scholarly journals Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990-2011

2015 ◽  
Vol 171 (1) ◽  
pp. 116-119 ◽  
Author(s):  
Marlous van Laar ◽  
Sally E. Kinsey ◽  
Richard G. Feltbower
The Lancet ◽  
1918 ◽  
Vol 191 (4945) ◽  
pp. 803
Author(s):  
JohnC. Tull

2018 ◽  
Vol 55 ◽  
pp. 96-103 ◽  
Author(s):  
A. Bonaventure ◽  
L. Orsi ◽  
J. Rudant ◽  
S. Goujon-Bellec ◽  
G. Leverger ◽  
...  

Author(s):  
G. Math� ◽  
P. Pouillart ◽  
L. Schwarzenberg ◽  
J. L. Amiel ◽  
M. Schneider ◽  
...  

2008 ◽  
Vol 24 (9) ◽  
pp. 603-610 ◽  
Author(s):  
Y Yang ◽  
XM Jin ◽  
CH Yan ◽  
Y Tian ◽  
JY Tang ◽  
...  

The 8-hydroxy-2′-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage but might also be a risk factor for many diseases including cancer. Metal exposure may play an important role in oxidative DNA damage among children. However, few studies on urinary 8-OHdG and metals have been conducted in children with acute leukemia. In the present study, urinary Ni and 8-OHdG were examined in 116 children with acute leukaemia (94 acute lymphoid leukaemia [ALL] and 22 acute myeloid leukaemia [AML]) and 51 healthy child controls. Our result showed that urinary Ni in acute leukaemia patients (ALL: 68.40 ± 133.98, AML: 41.48 ± 76.31 ng/mg creatinine) was significantly higher than that in controls (62.47 ± 124.90 vs 17.63 ± 46.17 ng/mg creatinine, P < 0.05). Similarly, the pretherapy level of urinary 8-OHdG in patients (ALL: 11.83 ± 16.23, AML: 12.36 ± 11.36 ng/mg creatinine) was significantly elevated compared with controls (11.92 ± 15.42 vs 4.03 ± 4.70 ng/mg creatinine, P < 0.05). Moreover, urinary 8-OHdG and urinary Ni showed a weak but significant association with increased risk of childhood leukaemia. The present study suggests that Ni may be an etiologic factor for childhood acute leukaemia by oxidative DNA damage.


2004 ◽  
Vol 72 (4) ◽  
pp. 302-303 ◽  
Author(s):  
Pier Paolo Piccaluga ◽  
Michele Malagola ◽  
Michela Rondoni ◽  
Marilina Amabile ◽  
Stefania Paolini ◽  
...  

1997 ◽  
Vol 96 (3) ◽  
pp. 611-613 ◽  
Author(s):  
Kiyoshi Okamoto ◽  
Masamitsu Karasawa ◽  
Hirotaka Sakai ◽  
Hidemi Ogura ◽  
Kimio Morita ◽  
...  

Leukemia ◽  
2004 ◽  
Vol 19 (1) ◽  
pp. 135-135 ◽  
Author(s):  
P P Piccaluga ◽  
G Martinelli ◽  
M Malagola ◽  
M Rondoni ◽  
F Bonifazi ◽  
...  

1976 ◽  
Vol 34 (2) ◽  
pp. 167-178 ◽  
Author(s):  
M. E. J. Beard ◽  
Jill Durrant ◽  
D. Catovsky ◽  
E. Wiltshaw ◽  
J. L. Amess ◽  
...  

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