Health‐related Research Ethics and Social Value: Antibiotic Resistance Intervention Research and Pragmatic Risks

Bioethics ◽  
2019 ◽  
Vol 33 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Christian Munthe ◽  
Niels Nijsingh ◽  
Karl Fine Licht ◽  
D.G. Joakim Larsson
Keyword(s):  
Antibiotic Resistance ◽  
Research Ethics ◽  
Intervention Research ◽  
Social Value ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

scholarly journals Strengthening ethics committees for health-related research in sub-Saharan Africa: a scoping review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e046546
Author(s):  
Val Thurtle ◽  
Andy JM Leather ◽  
Haja Wurie ◽  
Edward Foday ◽  
Mohamed Samai ◽  
...  
Keyword(s):  
Research Ethics ◽  
Scoping Review ◽  
Low Income ◽  
Ethics Committees ◽  
Sub Saharan Africa ◽  
Research Ethics Committees ◽  
Related Research ◽  
Health Related Research ◽  
Health Related ◽  
Sub Saharan

IntroductionHealth research in low-income and middle-income countries, which face the greatest burden of disease, is a vital component of efforts to combat global health inequality. With increased research, there has also been concern about ethical and regulatory issues and the state of research ethics committees, with various attempts to strengthen them. This scoping review examines the literature on ethics committees for health-related research in sub-Saharan Africa, with a focus on regulatory governance and leadership, administrative and financial capacity, and conduct of ethical reviews.Methods and analysisWe will use the methodological approach proposed by Arksey and O’Malley and adapted by Levac et al and the Joanna Briggs Institute. Inclusion and exclusion criteria are based on the ‘Population–Concept–Context’ framework. Literature (from January 2000 to December 2020) will be searched in multiple databases including Embase and PubMed and websites of relevant organisations. All records will be screened by applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Review flowchart: two reviewers will independently screen titles and abstracts, and full text of included records. Using an inductive approach, we will synthesise the literature, identify best practice and gaps in evidence on strengthening research ethics committees.Ethics and disseminationEthical approval is not required as the review will include only published literature. The findings will be published in a peer-reviewed journal and presented at stakeholder meetings and conferences.

In the Ruins of Babel: Pitfalls on the Way toward a Universal Language for Research Ethics and Benefit Sharing

2011 ◽  
Vol 20 (3) ◽  
pp. 341-355 ◽  
Author(s):  
JAN HELGE SOLBAKK
Keyword(s):  
Research Ethics ◽  
International Research ◽  
Benefit Sharing ◽  
Related Research ◽  
Universal Language ◽  
Thomas Pogge ◽  
Center Report ◽  
Health Related Research ◽  
Health Related ◽  
Human Rights Based Approach

At the end of a paper on international research ethics published in the July-August 2010 issue of theHastings Center Report, London and Zollman argue the need for grounding our duties in international medical and health-related research within abroadernormative framework of social, distributive, and rectificatory justice. The same goes for Thomas Pogge, who, in a whole range of publications during the past years, has argued for a human-rights-based approach to international research. In a thought-provoking paper in the June 2010 issue of theAmerican Journal of Bioethics,Angela J. Ballantyne argues that “the global bioethics priority” in medical and health-related research ethics today is how to do researchfairlyin anunjustworld.

scholarly journals Internalization of Phospholipid-Coated Gold Nanoparticles

Crystals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 544
Author(s):  
Lindsay J. Shearer ◽  
Nils O. Petersen
Keyword(s):  
Gold Nanoparticles ◽  
A549 Cells ◽  
Cell Types ◽  
Endocytic Pathway ◽  
Cell Entry ◽  
Potential Drug ◽  
Cell Type ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

Gold nanoparticles are used in health-related research; however, their effectiveness appears to depend on how well they are internalized and where they are destined to travel. Internalization in cells is efficient if the gold nanoparticles are biocompatible, where one possible pathway of cell entry and processing is clathrin-mediated endocytosis. In this work we studied the co-localization of phospholipid-coated gold nanoparticles (PCAuNPs) with markers of the endocytic pathway (Rab and LAMP-1 proteins) in C2C12 and A549 cells and found that the internalization was consistent with clathrin-mediated endocytosis and was cell type dependent. We further found that the time evolution of uptake and disposal of these PCAuNPs was similar for both cell types, but aggregation was more significant in A549 cells. Our results support the use of these PCAuNPs as models for potential drug delivery platforms.

scholarly journals Addressing disorder in scholarly communication: Strategies from NISO 2021

2021 ◽  
pp. 1-15
Author(s):  
Jodi Schneider ◽  
Michele Avissar-Whiting ◽  
Caitlin Bakker ◽  
Hannah Heckner ◽  
Sylvain Massip ◽  
...  
Keyword(s):  
Scientific Information ◽  
Scholarly Communication ◽  
Open Science ◽  
Fake News ◽  
Science Standards ◽  
Validation And Verification ◽  
Related Research ◽  
Health Related Research ◽  
Health Related ◽  
Conference Session

Open science and preprints have invited a larger audience of readers, especially during the pandemic. Consequently, communicating the limitations and uncertainties of research to a broader public has become important over the entire information lifecycle. This paper brings together reports from the NISO Plus 2021 conference session “Misinformation and truth: from fake news to retractions to preprints”. We discuss the validation and verification of scientific information at the preprint stage in order to support sound and open science standards, at the publication stage in order to limit the spread of retracted research, and after publication, to fight fake news about health-related research by mining open access content.

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