Systematic review and meta‐analysis: the incidence and prevalence of paediatric coeliac disease across Europe

2021 ◽  
Author(s):  
Stephen E. Roberts ◽  
Sian Morrison‐Rees ◽  
Nikhil Thapar ◽  
Marc A. Benninga ◽  
Osvaldo Borrelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Meta Analysis

scholarly journals Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 142 ◽  
Author(s):  
Emma Clappison ◽  
Marios Hadjivassiliou ◽  
Panagiotis Zis
Keyword(s):  
Systematic Review ◽  
Eating Disorders ◽  
Coeliac Disease ◽  
Psychiatric Disorders ◽  
Meta Analysis ◽  
Hyperactivity Disorder ◽  
Increased Risk ◽  
Meta Analyses ◽  
Psychiatric Manifestations ◽  
The Relationship

Background: Coeliac disease (CD) is increasingly prevalent and is associated with both gastrointestinal (GI) and extra-intestinal manifestations. Psychiatric disorders are amongst extra-intestinal manifestations proposed. The relationship between CD and such psychiatric disorders is not well recognised or understood. Aim: The aim of this systematic review and meta-analysis was to provide a greater understanding of the existing evidence and theories surrounding psychiatric manifestations of CD. Methodology: An online literature search using PubMed was conducted, the prevalence data for both CD and psychiatric disorders was extracted from eligible articles. Meta analyses on odds ratios were also performed. Results: A total of 37 articles were included in this review. A significant increase in risk was detected for autistic spectrum disorder (OR 1.53, 95% CI 1.24–1.88, p < 0.0001), attention deficit hyperactivity disorder (OR 1.39, 95% CI 1.18–1.63, p < 0.0001), depression (OR 2.17, 95% CI 2.17–11.15, p < 0.0001), anxiety (OR 6.03, 95% CI 2.22–16.35, p < 0.0001), and eating disorders (OR 1.62, 95% CI 1.37–1.91, p < 0.00001) amongst the CD population compared to healthy controls. No significant differences were found for bipolar disorder (OR 2.35, 95% CI 2.29–19.21, p = 0.43) or schizophrenia (OR 0.46, 95% CI 0.02–10.18, p = 0.62). Conclusion: CD is associated with an increased risk of depression, anxiety, eating disorders as well as ASD and ADHD. More research is required to investigate specific biological explanations as well as any effect of gluten free diet.

Systematic review with meta-analysis: early infant feeding and coeliac disease - update 2015

2015 ◽  
Vol 41 (11) ◽  
pp. 1038-1054 ◽  
Author(s):  
H. Szajewska ◽  
R. Shamir ◽  
A. Chmielewska ◽  
M. Pieścik-Lech ◽  
R. Auricchio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Infant Feeding ◽  
Meta Analysis ◽  
Early Infant

The neurology of coeliac disease in childhood: what is the evidence? A systematic review and meta-analysis

2010 ◽  
Vol 52 (8) ◽  
pp. 700-707 ◽  
Author(s):  
ELENA LIONETTI ◽  
RUGGIERO FRANCAVILLA ◽  
PIERO PAVONE ◽  
LORENZO PAVONE ◽  
TERESA FRANCAVILLA ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Meta Analysis

scholarly journals Coeliac disease and hypertransaminasaemia: a systematic review and meta-analysis

Gut ◽  
2011 ◽  
Vol 60 (Suppl 1) ◽  
pp. A18-A18
Author(s):  
A. Sainsbury ◽  
D. S. Sanders ◽  
A. C. Ford
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Meta Analysis

scholarly journals Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1950 ◽  
Author(s):  
Mercedes Castaño ◽  
Rubén Gómez-Gordo ◽  
David Cuevas ◽  
Concepción Núñez
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Data Extraction ◽  
Meta Analysis ◽  
Numerical Data ◽  
Current Data ◽  
Small Sample ◽  
Unexplained Infertility ◽  
Intestinal Biopsy ◽  
Sample Sizes

We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%–1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women.

scholarly journals Strength of the association between Turner syndrome and coeliac disease: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e037478
Author(s):  
Ghada S M Al-Bluwi ◽  
Asma H Alnababteh ◽  
Saif Al-Shamsi ◽  
Rami H Al-Rifai
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Coeliac Disease ◽  
Turner Syndrome ◽  
Meta Analysis ◽  
Healthcare Providers ◽  
Autoimmune Disorder ◽  
Epidemiological Studies ◽  
Eligibility Criteria ◽  
Chromosomal Disorders

IntroductionCoeliac disease (CD) is a genetic autoimmune disorder characterised by a permanent sensitivity to the gluten contained in some grains. Certain patient groups are considered high risk for the development of CD, including, but not limited to, those with chromosomal disorders such as Turner syndrome (TS). Here, we present a protocol for a systematic review and meta-analysis that aims to comprehensively summarise the literature, and quantitatively estimate the weighted strength of the association between TS and CD.Methods and analysisOur protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines. We will search PubMed, Scopus, Web of Science and Embase databases for relevant articles. Variant and broad search terms will be selected for identifying epidemiological studies reporting on the crude and/or adjusted association between TS and CD. Retrieved citations will be screened, and data from the eligible research reports against specific eligibility criteria will be extracted. We will then assess the risk of bias associated with the eligible studies using the Newcastle-Ottawa Scale. The overall weighted strength of the pooled association will be quantified using the random-effects model.Ethics and disseminationThis review will use data from published literature; hence, ethical approval will not be needed. The resulting review will be the first to produce a comprehensive synthesis of the strength of the association between TS and CD. The results will be disseminated through a peer-reviewed journal as well as in local and international conferences and symposiums. Results dissemination would help healthcare providers and policy-makers to make informed decisions regarding the diagnosis and management of CD in high-risk individuals.PROSPERO registration numberCRD42019131881, dated 3 September 2019.

scholarly journals Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e038994
Author(s):  
Martha Maria Christine Elwenspoek ◽  
Joni Jackson ◽  
Sarah Dawson ◽  
Hazel Everitt ◽  
Peter Gillett ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Prediction Models ◽  
Data Extraction ◽  
Meta Analysis ◽  
Case Finding ◽  
Endoscopic Biopsy ◽  
Cochrane Library ◽  
Ethical Approval ◽  
Registration Number

IntroductionCoeliac disease (CD) is a systemic immune-mediated disorder triggered by gluten in genetically predisposed individuals. CD is diagnosed using a combination of serology tests and endoscopic biopsy of the small intestine. However, because of non-specific symptoms and heterogeneous clinical presentation, diagnosing CD is challenging. Early detection of CD through improved case-finding strategies can improve the response to a gluten-free diet, patients’ quality of life and potentially reduce the risk of complications. However, there is a lack of consensus in which groups may benefit from active case-finding.Methods and analysisWe will perform a systematic review to determine the accuracy of diagnostic indicators (such as symptoms and risk factors) for CD in adults and children, and thus can help identify patients who should be offered CD testing. MEDLINE, Embase, Cochrane Library and Web of Science will be searched from 1997 until 2020. Screening will be performed in duplicate. Data extraction will be performed by one and checked by a second reviewer. Disagreements will be resolved through discussion or referral to a third reviewer. We will produce a narrative summary of identified prediction models. Studies, where 2×2 data can be extracted or reconstructed, will be treated as diagnostic accuracy studies, that is, the diagnostic indicators are the index tests and CD serology and/or biopsy is the reference standard. For each diagnostic indicator, we will perform a bivariate random-effects meta-analysis of the sensitivity and specificity.Ethics and disseminationResults will be reported in peer-reviewed journals, academic and public presentations and social media. We will convene an implementation panel to advise on the optimum strategy for enhanced dissemination. We will discuss findings with Coeliac UK to help with dissemination to patients. Ethical approval is not applicable, as this is a systematic review and no research participants will be involved.PROSPERO registration numberCRD42020170766.

PA13 THE NEUROLOGY OF COELIAC DISEASE IN CHILDHOOD: WHAT IS THE EVIDENCE? A SYSTEMATIC REVIEW AND META-ANALYSIS

2010 ◽  
Vol 42 ◽  
pp. S347
Author(s):  
E. Lionetti ◽  
L. Pavone ◽  
M. Ruggieri ◽  
A. Pulvirenti ◽  
R. Francavilla
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Meta Analysis
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