scholarly journals Mixed phenotype acute leukaemia with predominant myeloid blasts and a small subset of B/myeloid blasts shares the same mutation profile

2019 ◽  
Vol 188 (4) ◽  
Author(s):  
Mario Capitano ◽  
Jose‐Mario Capo‐Chichi ◽  
Mark D. Minden ◽  
Hong Chang
Keyword(s):  
Acute Leukaemia ◽  
Small Subset ◽  
Mutation Profile ◽  
Mixed Phenotype

scholarly journals Mixed‐phenotype acute leukemia with a predominant B/T and a small subset of myeloid lineage expression

eJHaem ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 402-403
Author(s):  
Maryam Pourabdollah ◽  
Entsar Eladl ◽  
Aijun Liu ◽  
Hong Chang
Keyword(s):  
Acute Leukemia ◽  
Small Subset ◽  
Myeloid Lineage ◽  
Mixed Phenotype Acute Leukemia ◽  
Mixed Phenotype

A dimorphic blast population demonstrates Philadelphia-positive mixed phenotype acute leukaemia

Pathology ◽  
2014 ◽  
Vol 46 (3) ◽  
pp. 244-246 ◽  
Author(s):  
Victoria Y. Ling ◽  
Meaghan Wall ◽  
Amanda Davis ◽  
Malgorzata Gorniak ◽  
George Grigoriadis
Keyword(s):  
Acute Leukaemia ◽  
Mixed Phenotype

scholarly journals Mixed phenotype acute leukaemia with giant inclusions

2010 ◽  
Vol 149 (1) ◽  
pp. 2-2
Author(s):  
Min Shi ◽  
Fang Cui ◽  
Bo Li ◽  
Shun-Yi Li ◽  
Hui-Jie Ma
Keyword(s):  
Acute Leukaemia ◽  
Mixed Phenotype

scholarly journals Pseudo-Chédiak-Higashi granules and Auer rods in mixed phenotype acute leukaemia, T/myeloid, not otherwise specified

2017 ◽  
Vol 180 (2) ◽  
pp. 175-175 ◽  
Author(s):  
Yu Aruga ◽  
Ayumu Arakawa ◽  
Kouji Ono ◽  
Chitose Ogawa ◽  
Hiromichi Matsushita
Keyword(s):  
Acute Leukaemia ◽  
Not Otherwise Specified ◽  
Mixed Phenotype

Auer rods in neutrophils in bone marrow and peripheral blood in mixed phenotype acute leukaemia in a child

2018 ◽  
Vol 184 (5) ◽  
pp. 708-708
Author(s):  
Samia Kabbage ◽  
Roberto Cupaiolo ◽  
Laurence Rozen ◽  
Anne Demulder
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Acute Leukaemia ◽  
Mixed Phenotype

scholarly journals PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation

2018 ◽  
Vol 2 (23) ◽  
pp. 3526-3539 ◽  
Author(s):  
Wenbin Xiao ◽  
Maheetha Bharadwaj ◽  
Max Levine ◽  
Noushin Farnoud ◽  
Friederike Pastore ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Cancer Center ◽  
Small Subset ◽  
Lineage Differentiation ◽  
Recurrent Mutations ◽  
Mixed Phenotype Acute Leukemia ◽  
Sequencing Studies ◽  
Bona Fide ◽  
B Lineage ◽  
Mixed Phenotype

Abstract The genetic aberrations that drive mixed phenotype acute leukemia (MPAL) remain largely unknown, with the exception of a small subset of MPALs harboring BCR-ABL1 and MLL translocations. We performed clinicopathologic and genetic evaluation of 52 presumptive MPAL cases at Memorial Sloan Kettering Cancer Center. Only 29 out of 52 (56%) cases were confirmed to be bona fide MPAL according to the 2016 World Heath Organization classification. We identified PHF6 and DNMT3A mutations as the most common recurrent mutations in MPAL, each occurring in 6 out of 26 (23%) cases. These mutations are mutually exclusive of each other and BCR-ABL1/MLL translocations. PHF6- and DNMT3A-mutated MPAL showed marked predilection for T-lineage differentiation (5/6 PHF6 mutated, 6/6 DNMT3A mutated). PHF6-mutated MPAL occurred in a younger patient cohort compared with DNMT3A-mutated cases (median age, 27 years vs 61 years, P < .01). All 3 MPAL cases with both T- and B-lineage differentiation harbored PHF6 mutations. MPAL with T-lineage differentiation was associated with nodal or extramedullary involvement (9/15 [60%] vs 0, P = .001) and a higher relapse incidence (78% vs 22%, P = .017) compared with those without T-lineage differentiation. Sequencing studies on flow-cytometry–sorted populations demonstrated that PHF6 mutations are present in all blast compartments regardless of lineage differentiation with high variant allele frequency, implicating PHF6 as an early mutation in MPAL pathogenesis. In conclusion, PHF6 and DNMT3A mutations are the most common somatic alterations identified in MPAL and appear to define 2 distinct subgroups of MPAL with T-lineage differentiation with inferior outcomes.

scholarly journals Blinatumomab for paediatric mixed phenotype acute leukaemia

2021 ◽  
Author(s):  
Jack Bartram ◽  
Milena Balasch‐Carulla ◽  
Shashank Bhojaraja ◽  
Stuart Adams ◽  
Danny Cheng ◽  
...  
Keyword(s):  
Acute Leukaemia ◽  
Mixed Phenotype
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