scholarly journals Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false‐negative metastatic lymph nodes

2017 ◽  
Vol 108 (11) ◽  
pp. 2115-2121 ◽  
Author(s):  
Asuka Tada ◽  
Sachiko Horie ◽  
Shiro Mori ◽  
Tetsuya Kodama
Keyword(s):  
Drug Delivery ◽  
Lymph Nodes ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Delivery System ◽  
False Negative ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

scholarly journals Treatment of false‐negative metastatic lymph nodes by a lymphatic drug delivery system with 5‐fluorouracil

2019 ◽  
Vol 8 (5) ◽  
pp. 2241-2251 ◽  
Author(s):  
Honoka Fujii ◽  
Sachiko Horie ◽  
Ariunbuyan Sukhbaatar ◽  
Radhika Mishra ◽  
Maya Sakamoto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lymph Nodes ◽  
Drug Delivery System ◽  
Delivery System ◽  
False Negative ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

Study of lymphatic drug delivery system using nimustine for metastatic lymph nodes

2019 ◽  
Vol 2019.31 (0) ◽  
pp. 2G34
Author(s):  
Kosuke TADANO ◽  
Ryota ISHIBASHI ◽  
Kosuke WAMURO ◽  
Shiro MORI ◽  
Tetsuya KODAMA
Keyword(s):  
Drug Delivery ◽  
Lymph Nodes ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

Validation study of sentinel lymph node mapping using radio- and dye-guided methods in gastric cancer: 431 cases at a single institution.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 76-76
Author(s):  
M. Niihara ◽  
H. Takeuchi ◽  
S. Kamiya ◽  
T. Kaburagi ◽  
T. Oyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Gastric Cancer ◽  
Lymph Nodes ◽  
False Negative ◽  
Tumor Diameter ◽  
Remnant Gastric Cancer ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

76 Background: Some papers have reported that sentinel lymph node (SLN) concept can be applied in patients with early gastric cancer, in particular clinically T1N0M0 or T2N0M0 with a tumor diameter of 4cm or less. Little is, however, available on the SLN study with the other criteria than listed above. The aim of the present work was to investigate the accuracy of the SLN biopsy of gastric cancer with various stages and evaluate the indication for SLN navigated gastrectomy. Methods: A total of 431 consecutive patients were diagnosed with operable gastric cancer during the period April 1999 through December 2007. Reasons for inclusion were, in principle, T1N0M0 or T2N0M0 gastric cancer. However, several patients diagnosed preoperatively with T3N0M0, T2N1M0, remnant gastric cancer, multiple gastric cancers and additional treatment after endoscopic therapy were also enrolled in this study according to their request. All patients underwent a radical gastrectomy with SLN mapping with an informed consent. The SLNs were identified using both radio-guided and dye-guided method. Results: Detection rate of hot and/or blue node was 95.8% (413/431). The accuracy of metastatic status based on SLN was 97.6% (403/413). In six of 10 false-negative cases, some clinical backgrounds and problems were present; scirrhous gastric cancer, the tumor penetration of serosa, multiple lesions, remnant gastric cancer after partial resection and the technical issue of tracer injection. Nine of these 10 false-negative cases had the metastatic lymph nodes within only the sentinel basins. Specifically, in the group of clinically T1N0M0 untreated gastric cancer with a tumor diameter of 4 cm or less, there were only 3 false- negative cases. In addition, all the metastatic lymph nodes of the 3 cases located within the sentinel basins. Conclusions: Our study suggested that SLN concept for untreated early gastric cancer could be validated. The sentinel basin dissection might be used to advantage to improve curativity for gastric cancer. No significant financial relationships to disclose.

Correlation between the therapeutic effect of lymphatic drug delivery system and drug osmotic pressure

2019 ◽  
Vol 2019.32 (0) ◽  
pp. 1F35
Author(s):  
Ryoichi Fukumura ◽  
Radhika Mishra ◽  
Ariunbuyan Sukhbaatar ◽  
Shiro Mori ◽  
Tetsuya Kodama
Keyword(s):  
Drug Delivery ◽  
Osmotic Pressure ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Delivery System
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