scholarly journals Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis

2021 ◽  
Vol 22 (8) ◽  
pp. 4228
Author(s):  
Dong-Hoon Park ◽  
Joo-Wan Kim ◽  
Hi-Joon Park ◽  
Dae-Hyun Hahm
Keyword(s):  
Atopic Dermatitis ◽  
Comparative Analysis ◽  
Emotional Disorders ◽  
Treatment Options ◽  
Integration Theory ◽  
Depression And Anxiety ◽  
Response Factors ◽  
New Information ◽  
Skin Symptoms ◽  
Microbial Strains

Atopic dermatitis (AD) is a refractory and relapsing skin disease with a complex and multifactorial etiology. Various congenital malformations and environmental factors are thought to be involved in the onset of the disease. The etiology of the disease has been investigated, with respect to clinical skin symptoms and systemic immune response factors. A gut microbiome–mediated connection between emotional disorders such as depression and anxiety, and dermatologic conditions such as acne, based on the comorbidities of these two seemingly unrelated disorders, has long been hypothesized. Many aspects of this gut–brain–skin integration theory have recently been revalidated to identify treatment options for AD with the recent advances in metagenomic analysis involving powerful sequencing techniques and bioinformatics that overcome the need for isolation and cultivation of individual microbial strains from the skin or gut. Comparative analysis of microbial clusters across the gut–skin axis can provide new information regarding AD research. Herein, we provide a historical perspective on the modern investigation and clinical implications of gut–skin connections in AD in terms of the integration between the two microbial clusters.

scholarly journals Assessing depression and anxiety in the caregivers of pediatric patients with chronic skin disorders

2013 ◽  
Vol 88 (6) ◽  
pp. 894-899 ◽  
Author(s):  
Ana Paula Dornelles da Silva Manzoni ◽  
Magda Blessmann Weber ◽  
Aline Rodrigues da Silva Nagatomi ◽  
Rita Langie Pereira ◽  
Roberta Zaffari Townsend ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Emotional Disorders ◽  
Pediatric Patients ◽  
Skin Diseases ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Skin Disorders ◽  
Chronic Skin

BACKGROUND: The literature has shown that the presence of emotional disturbances in caregivers of children with skin diseases affects the course and treatment of the disease. Anxiety and depression are among the most frequently reported psychiatric diagnoses related to this fact. OBJECTIVE: To evaluate the presence of anxiety and depression in caregivers of pediatric patients with chronic skin disorders, exemplified by atopic dermatitis, psoriasis and vitiligo, and correlate them to the quality of life of the patients. METHODS: The sample consisted of 118 patients with atopic dermatitis, vitiligo and psoriasis, monitored by their main caregiver. The levels of anxiety and depression in the caregivers were assessed using the Hamilton Anxiety Scale and the Beck Depression Inventory, respectively. The Children's Dermatology Life Quality Index was applied. RESULTS: Anxiety was observed in 36% of the caregivers of the patients with atopic dermatitis, in 36% of those of children affected by psoriasis, and in 42% of those responsible for pediatric patients with vitiligo. Depression occurred in 36% of the caregivers of patients with atopic dermatitis, in 36% of those of children affected by psoriasis and in 26% of those responsible for pediatric patients with vitiligo. There was a significant correlation between poor quality of life scores in patients with vitiligo and the presence of depression and anxiety in their caregivers. CONCLUSION: Emotional disorders tend to be present among close family members of children with the chronic skin diseases studied and their prevention can help in controlling and treating these diseases.

scholarly journals Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1

2021 ◽  
Vol 22 (5) ◽  
pp. 2334
Author(s):  
Jae Ho Choi ◽  
Gi Ho Lee ◽  
Sun Woo Jin ◽  
Ji Yeon Kim ◽  
Yong Pil Hwang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Histopathological Analysis ◽  
Mrna Levels ◽  
Chemokine Production ◽  
Dermal Thickness ◽  
Skin Symptoms ◽  
Tnf Α ◽  
Ifn Γ ◽  
In Cells

Impressic acid (IPA), a lupane-type triterpenoid from Acanthopanax koreanum, has many pharmacological activities, including the attenuation of vascular endothelium dysfunction, cartilage destruction, and inflammatory diseases, but its influence on atopic dermatitis (AD)-like skin lesions is unknown. Therefore, we investigated the suppressive effect of IPA on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin symptoms in mice and the underlying mechanisms in cells. IPA attenuated the DNCB-induced increase in the serum concentrations of IgE and thymic stromal lymphopoietin (TSLP), and in the mRNA levels of thymus and activation regulated chemokine(TARC), macrophage derived chemokine (MDC), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in mice. Histopathological analysis showed that IPA reduced the epidermal/dermal thickness and inflammatory and mast cell infiltration of ear tissue. In addition, IPA attenuated the phosphorylation of NF-κB and IκBα, and the degradation of IκBα in ear lesions. Furthermore, IPA treatment suppressed TNF-α/IFN-γ-induced TARC expression by inhibiting the NF-κB activation in cells. Phosphorylation of extracellular signalregulated protein kinase (ERK1/2) and the signal transducer and activator of transcription 1 (STAT1), the upstream signaling proteins, was reduced by IPA treatment in HaCaT cells. In conclusion, IPA ameliorated AD-like skin symptoms by regulating cytokine and chemokine production and so has therapeutic potential for AD-like skin lesions.

Episodic versus Chronic Dizziness: An Analysis of Predictive Factors

2021 ◽  
pp. 000348942110254
Author(s):  
Eric J. Formeister ◽  
Ricky Chae ◽  
Emily Wong ◽  
Whitney Chiao ◽  
Lauren Pasquesi ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Treatment Options ◽  
Depression And Anxiety ◽  
Imaging Studies ◽  
Comorbid Depression ◽  
Cross Sectional ◽  
Tertiary Center ◽  
Chronic Dizziness ◽  
Associated Symptoms ◽  
History Of

Objectives: To elucidate differences in demographic and clinical characteristics between patients with episodic and chronic dizziness. Methods: A cross-sectional, observational study of 217 adults referred for dizziness at 1 tertiary center was undertaken. Subjects were split into a chronic dizziness group (>15 dizzy days per month) and an episodic dizziness group (<15 dizzy days per month). Results: 217 adults (average age, 53.7 years; 56.7% female) participated. One-third (n = 74) met criteria for chronic dizziness. Dizziness handicap inventory (DHI) scores were significantly higher in those with chronic dizziness compared to those with episodic dizziness (53.9 vs 40.7; P < .001). Comorbid depression and anxiety were more prevalent in those with chronic dizziness (44.6% and 47.3% vs 37.8% and 35.7%, respectively; P > .05). Abnormal vestibular testing and abnormal imaging studies did not differ significantly between the 2 groups. Ménière’s disease and BPPV were significantly more common among those with episodic dizziness, while the prevalence of vestibular migraine did not differ according to chronicity of symptoms. A multivariate regression that included age, sex, DHI, history of anxiety and/or depression, associated symptoms, and dizziness triggers was able to account for 15% of the variance in the chronicity of dizziness (pseudo- R2 = 0.15; P < .001). Conclusions: Those who suffer from chronic dizziness have significantly higher DHI and high comorbid rates of depression and anxiety than those with episodic dizziness. Our findings show that factors other than diagnosis alone are important in the chronification of dizziness, an observation that could help improve on multimodal treatment options for this group of patients.

scholarly journals Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus

2021 ◽  
Author(s):  
Hitoshi Sakurai ◽  
Norio Yasui-Furukori ◽  
Takefumi Suzuki ◽  
Hiroyuki Uchida ◽  
Hajime Baba ◽  
...  
Keyword(s):  
Relapse Prevention ◽  
Negative Symptoms ◽  
Japanese Society ◽  
Treatment Guidelines ◽  
Treatment Options ◽  
Standard Deviation Score ◽  
Expert Consensus ◽  
Depression And Anxiety ◽  
First Line ◽  
A Current

Abstract Introduction Conventional treatment guidelines of schizophrenia do not necessarily provide solutions on clinically important issues. Methods A total of 141 certified psychiatrists of the Japanese Society of Clinical Neuropsychopharmacology evaluated treatment options regarding 19 clinically relevant situations in the treatment of schizophrenia with a 9-point scale (1=“disagree” and 9=“agree”). Results First-line antipsychotics varied depending on predominant symptoms: risperidone (mean±standard deviation score, 7.9±1.4), olanzapine (7.5±1.6), and aripiprazole (6.9±1.9) were more likely selected for positive symptoms; aripiprazole (7.6±1.6) for negative symptoms; aripiprazole (7.3±1.9), olanzapine (7.2±1.9), and quetiapine (6.9±1.9) for depression and anxiety; and olanzapine (7.9±1.5) and risperidone (7.5±1.5) for excitement and aggression. While only aripiprazole was categorized as a first-line treatment for relapse prevention (7.6±1.0) in patients without noticeable symptoms, aripiprazole (8.0±1.6) and brexpiprazole (6.9±2.3) were categorized as such for social integration. First-line treatments in patients who are vulnerable to extrapyramidal symptoms include quetiapine (7.5±2.0) and aripiprazole (6.9±2.1). Discussion These clinical recommendations represent the expert consensus on the use of a particular antipsychotic medication for a particular situation, filling a current gap in the literature.

scholarly journals Initial Effectiveness Evaluation of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders for Homeless Women

2020 ◽  
pp. 014544552098256
Author(s):  
Sara Rodriguez-Moreno ◽  
Todd J. Farchione ◽  
Pablo Roca ◽  
Carolina Marín ◽  
Ana I. Guillén ◽  
...  
Keyword(s):  
Negative Affect ◽  
Emotional Disorders ◽  
Group Treatment ◽  
Linear Trend ◽  
Control Period ◽  
Well Being ◽  
Homeless Women ◽  
Depression And Anxiety ◽  
Transdiagnostic Treatment ◽  
Unified Protocol

The purpose of this study is to evaluate the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders adapted for homeless women (UPHW). Eighty-one homeless women participated in this single-blinded quasi-experimental clinical trial, involving up to 12 sessions of group treatment, and 3-and 6-month follow-ups. The participants received either immediate treatment with the UPHW ( n = 46) or delayed treatment, following a 12-week wait-list control period (WLC; n = 35). Primary outcomes included depression and anxiety. Secondary measures comprised positive and negative affect, psychological well-being, health perception, and social support. The UPHW resulted in significant improvement on measures of anxiety, depression and negative affect. Improvements in anxiety and depression were maintained over a 3-month follow-up period, but not at 6-month. The reliability of the clinical changes showed significant differences between UPHW and WLC for depression. Moreover, the inter-session assessment in the UPHW group showed a linear trend reduction for depression and anxiety scores along the 12 sessions. The clinical implications on the UPHW in social settings are also discussed.

scholarly journals THE ADOPTION AND USE OF NEW INFORMATION AND COMMUNICATION TECHNOLOGIES AT THE LEVEL OF CEE-EU COUNTRIES

2018 ◽  
Vol 6 ◽  
pp. 69-75 ◽  
Author(s):  
Mihai Costea ◽  
Gabriela Arionesei ◽  
Cristian Valentin Hapenciuc
Keyword(s):  
Comparative Analysis ◽  
Information And Communication Technologies ◽  
Free Market ◽  
Communication Technologies ◽  
Communist Regime ◽  
International Institute ◽  
International Telecommunication Union ◽  
Eu Countries ◽  
New Information ◽  
Information And Communication

This paper focuses on determining the current state of adoption of new information and communication technologies by the population of EU countries from the Central and Eastern parts of Europe (referred in the paper as CEE-EU countries). We have conducted a detailed analysis between Romania and Bulgaria because there are historical, geographical, political and economic similarities between these two neighbouring countries. In order to objectively reflect the results of the comparative analysis at the regional level, we have used the data provided by the World Economic Forum through the Competitiveness Index, the International Institute for Management Development through the Competitiveness Yearbook and the International Telecommunication Union through the ICT Development Index. The results of the comparative analysis reflect many regional disparities. At the same time, it can be noticed that both Romania and Bulgaria are the countries with the weakest results regarding the penetration rate of Internet accessibility in their populations, a fact which leads to a low degree of adaptability of the human capital to new information technologies and, implicitly, a low rate of adoption of the Internet in the sphere of business and public services. This is explained by the insufficient development of ICT infrastructure in the rural area, caused by numerous factors such as insufficient economic development and the low purchasing power of the population, but also by the relatively low level of education in ICT use. Although the influx of information and communication technologies occurred after the 1990s, namely at a time when even countries like Romania or Bulgaria were already part of the free market economy, the gaps recorded during the communist regime (economic, but especially socio-cultural), were apparently difficult to recover in the years to come, therefore this upsurge in information technology has been somewhat delayed in the South-Eastern area of Europe.

scholarly journals Comparison of Interpersonal and Intrapersonal Emotion Regulation Models in Explaining Depression and Anxiety Syndrome

2021 ◽  
Author(s):  
Mozhgan Lotfi ◽  
◽  
Mahdi Amini ◽  
Yasaman Shiasy ◽  
◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Emotional Disorders ◽  
Depression And Anxiety ◽  
Emotion Regulation Strategies ◽  
Cross Sectional ◽  
Statistical Population ◽  
Multi Stage ◽  
Interpersonal Emotion Regulation ◽  
Regulation Strategies ◽  
Regulation Model

Background: Emotion regulation is an important meta-diagnosis construct and one of the common core and underlying dimensions of emotional disorders. Emotion regulation models are divided into two general categories of interpersonal and interpersonal models. Purpose: This study aimed to compare interpersonal and intrapersonal models of emotion regulation in predicting depression and anxiety syndromes in Tehran universities students. Method and material: The method of this study was cross-sectional. The statistical population of this study was all students of public universities in Tehran. Sampling was done using multi-stage cluster and the subjects were evaluated using Emotion Regulation Strategies Questionnaire, Interpersonal Emotion Regulation Questionnaire, Short Difficulty in Emotion Regulation Questionnaire and SCL-25 Questionnaire. Results: Findings showed that intrapersonal and interpersonal emotion regulation strategies have a significant role in explaining depression and anxiety syndrome. Between the two interpersonal and interpersonal emotion regulation models, the interpersonal emotion regulation model had a stronger and more significant effect on prediction of depression and anxiety syndrome (P <0.01). Conclusion: Both intrapersonal and interpersonal emotion regulation models have role in explanation of depression and anxiety syndromes and can be effective in predicting and treating emotional disorders.

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