Relationship Between Body Mass Index and Atopic Dermatitis: Critical Appraisal of a Mendelian Randomization Approach in Exploring Causality

2020 ◽  
Author(s):  
C.X. Pan ◽  
Y.‐H. Jee ◽  
K.J. Moore ◽  
P. Kraft ◽  
M.M. Asgari
Keyword(s):  
Body Mass Index ◽  
Atopic Dermatitis ◽  
Body Mass ◽  
Critical Appraisal ◽  
Mendelian Randomization

scholarly journals Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yik Weng Yew ◽  
Marie Loh ◽  
Steven Tien Guan Thng ◽  
John C. Chambers
Keyword(s):  
Body Mass Index ◽  
Atopic Dermatitis ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Association Studies ◽  
Experimental Studies ◽  
Genome Wide Association Studies ◽  
Increased Risk ◽  
Unit Increase ◽  
Genetically Determined

Abstract Population studies suggest that atopic dermatitis (AD) is associated with an increased risk of obesity, however a causal relationship between these two conditions remains to be established. We therefore use Mendelian randomization (MR) to evaluate whether obesity and AD are causally interlinked. We used summary statistics extracted from genome wide association studies of Body Mass Index (BMI) and AD. MR analysis was performed in both directions to establish the direction of causality between BMI and AD. We find that genetically determined increase in adiposity is associated with increased risk of AD (odds ratio of AD 1.08 [95% CI 1.01 to 1.14; p = 0.015] per unit increase in BMI). Conversely, genetically determined increased risk of AD is not associated with a higher BMI (change in BMI attributable to AD based on genetic information: 0.00; 95% CI − 0.02 to 0.02; p = 0.862). There was no evidence for confounding of these genetic analyses by horizontal pleiotropy. Our results indicate that the association of AD with obesity is likely to reflect a causal role for adiposity in the development of AD. Our findings enhance understanding of the etiology of AD, and the basis for experimental studies to evaluate the mechanistic pathways by which adiposity promotes AD.

scholarly journals Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

2018 ◽  
Vol 111 (4) ◽  
pp. 350-364 ◽  
Author(s):  
Frank Qian ◽  
Shengfeng Wang ◽  
Jonathan Mitchell ◽  
Lesley McGuffog ◽  
Daniel Barrowdale ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Mutation Carriers

scholarly journals Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis

2014 ◽  
Vol 94 (2) ◽  
pp. 312 ◽  
Author(s):  
Michael V. Holmes ◽  
Leslie A. Lange ◽  
Tom Palmer ◽  
Matthew B. Lanktree ◽  
Kari E. North ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Causal Effects ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis ◽  
Cardiometabolic Traits

scholarly journals The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

2018 ◽  
Author(s):  
Amy E. Taylor ◽  
Rebecca C. Richmond ◽  
Teemu Palviainen ◽  
Anu Loukola ◽  
Jaakko Kaprio ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
Smoking Initiation ◽  
Smoking Behaviour ◽  
Bidirectional Association ◽  
Metabolite Ratio ◽  
Nicotine Metabolite Ratio

AbstractBackgroundGiven clear evidence that smoking lowers weight, it is possible that individuals with higher body mass index (BMI) smoke in order to lose or maintain their weight.Methods and FindingsWe undertook Mendelian randomization analyses using 97 genetic variants associated with BMI. We performed two sample Mendelian randomization analyses of the effects of BMI on smoking behaviour in UK Biobank (N=335,921) and the Tobacco and Genetics consortium genomewide association study (GWAS) (N≤74,035) respectively, and two sample Mendelian randomization analyses of the effects of BMI on cotinine levels (N≤4,548) and nicotine metabolite ratio (N≤1,518) in published GWAS, and smoking-related DNA methylation in the Avon Longitudinal Study of Parents and Children (N≤846).In inverse variance weighted Mendelian randomization analysis, there was evidence that higher BMI was causally associated with smoking initiation (OR for ever vs never smoking per one SD increase in BMI: 1.19, 95% CI: 1.11 to 1.27) and smoking heaviness (1.45 additional cigarettes smoked per day per SD increase in BMI, 95% CI: 1.03 to 1.86), but little evidence for a causal effect with smoking cessation. Results were broadly similar using pleiotropy robust methods (MR-Egger, median and weighted mode regression). These results were supported by evidence for a causal effect of BMI on DNA methylation at the aryl-hydrocarbon receptor repressor (AHRR) locus. There was no strong evidence that BMI was causally associated with cotinine, but suggestive evidence for a causal negative association with the nicotine metabolite ratio.ConclusionsThere is a causal bidirectional association between BMI and smoking, but the relationship is likely to be complex due to opposing effects on behaviour and metabolism. It may be useful to consider BMI and smoking together when designing prevention strategies to minimise the effects of these risk factors on health outcomes.

Abstract P324: Body Mass Index, Walking Pace, and Risk of Coronary Heart Disease: a Mendelian Randomization and Mediation Analysis

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Tao Zhou ◽  
Dianjianyi Sun ◽  
Xiang Li ◽  
Mengyu Fan ◽  
Yoriko Heianza ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Body Mass ◽  
Mediation Analysis ◽  
Mendelian Randomization

Body mass index and serum lipid profile: Association with atopic dermatitis in a paediatric population

2019 ◽  
Vol 61 (1) ◽  
Author(s):  
Pedro Jesús Agón‐Banzo ◽  
Rosalía Sanmartin ◽  
Ana Julia García‐Malinis ◽  
Ángela Hernández‐Martín ◽  
José Puzo ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Atopic Dermatitis ◽  
Lipid Profile ◽  
Body Mass ◽  
Serum Lipid ◽  
Paediatric Population ◽  
Serum Lipid Profile

scholarly journals Application of Mendelian Randomization to Investigate the Association of Body Mass Index with Health Care Costs

2020 ◽  
Vol 40 (2) ◽  
pp. 156-169 ◽  
Author(s):  
Christoph F. Kurz ◽  
Michael Laxy
Keyword(s):  
Health Care ◽  
Body Mass Index ◽  
Body Mass ◽  
Health Care Costs ◽  
Instrumental Variables ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
Omitted Variables ◽  
Care Costs ◽  
Genetic Instruments

Causal effect estimates for the association of obesity with health care costs can be biased by reversed causation and omitted variables. In this study, we use genetic variants as instrumental variables to overcome these limitations, a method that is often called Mendelian randomization (MR). We describe the assumptions, available methods, and potential pitfalls of using genetic information and how to address them. We estimate the effect of body mass index (BMI) on total health care costs using data from a German observational study and from published large-scale data. In a meta-analysis of several MR approaches, we find that models using genetic instruments identify additional annual costs of €280 for a 1-unit increase in BMI. This is more than 3 times higher than estimates from linear regression without instrumental variables (€75). We found little evidence of a nonlinear relationship between BMI and health care costs. Our results suggest that the use of genetic instruments can be a powerful tool for estimating causal effects in health economic evaluation that might be superior to other types of instruments where there is a strong association with a modifiable risk factor.

scholarly journals Assessment of a causal relationship between body mass index and atopic dermatitis

2021 ◽  
Vol 147 (1) ◽  
pp. 400-403 ◽  
Author(s):  
Ashley Budu-Aggrey ◽  
Sarah H. Watkins ◽  
Ben Brumpton ◽  
Mari Løset ◽  
Jess Tyrrell ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Atopic Dermatitis ◽  
Causal Relationship ◽  
Body Mass
Sign in / Sign up

Export Citation Format

Share Document