethanolic Extract ◽  
Skin Lesions ◽  
Phytochemical Analysis ◽  
Cutaneous Wounds ◽  
Tissue Restoration ◽  
Layer Chromatography ◽  
Flavonoid Patterns

Abstract Medicinal plants, such as E. pyramidale, are alternatives against infections and assist in the healing process of wounds. We evaluated the effects of Hydrogel of E. pyramidale on the healing of cutaneous wounds in animal models by morphological, morphometric and histological analyses, and elucidated major components. The ethanolic extract of E. pyramidale shoots was submitted to phytochemical analysis. For cicatrizing activity assay, Wistar rats were used, and the groups evaluated were hydrogel containing ethanolic extract of E. pyramidale at 2% compared to control groups. The treatment periods were 3, 7 and 21 days, and macroscopic and microscopic analyses were performed. Data were submitted to Analysis of Variance (p <0.05). Phytochemistry and quantification evidenced that flavonoids are main constituents and that they were evidenced by thin layer chromatography (TLC), high efficiency (HPLC) and infrared (IR) methods. In TLC, using flavonoid patterns, we observed pinocembrin. The hydrogel containing ethanolic extract of E. pyramidale at 2% was effective in wound regression. E. pyramidale can be used for the treatment of second intention wounds, and the effective healing may be due to a high flavonoid content.

Sign in / Sign up

Export Citation Format

Share Document