Physical activity status of civil servants and their health-related research

2015 ◽  
pp. 417-420
Author(s):  
Yicheng Zhou ◽  
Suhua Bi ◽  
Qingle Liu ◽  
Jianyun Bao
Keyword(s):  
Physical Activity ◽  
Civil Servants ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

Best Practices for Meta-Reviews in Physical Activity and Health Research: Insights From the Physical Activity Guidelines for Americans Advisory Committee Scientific Report

2021 ◽  
pp. 1-9
Author(s):  
Linda S. Pescatello ◽  
Emily A. Hennessy ◽  
Peter T. Katzmarzyk ◽  
William E. Kraus ◽  
Anne F. Fish ◽  
...  
Keyword(s):  
Physical Activity ◽  
Advisory Committee ◽  
Best Practice ◽  
Physical Activity Guidelines ◽  
Health Related Research ◽  
Health Related ◽  
Scientific Report ◽  
Synthesis Methodology ◽  
High Level ◽  
Meta Analyses

Background: Systematic reviews (SRs) and meta-analyses (MAs) have proliferated with a concomitant increase in reviews of SRs/MAs or “meta-reviews” (MRs). As uncovered by the 2018 US Physical Activity Guidelines Advisory Committee (PAGAC), there is a paucity of best practice guidance on MRs on physical activity health-related research. This manuscript aims to fill this gap. Methods: In total, the PAGAC conducted 38 literature searches across 3 electronic databases and triaged 20,838 titles, 4913 abstracts, and 2139 full texts from which 1130 articles qualified for the PAGAC Scientific Report. Results: During the MR process, the following challenges were encountered: (1) if the SR/MA authors had limited experience in synthesis methodology, they likely did not account for risk of bias in the conclusions they reached; (2) many SRs/MAs reviewed the same primary-level studies; (3) many SRs/MAs failed to disclose effect modifier analyses; (4) source populations varied; (5) physical activity exposures were nonstandardized; and (6) dose–response effects or effect modification of the physical activity exposure could not be identified. Conclusions: Using examples from the PAGAC Scientific Report, we provide (1) a high-level introduction to MRs; (2) recommended steps in conducting a MR; (3) challenges that can be encountered; and (4) guidance in addressing these challenges.

scholarly journals Internalization of Phospholipid-Coated Gold Nanoparticles

Crystals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 544
Author(s):  
Lindsay J. Shearer ◽  
Nils O. Petersen
Keyword(s):  
Gold Nanoparticles ◽  
A549 Cells ◽  
Cell Types ◽  
Endocytic Pathway ◽  
Cell Entry ◽  
Potential Drug ◽  
Cell Type ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

Gold nanoparticles are used in health-related research; however, their effectiveness appears to depend on how well they are internalized and where they are destined to travel. Internalization in cells is efficient if the gold nanoparticles are biocompatible, where one possible pathway of cell entry and processing is clathrin-mediated endocytosis. In this work we studied the co-localization of phospholipid-coated gold nanoparticles (PCAuNPs) with markers of the endocytic pathway (Rab and LAMP-1 proteins) in C2C12 and A549 cells and found that the internalization was consistent with clathrin-mediated endocytosis and was cell type dependent. We further found that the time evolution of uptake and disposal of these PCAuNPs was similar for both cell types, but aggregation was more significant in A549 cells. Our results support the use of these PCAuNPs as models for potential drug delivery platforms.

scholarly journals Addressing disorder in scholarly communication: Strategies from NISO 2021

2021 ◽  
pp. 1-15
Author(s):  
Jodi Schneider ◽  
Michele Avissar-Whiting ◽  
Caitlin Bakker ◽  
Hannah Heckner ◽  
Sylvain Massip ◽  
...  
Keyword(s):  
Scientific Information ◽  
Scholarly Communication ◽  
Open Science ◽  
Fake News ◽  
Science Standards ◽  
Validation And Verification ◽  
Related Research ◽  
Health Related Research ◽  
Health Related ◽  
Conference Session

Open science and preprints have invited a larger audience of readers, especially during the pandemic. Consequently, communicating the limitations and uncertainties of research to a broader public has become important over the entire information lifecycle. This paper brings together reports from the NISO Plus 2021 conference session “Misinformation and truth: from fake news to retractions to preprints”. We discuss the validation and verification of scientific information at the preprint stage in order to support sound and open science standards, at the publication stage in order to limit the spread of retracted research, and after publication, to fight fake news about health-related research by mining open access content.

scholarly journals Effect of promoting current local research activities on large monitors on the population’s interest in health-related research: a randomised controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e028714
Author(s):  
Ronny Gunnarsson ◽  
Paul Cullen ◽  
Clare Heal ◽  
Jennifer Banks
Keyword(s):  
Emergency Department ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Waiting Room ◽  
Related Research ◽  
Current Health ◽  
Local Current ◽  
Health Related Research ◽  
Health Related ◽  
Randomised Controlled

ObjectiveThe objectives of this study were threefold: to estimate people’s interest in health-related research, to understand to what extent people appreciate being actively informed about current local health-related research and to investigate whether their interest can be influenced by advertising local current health-related research using large TV monitors.DesignRandomised controlled trial using a stepped wedge design.SettingThe emergency department waiting room at two public hospitals in northern Queensland, Australia.ParticipantsWaiting patients and their accompanying friends and relatives in the emergency department waiting room not requiring immediate medical attention.InterventionsA TV monitor advertising local current health-related research.Main outcome measuresOR for the effect of intervention on changing the interest in health-related research compared with a control group while adjusting for gender, age and socioeconomic standard.ResultsThe intervention significantly increased the short-term interest in health-related research with an OR of 1.3 (1.1–1.7, p=0.0063). We also noted that being female and being older was correlated to a higher interest in health-related researchConclusionsThis study found that proactive information significantly increased the general populations’ interest in health-related research. There are reasonable set up costs involved but the costs for maintaining the system were very low. Hence, it seems reasonable that research-active organisations should give much higher priority to this type of activity.Trial registration numberACTRN12617001085369

scholarly journals Patient participation in research funding: an overview of when, why and how amongst Dutch health funds

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Willemijn M. den Oudendammer ◽  
Jacquelien Noordhoek ◽  
Rebecca Y. Abma-Schouten ◽  
Lieke van Houtum ◽  
Jacqueline E. W. Broerse ◽  
...  
Keyword(s):  
Decision Making ◽  
Patient Participation ◽  
Research Funding ◽  
Strategic Decision ◽  
Patient Organisation ◽  
Related Research ◽  
Dutch Health ◽  
Health Related Research ◽  
Health Related ◽  
Stage 1

Abstract Background Patient participation in decision-making on health-related research has gained ground. Nineteen Dutch health-related research-funding organisations (HFs) have taken up the challenge to include patients in their funding process. A ‘Patient participation (PP) advisory team’ was set-up, with HF-representatives and patient advocates, who together initiated this study. We provide an overview of when, why, and how PP activities take place in HFs’ funding processes, share main challenges and identify possible solutions. Methods A qualitative research design was used. Data was gathered by questionnaires (n = 14) and semi-structured interviews (n = 18) with HF employees responsible for patient participation, followed by a workshop (n = 27) with involved employees of HFs and key players in PP from national patient organisations and research organisations. A descriptive analysis was used for the questionnaire. A semi-directed content analysis was used for the interviews and the workshop. Results Three stages can be identified in the funding process in which HFs carry out PP activities: (1) strategic decision-making about focus of research (e.g. shared research agendas); (2) call for and receipt of research proposals (e.g. mandatory inclusion of letter of recommendation from patient organisation); (3) decision-making about the funding of research proposals (e.g. patients reside in a patient panel to co-review research proposals). Main challenges identified to carry out PP activities include: how to accommodate diversity of the patient body (mainly encountered in stage 1 and 3); to what extent should patients receive training to successfully participate (mainly encountered in stage 1 and 3); and who is responsible for patient-researcher dialogues (mainly encountered in stage 1 and 2). All nineteen HFs agree that patients should be included in at least one stage of the funding process for health-related research. CONCLUSION: Further broadening and optimising patient involvement is still needed. The proposed solutions to the identified challenges could serve as inspiration for national and international research funding foundations that aim to structurally include patients in their funding process.

scholarly journals Metallomics in environmental and health related research: Current status and perspectives

2012 ◽  
Vol 58 (2) ◽  
pp. 169-176 ◽  
Author(s):  
LiGang Hu ◽  
Bin He ◽  
YuChuan Wang ◽  
GuiBin Jiang ◽  
HongZhe Sun
Keyword(s):  
Current Status ◽  
Related Research ◽  
Health Related Research ◽  
Health Related
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