Adipose stem cell‐derived exosomes in combination with hyaluronic acid accelerate wound healing through enhancing re‐epithelialization and vascularization

2019 ◽  
Vol 181 (4) ◽  
pp. 854-856 ◽  
Author(s):  
K. Liu ◽  
C. Chen ◽  
H. Zhang ◽  
Y. Chen ◽  
S. Zhou
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Hyaluronic Acid ◽  
Adipose Stem Cell ◽  
Accelerate Wound Healing

Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis

2021 ◽  
Vol 124 ◽  
pp. 112072
Author(s):  
Swathi Nedunchezian ◽  
Parikshit Banerjee ◽  
Chih-Yun Lee ◽  
Su-Shin Lee ◽  
Che-Wei Lin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
3D Bioprinting ◽  
Adipose Stem Cell

Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing

2020 ◽  
Vol 17 (5) ◽  
pp. 1723-1733 ◽  
Author(s):  
Qijun Lv ◽  
Junfeng Deng ◽  
You Chen ◽  
Yizhen Wang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cutaneous Wound Healing ◽  
Adipose Stem Cell ◽  
Cutaneous Wound ◽  
Human Adipose Stem Cell

scholarly journals Combination of Two Kinds of Medicated Microparticles Based on Hyaluronic Acid or Chitosan for a Wound Healing Spray Patch

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2195
Author(s):  
Angela Fabiano ◽  
Chiara Migone ◽  
Luca Cerri ◽  
Anna Maria Piras ◽  
Andrea Mezzetta ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Second Life ◽  
Olive Leaves ◽  
Waste Products ◽  
Accelerate Wound Healing ◽  
Scratch Wound ◽  
Treatment Of Wounds ◽  
Scratch Wound Healing Assay

Olive leaves extract (OLE) has been extensively studied as antioxidant and antibiotic and these characteristics make it particularly interesting for use on wounds. For this reason, the aim of this study was to introduce OLE in microparticles (MP) of hyaluronic acid (MPHA-OLE) or chitosan (MPCs-OLE) to obtain a spray patch for the treatment of wounds in anatomical areas that are difficult to protect with traditional patches. The MP were characterized for particle size and ability to protect OLE from degradation, to absorb water from wound exudate, to control OLE release from MP. The MPHA and MPCs medicated or not and mixtures of the two types in different proportions were studied in vitro on fibroblasts by the scratch wound healing assay. The MP size was always less than 5 µm, and therefore, suitable for a spray patch. The MPCs-OLE could slow down the release of OLE therefore only about 60% of the polyphenols contained in it were released after 4 h. Both MPHA and MPCs could accelerate wound healing. A 50% MPHA-OLE-50% MPCs-OLE blend was the most suitable for accelerating wound healing. The MPHA-OLE-MPCs-OLE blends studied in this work were shown to have the characteristics suitable for a spray patch, thus giving a second life to the waste products of olive growers.

Injectable silk nanofiber hydrogels as stem cell carriers to accelerate wound healing

2021 ◽  
Vol 9 (37) ◽  
pp. 7771-7781
Author(s):  
Jiadai Li ◽  
Zhaozhao Ding ◽  
Xin Zheng ◽  
Guozhong Lu ◽  
Qiang Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Hair Follicle ◽  
Cell Behaviors ◽  
Accelerate Wound Healing ◽  
Cell Carriers

Injectable silk nanofiber hdyrogels were used to load stem cells and regulate cell behaviors effectively. The stem cell–laden silk hydrogels accelerated wound healing with higher quality and hair follicle regeneration.

scholarly journals Thiolated Carboxymethyl-Hyaluronic-Acid-Based Biomaterials Enhance Wound Healing in Rats, Dogs, and Horses

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Guanghui Yang ◽  
Glenn D. Prestwich ◽  
Brenda K. Mann
Keyword(s):  
Wound Healing ◽  
Veterinary Medicine ◽  
Hyaluronic Acid ◽  
Wound Closure ◽  
Keratinocyte Proliferation ◽  
Accelerate Wound Healing ◽  
Multiple Species ◽  
Enhance Wound Healing

The progression of wound healing is a complicated but well-known process involving many factors, yet there are few products on the market that enhance and accelerate wound healing. This is particularly problematic in veterinary medicine where multiple species must be treated and large animals heal slower, oftentimes with complicating factors such as the development of exuberant granulation tissue. In this study a crosslinked-hyaluronic-acid (HA-) based biomaterial was used to treat wounds on multiple species: rats, dogs, and horses. The base molecule, thiolated carboxymethyl HA, was first found to increase keratinocyte proliferation in vitro. Crosslinked gels and films were then both found to enhance the rate of wound healing in rats and resulted in thicker epidermis than untreated controls. Crosslinked films were used to treat wounds on forelimbs of dogs and horses. Although wounds healed slower compared to rats, the films again enhanced wound healing compared to untreated controls, both in terms of wound closure and quality of tissue. This study indicates that these crosslinked HA-based biomaterials enhance wound healing across multiple species and therefore may prove particularly useful in veterinary medicine. Reduced wound closure times and better quality of healed tissue would decrease risk of infection and pain associated with open wounds.

scholarly journals Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing

2017 ◽  
Vol 137 (7) ◽  
pp. 1541-1551 ◽  
Author(s):  
Lucília Pereira da Silva ◽  
Tírcia Carlos Santos ◽  
Daniel Barreira Rodrigues ◽  
Rogério Pedro Pirraco ◽  
Mariana Teixeira Cerqueira ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Hyaluronic Acid ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals The Effects of Cytokines in Adipose Stem Cell-Conditioned Medium on the Migration and Proliferation of Skin FibroblastsIn Vitro

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Jiajia Zhao ◽  
Li Hu ◽  
Jiarong Liu ◽  
Niya Gong ◽  
Lili Chen
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Conditioned Medium ◽  
Healing Process ◽  
Dermal Fibroblasts ◽  
Wound Healing Process ◽  
Adipose Stem Cell ◽  
And Migration ◽  
Cell Conditioned Medium ◽  
Proliferation And Migration

Although adipose stem cell-conditioned medium (ASC-CM) has demonstrated the effect of promoting the cutaneous wound healing, the mechanism for this response on the effector cells (e.g., dermal fibroblasts) during the process remains to be determined. In this study, we aim to investigate the types and contents of cytokines in ASC-CM and the effects of some kinds of common cytokines in ASC-CM, such as EGF, PDGF-AA, VEGF, and bFGF, on dermal fibroblasts proliferation and migration in wound healing process. Results showed that these four cytokines had high concentrations in ASC-CM. The migration of skin fibroblasts could be significantly stimulated by VEGF, bFGF, and PDGF-AA, and the proliferation could be significantly stimulated by bFGF and EGF in ASC-CM. Additionally, ASC-CM had more obvious promoting effect on fibroblasts proliferation and migration than single cytokine. These observations suggested that ASC-CM played an important role in the cutaneous injury partly by the synergistic actions of several cytokines in promoting dermal fibroblasts proliferation and migration, and ASC-CM was more adaptive than each single cytokine to be applied in promoting the wound healing.

Adipose-derived stem cell-containing hyaluronic acid/alginate hydrogel improves vocal fold wound healing

2013 ◽  
Vol 124 (3) ◽  
pp. E64-E72 ◽  
Author(s):  
Young-Mo Kim ◽  
Se H. Oh ◽  
Jeong-Seok Choi ◽  
Songyi Lee ◽  
Jeong C. Ra ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Hyaluronic Acid ◽  
Vocal Fold ◽  
Alginate Hydrogel ◽  
Adipose Derived Stem Cell

scholarly journals PERAN HEPARIN DALAM ANGIOGENESIS, EPITELIALISASI DAN PENYEMBUHAN LUKA BAKAR

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
Ruby Riana Asparini
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Cell Growth ◽  
Growth And Development ◽  
Dermatan Sulfate ◽  
Accelerate Wound Healing ◽  
Small Doses ◽  
Anti Inflammatory ◽  
Therapy Treatment

Heparin was initially used in small doses as an anticoagulant in the treatment of burns. It turned out that in addition to the anticoagulant, heparin in larger doses can be used as an anti-inflammatory, accelerate angiogenesis (Polykratis, et al., 2004), cell growth and development (Sasisekharan and Venkataraman, 2000) so as to accelerate wound healing (Saliba, 2001; Galvan , 1996). In some countries heparin has been used as a standard therapy treatment of burns (Saliba, 2001). Heparin is one of highest endogenous glycosaminoglycans (GAGs) besides heparan sulfate (HS), keratin sulfate, dermatan sulfate, chondroitin 4-sulfate, chondroitinHS-6-sulfate and hyaluronic acid. heparin are the most acid and are highly sulfated, is the most GAGs widely used in burns as anti-inflammatory, to reduce edema, enhance angiogenesis and accelerate epitelialization (Saliba, 2001). Several studies have revealed the role of heparin in the treatment of burns. Keywords : Heparin, angiogenesis, epitelialization, treatment of burns

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