Development of Drug Delivery System for Intrathecal Administration and Its Therapeutic Effect on Cerebral Vasospasm and Ischemia

ChemInform ◽  
2005 ◽  
Vol 36 (1) ◽  
Author(s):  
Tatsuhiro Ishida
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Cerebral Vasospasm ◽  
Delivery System ◽  
Intrathecal Administration

Correlation between the therapeutic effect of lymphatic drug delivery system and drug osmotic pressure

2019 ◽  
Vol 2019.32 (0) ◽  
pp. 1F35
Author(s):  
Ryoichi Fukumura ◽  
Radhika Mishra ◽  
Ariunbuyan Sukhbaatar ◽  
Shiro Mori ◽  
Tetsuya Kodama
Keyword(s):  
Drug Delivery ◽  
Osmotic Pressure ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Delivery System

scholarly journals A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

RSC Advances ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 10975-10979 ◽  
Author(s):  
Xiaoying Gao ◽  
Jie Cao ◽  
Yinuo Song ◽  
Xiao Shu ◽  
Jianzhao Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Delivery System ◽  
Cell Imaging ◽  
Living Cells ◽  
Specific Response ◽  
Boronic Ester ◽  
Real Time Tracking

A theranostic drug delivery system composed of tetraphenylethene (AIE-gen), benzyl-boronic ester (trigger) and doxorubicin (drug) was synthesized and its functions in cell imaging, drug delivery tracking, and therapeutic effect were evaluated.

Development of a redox/pH dual stimuli-responsive MSP@P(MAA-Cy) drug delivery system for programmed release of anticancer drugs in tumour cells

2014 ◽  
Vol 2 (32) ◽  
pp. 5187-5194 ◽  
Author(s):  
Dian Li ◽  
Yuting Zhang ◽  
Sha Jin ◽  
Jia Guo ◽  
Haifeng Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Tumour Cells ◽  
Stimuli Responsive ◽  
Programmed Release

A redox/pH dual-stimuli-responsive drug delivery system for programmed release of anticancer drugs has been developed for enhancing the therapeutic effect.

Mouse Model to Explore the Therapeutic Effect of Nano-Doxorubicin Drug Delivery System on Bladder Cancer

2021 ◽  
Vol 21 (2) ◽  
pp. 914-920
Author(s):  
Bing Liu ◽  
Xiaosong Gao ◽  
Bing Han ◽  
Guohong Chen ◽  
Shuqi Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bladder Cancer ◽  
Mouse Model ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Delivery System ◽  
Drug Carrier ◽  
Drug Loading ◽  
Bladder Cancer Cell Line ◽  
Infrared Light

To study the therapeutic effect of nano-dosin-loaded drug system in mouse bladder cancer, a luciferase-labeled mouse bladder cancer cell line and a mouse bladder cancer model were constructed. In vivo imaging monitors tumor growth and uses a combination of photothermal, immune, and chemotherapy to treat the mouse model. With doxorubicin as an antitumor drug carrier, the drug loading, in vitro drug release, cytotoxicity and behavior in cells of mesoporous nano particle-targeted drug delivery system were studied. The cells were injected into the bladder through the urethra, and the mouse bladder cancer subcutaneous model was treated with gelatin-coated single-walled carbon nanotube-encapsulated mouse granulocytes-macrophage colony-stimulating factor and doxorubicin. In the process of using, the use of near-infrared light for irradiation, thereby achieving the combined effect of photothermal, immune and chemotherapy. The experimental results show that the prepared doxorubicin prodrug delivery system can enhance the targeted therapeutic effect and reduce the toxicity and side effects of the drug. Especially for those cancer cells or tissues with overexpression of folate receptors, it has a better therapeutic effect and provides reference for the treatment of subsequent bladder cancer.

A Novel Drug Delivery System as Prophylaxis for Cerebral Vasospasm

2001 ◽  
pp. 213-215 ◽  
Author(s):  
Y. Takanashi ◽  
T. Ishida ◽  
T. Meguro ◽  
M. J. Kirchmeier ◽  
T. M. Allen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Cerebral Vasospasm ◽  
Delivery System ◽  
Novel Drug Delivery System ◽  
Novel Drug
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