scholarly journals Relationship between Atopic Dermatitis, Depression and Anxiety: a two‐sample Mendelian randomization study

2021 ◽  
Author(s):  
H. Baurecht ◽  
C. Welker ◽  
S.‐E. Baumeister ◽  
S. Weidnger ◽  
C. Meisinger ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mendelian Randomization ◽  
Depression And Anxiety

Causal Association Between Atopic Dermatitis and Inflammatory Bowel Disease: A 2-Sample Bidirectional Mendelian Randomization Study

2021 ◽  
Author(s):  
Christa Meisinger ◽  
Dennis Freuer
Keyword(s):  
Inflammatory Bowel Disease ◽  
Atopic Dermatitis ◽  
Bowel Disease ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
The Other ◽  
Uk Biobank ◽  
Inflammatory Bowel ◽  
The Uk

Abstract Background Observational studies postulated an association between atopic dermatitis (AD) and inflammatory bowel disease (IBD). However, it remains unclear whether this relationship is causal. Methods To determine whether AD is causally related to IBD and vice versa, a 2-sample Mendelian randomization study was conducted. Independent genetic instruments from the largest available genome-wide association study for AD (EAGLE eczema consortium without the 23andMe study including 10,788 cases and 30,047 controls) were used to investigate the association with IBD in the UK Biobank study (7045 cases, 456,327 controls) and a second European IBD sample (12,882 cases, 21,770 controls). Results Atopic dermatitis was strongly associated with higher risk of IBD as a whole (odds ratio [OR], 1.107; 95% confidence interval [CI], 1.035; 1.183; P = .003) in the UK Biobank study. The positive association was not significant in the other IBD study (OR, 1.114; 95% CI, 0.956; 1.298), but in meta-analyses of results from the 2 studies, the strong association could be confirmed (OR, 1.11; 95% CI, 1.04; 1.18). When evaluating the causal relationship in the other direction, IBD as a whole did not show an association with AD. Subtype analyses revealed that AD was suggestively associated with ulcerative colitis (UC; OR, 1.149; 95% CI, 1.018; 1.297) but not Crohn’s disease (CD). However, there was a suggestive association between CD and AD (OR, 1.034; 95% CI, 1.004; 1.064) but not UC and AD. Conclusions This study supports a causal effect between AD and IBD—but not between IBD and AD. There seems to be considerable differences between UC and CD regarding their specific associations with AD. These findings have implications for the management of IBD and AD in clinical practice.

scholarly journals Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (5) ◽  
pp. e1002294 ◽  
Author(s):  
Despoina Manousaki ◽  
Lavinia Paternoster ◽  
Marie Standl ◽  
Miriam F. Moffatt ◽  
Martin Farrall ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Mendelian Randomization ◽  
Immunoglobulin E ◽  
Vitamin D Levels

scholarly journals Assessing depression and anxiety in the caregivers of pediatric patients with chronic skin disorders

2013 ◽  
Vol 88 (6) ◽  
pp. 894-899 ◽  
Author(s):  
Ana Paula Dornelles da Silva Manzoni ◽  
Magda Blessmann Weber ◽  
Aline Rodrigues da Silva Nagatomi ◽  
Rita Langie Pereira ◽  
Roberta Zaffari Townsend ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Emotional Disorders ◽  
Pediatric Patients ◽  
Skin Diseases ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Skin Disorders ◽  
Chronic Skin

BACKGROUND: The literature has shown that the presence of emotional disturbances in caregivers of children with skin diseases affects the course and treatment of the disease. Anxiety and depression are among the most frequently reported psychiatric diagnoses related to this fact. OBJECTIVE: To evaluate the presence of anxiety and depression in caregivers of pediatric patients with chronic skin disorders, exemplified by atopic dermatitis, psoriasis and vitiligo, and correlate them to the quality of life of the patients. METHODS: The sample consisted of 118 patients with atopic dermatitis, vitiligo and psoriasis, monitored by their main caregiver. The levels of anxiety and depression in the caregivers were assessed using the Hamilton Anxiety Scale and the Beck Depression Inventory, respectively. The Children's Dermatology Life Quality Index was applied. RESULTS: Anxiety was observed in 36% of the caregivers of the patients with atopic dermatitis, in 36% of those of children affected by psoriasis, and in 42% of those responsible for pediatric patients with vitiligo. Depression occurred in 36% of the caregivers of patients with atopic dermatitis, in 36% of those of children affected by psoriasis and in 26% of those responsible for pediatric patients with vitiligo. There was a significant correlation between poor quality of life scores in patients with vitiligo and the presence of depression and anxiety in their caregivers. CONCLUSION: Emotional disorders tend to be present among close family members of children with the chronic skin diseases studied and their prevention can help in controlling and treating these diseases.

scholarly journals Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis

2021 ◽  
Vol 22 (8) ◽  
pp. 4228
Author(s):  
Dong-Hoon Park ◽  
Joo-Wan Kim ◽  
Hi-Joon Park ◽  
Dae-Hyun Hahm
Keyword(s):  
Atopic Dermatitis ◽  
Comparative Analysis ◽  
Emotional Disorders ◽  
Treatment Options ◽  
Integration Theory ◽  
Depression And Anxiety ◽  
Response Factors ◽  
New Information ◽  
Skin Symptoms ◽  
Microbial Strains

Atopic dermatitis (AD) is a refractory and relapsing skin disease with a complex and multifactorial etiology. Various congenital malformations and environmental factors are thought to be involved in the onset of the disease. The etiology of the disease has been investigated, with respect to clinical skin symptoms and systemic immune response factors. A gut microbiome–mediated connection between emotional disorders such as depression and anxiety, and dermatologic conditions such as acne, based on the comorbidities of these two seemingly unrelated disorders, has long been hypothesized. Many aspects of this gut–brain–skin integration theory have recently been revalidated to identify treatment options for AD with the recent advances in metagenomic analysis involving powerful sequencing techniques and bioinformatics that overcome the need for isolation and cultivation of individual microbial strains from the skin or gut. Comparative analysis of microbial clusters across the gut–skin axis can provide new information regarding AD research. Herein, we provide a historical perspective on the modern investigation and clinical implications of gut–skin connections in AD in terms of the integration between the two microbial clusters.

scholarly journals Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section III: Evaluation of Atopic Dermatitis Patients for Comorbidities

2018 ◽  
Vol 22 (1_suppl) ◽  
pp. 17S-20S
Author(s):  
Chih-ho Hong ◽  
Gordon Sussman ◽  
Irina Turchin ◽  
Marni Wiseman ◽  
Melinda J. Gooderham
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Disease ◽  
Atopic Dermatitis ◽  
Depression And Anxiety ◽  
Atopic Diseases ◽  
Patient Counselling ◽  
Consensus Document ◽  
Eye Disorders ◽  
Practical Recommendations

Atopic dermatitis (AD) is often associated with other atopic diseases, including asthma, allergic rhinitis, atopy-associated eye disorders, and eosinophilic esophagitis. Depression and anxiety are also comorbidities to AD that significantly affect quality of life and should be screened for in patients with AD. Links to other comorbidities such as cardiovascular disease and malignancy are considered inconclusive, but patient counselling and screening may be appropriate in some patients. This article highlights practical recommendations for the recognition and management of atopic and nonatopic comorbidities commonly associated with AD.

scholarly journals Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yik Weng Yew ◽  
Marie Loh ◽  
Steven Tien Guan Thng ◽  
John C. Chambers
Keyword(s):  
Body Mass Index ◽  
Atopic Dermatitis ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Association Studies ◽  
Experimental Studies ◽  
Genome Wide Association Studies ◽  
Increased Risk ◽  
Unit Increase ◽  
Genetically Determined

Abstract Population studies suggest that atopic dermatitis (AD) is associated with an increased risk of obesity, however a causal relationship between these two conditions remains to be established. We therefore use Mendelian randomization (MR) to evaluate whether obesity and AD are causally interlinked. We used summary statistics extracted from genome wide association studies of Body Mass Index (BMI) and AD. MR analysis was performed in both directions to establish the direction of causality between BMI and AD. We find that genetically determined increase in adiposity is associated with increased risk of AD (odds ratio of AD 1.08 [95% CI 1.01 to 1.14; p = 0.015] per unit increase in BMI). Conversely, genetically determined increased risk of AD is not associated with a higher BMI (change in BMI attributable to AD based on genetic information: 0.00; 95% CI − 0.02 to 0.02; p = 0.862). There was no evidence for confounding of these genetic analyses by horizontal pleiotropy. Our results indicate that the association of AD with obesity is likely to reflect a causal role for adiposity in the development of AD. Our findings enhance understanding of the etiology of AD, and the basis for experimental studies to evaluate the mechanistic pathways by which adiposity promotes AD.

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