scholarly journals Treatment of false‐negative metastatic lymph nodes by a lymphatic drug delivery system with 5‐fluorouracil

2019 ◽  
Vol 8 (5) ◽  
pp. 2241-2251 ◽  
Author(s):  
Honoka Fujii ◽  
Sachiko Horie ◽  
Ariunbuyan Sukhbaatar ◽  
Radhika Mishra ◽  
Maya Sakamoto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lymph Nodes ◽  
Drug Delivery System ◽  
Delivery System ◽  
False Negative ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

Study of lymphatic drug delivery system using nimustine for metastatic lymph nodes

2019 ◽  
Vol 2019.31 (0) ◽  
pp. 2G34
Author(s):  
Kosuke TADANO ◽  
Ryota ISHIBASHI ◽  
Kosuke WAMURO ◽  
Shiro MORI ◽  
Tetsuya KODAMA
Keyword(s):  
Drug Delivery ◽  
Lymph Nodes ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

Validation study of sentinel lymph node mapping using radio- and dye-guided methods in gastric cancer: 431 cases at a single institution.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 76-76
Author(s):  
M. Niihara ◽  
H. Takeuchi ◽  
S. Kamiya ◽  
T. Kaburagi ◽  
T. Oyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Gastric Cancer ◽  
Lymph Nodes ◽  
False Negative ◽  
Tumor Diameter ◽  
Remnant Gastric Cancer ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

76 Background: Some papers have reported that sentinel lymph node (SLN) concept can be applied in patients with early gastric cancer, in particular clinically T1N0M0 or T2N0M0 with a tumor diameter of 4cm or less. Little is, however, available on the SLN study with the other criteria than listed above. The aim of the present work was to investigate the accuracy of the SLN biopsy of gastric cancer with various stages and evaluate the indication for SLN navigated gastrectomy. Methods: A total of 431 consecutive patients were diagnosed with operable gastric cancer during the period April 1999 through December 2007. Reasons for inclusion were, in principle, T1N0M0 or T2N0M0 gastric cancer. However, several patients diagnosed preoperatively with T3N0M0, T2N1M0, remnant gastric cancer, multiple gastric cancers and additional treatment after endoscopic therapy were also enrolled in this study according to their request. All patients underwent a radical gastrectomy with SLN mapping with an informed consent. The SLNs were identified using both radio-guided and dye-guided method. Results: Detection rate of hot and/or blue node was 95.8% (413/431). The accuracy of metastatic status based on SLN was 97.6% (403/413). In six of 10 false-negative cases, some clinical backgrounds and problems were present; scirrhous gastric cancer, the tumor penetration of serosa, multiple lesions, remnant gastric cancer after partial resection and the technical issue of tracer injection. Nine of these 10 false-negative cases had the metastatic lymph nodes within only the sentinel basins. Specifically, in the group of clinically T1N0M0 untreated gastric cancer with a tumor diameter of 4 cm or less, there were only 3 false- negative cases. In addition, all the metastatic lymph nodes of the 3 cases located within the sentinel basins. Conclusions: Our study suggested that SLN concept for untreated early gastric cancer could be validated. The sentinel basin dissection might be used to advantage to improve curativity for gastric cancer. No significant financial relationships to disclose.

scholarly journals Intranodal pressure of a metastatic lymph node reflects the response to lymphatic drug delivery system

2020 ◽  
Vol 111 (11) ◽  
pp. 4232-4241
Author(s):  
Shigeki Kato ◽  
Kazu Takeda ◽  
Ariunbuyan Sukhbaatar ◽  
Maya Sakamoto ◽  
Shiro Mori ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lymph Node ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph

scholarly journals Histopathological and Tumor Characteristics Associated with False Negative Axillary Ultrasonography Results in Breast Cancer

2019 ◽  
Vol 21 (3) ◽  
pp. 232
Author(s):  
Merve Gursoy ◽  
Gulten Sezgin ◽  
Emine Merve Horoz ◽  
Berna Dirim Mete ◽  
Nezahat Erdogan
Keyword(s):  
Lymph Nodes ◽  
Primary Tumor ◽  
False Negative ◽  
Axillary Lymph ◽  
Tumor Characteristics ◽  
Negative Group ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Significant Difference ◽  
The Mean

Aims: As the false-negative rates of axillary ultrasonography (AUS) (21%-48%) are not optimal, the demand for axillary surgery remains even if AUS is negative. The aim of this study is to determine the histopathological and tumor characteristics associated with false-negative AUS results.Materials and methods: Patients with normal AUS were divided into two groups as true-negative and false-negative according to the histopathology results of axillary lymph nodes. Two groups were compared in terms of age, histological grade of the primary tumor, histological size of the primary tumor, histological type, lymphovascular invasion (LVI), and ultrasonography BI-RADS classification of the primary tumor. The number of metastatic lymph nodes, size of the largest metastatic lymph node and the number of micrometastatic lymph nodes were also noted in the false-negative group.Results: There were 152 patients with normal preoperative AUS in the study group. The false-negative AUS rate was 20.4%. The incidence of invasive lobular carcinoma (ILC) and the mean tumor size was significantly greater in the false-negative group. Micrometastasis was present in 3 patients (3/31, 9.6%), the mean of the largest metastatic lymph nodes was 12.5 mm, the mean total number of malignant lymph nodes was 1.9 in the false-negative group. In 25/31 (80.6%) of the patients, there were less than or equal to 2 metastatic lymph nodes. The presence of LVI was higher in the false-negative group. There was no significant difference between the groups in terms of the other parameters.Conclusion: Before stating that the axilla is normal on ultrasonography, a careful evaluation should be made in patients with a mass >2 cm in size and/ or ILC diagnosis

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