scholarly journals Combined IL‐6 and JAK/STAT inhibition therapy in COVID‐19‐related sHLH, potential game changer

2020 ◽  
Vol 190 (4) ◽  
pp. 525-528 ◽  
Author(s):  
Sophie Portsmore ◽  
Thien Ngoc Tran Nguyen ◽  
Emma Beacham ◽  
Pratap Neelakantan
Keyword(s):  
Potential Game ◽  
Game Changer

A potential game changer

2019 ◽  
pp. 160-172
Author(s):  
Daud Ahmad
Keyword(s):  
Potential Game ◽  
Game Changer

East African gas-impacts for Australian LNG

2013 ◽  
Vol 53 (2) ◽  
pp. 432
Author(s):  
Simon Tysoe ◽  
Stuart Barrymore ◽  
David Clinch
Keyword(s):  
East Africa ◽  
Potential Game ◽  
East African ◽  
Petroleum Systems ◽  
Advantages And Disadvantages ◽  
Development Scenarios ◽  
Potential Development ◽  
Poor Relation ◽  
Complex Geology ◽  
Game Changer

Until recently, East Africa, with its complex geology and seemingly limited prospects, was the poor relation of the hydrocarbon provinces of West Africa. Since 2010, however, a string of successful exploration has resulted in offshore Kenya, Tanzania, and Mozambique, culminating in significant mergers and acquisitions and farming activities. Peter Coleman of Woodside described it as a potential game changer and a significant threat to the Australian LNG market. This extended abstract provides an overview of the basins and the discoveries, concentrating on the two most promising countries: Mozambique and Tanzania. The deals to date and the proposed LNG developments are also discussed. Also discussed is the petroleum regimes in each of these jurisdictions, the deals, the underlying title systems, the absence of regulation, and the key risks for parties transacting in that sector. An overview of applicable taxation regimes is supplied. This extended abstract then considers potential development scenarios and the relative advantages and disadvantages that East Africa has compared with Australia and the degree to which East Africa presents a threat to planned Australian projects. It is self-evident that the absence of infrastructure and modern petroleum systems of regulation challenge investment decisions.

Sirisena win spells change and challenge for Sri Lanka

2015 ◽  
Keyword(s):  
Prime Minister ◽  
Policy Reform ◽  
The Political ◽  
Potential Game ◽  
Content Type ◽  
Turn On ◽  
Growth Prospects ◽  
Election Results ◽  
Game Changer

Significance Sirisena's victory is a potential game-changer: instead of entrenching the autocratic tendencies of his predecessor Mahinda Rajapaksa's administration, the election results hold out the promise of democratic consolidation under a new government with a robust mandate for constitutional and policy reform. However, the diversity of the coalition backing Sirisena and the sharing of power with newly appointed Prime Minister Ranil Wickremasinghe augur a period of volatility. Impacts If Tamil parties emerge as 'kingmakers' in April, governance of war-torn Northern and Western provinces is likely to be overhauled. Delhi, Washington and Brussels will welcome the political transition. Long-term growth prospects will turn on the precise rebalancing of budgetary allocations.

scholarly journals Monoclonal antibodies against SARS-CoV-2: potential game-changer still underused

2021 ◽  
Author(s):  
Ivan Gentile ◽  
Alberto Enrico Maraolo ◽  
Antonio Riccardo Buonomo ◽  
Mariano Nobile ◽  
Prisco Piscitelli ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
High Risk ◽  
Hospital Admission ◽  
Hospital Admissions ◽  
Severe Disease ◽  
Vaccination Campaign ◽  
Potential Game ◽  
Combining Data ◽  
Game Changer ◽  
The Ideal

AbstractEven several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still in considerable numbers in many nations. Monoclonal antibodies are the ideal complement to vaccination in high-risk subjects who have been infected by SARS-CoV-2 and are at high risk of developing severe disease. Combining data provided by clinal trials and demographics of SARS-CoV-2 infections, this analysis tries to predict the benefits of an extensive use of monoclonal antibodies to reduce hospital admissions, deaths, and costs.

scholarly journals Safety Critical Software Development Methodologies in Avionics

2020 ◽  
Vol 2020 (2) ◽  
pp. 59-71
Author(s):  
Pawel Zakrzewski ◽  
Janusz Narkiewicz ◽  
Darren Brenchley
Keyword(s):  
Software Development ◽  
Development Process ◽  
Practical Knowledge ◽  
Potential Game ◽  
Standard Size ◽  
Safety Critical ◽  
Points Of View ◽  
Software Development Methodologies ◽  
Definition Of ◽  
Game Changer

AbstractThis article summarizes avionics safety-critical software development methodologies and implications of the DO-178C standard from an Agile application perspective. We explain the safety-critical software categorization. It also outlines the main differences and advantages of different approaches to the development process, from Waterfall through the V-model to Iterative and Incremental. Agile principles are explained as well as a Scrum – which is a popular framework in the non-safety-critical software industry. The application of Agile, for safety-critical software considerations, is based on the practical knowledge of the authors, and looks at the potential solution from a DO-178C standard, size of the project, scalability, and organizational culture points of view. Definition of the Agile type of framework, consistent with the certification process and existing standards, has been highlighted as a potential game-changer for the avionics industry.

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