The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer

Apmis ◽  
2014 ◽  
Vol 122 (12) ◽  
pp. 1223-1229 ◽  
Author(s):  
Noyko Stanilov ◽  
Lyuba Miteva ◽  
Jovcho Jovchev ◽  
Geo Cirovski ◽  
Spaska Stanilova
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Prognostic Value of Preoperative Serum Levels of CEA and CA19-9 in Patients with Colorectal Cancer

2007 ◽  
Vol 23 (5) ◽  
pp. 338
Author(s):  
Byong Ku Bae ◽  
Seong Woo Hong ◽  
Yeo Goo Chang ◽  
Koo Yong Hahn ◽  
In Wook Paik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Preoperative Carbohydrate Antigen 195 (CA195) and CEA Serum Levels as Prognostic Factors in Patients with Colorectal Cancer

1998 ◽  
Vol 13 (3) ◽  
pp. 158-164 ◽  
Author(s):  
A. Andicoechea ◽  
F. Vizoso ◽  
E. Alexandre ◽  
E. Cuesta ◽  
M. Cruz Díez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Value ◽  
Serum Levels ◽  
Tumor Location ◽  
Carbohydrate Antigen ◽  
Primary Colorectal Cancer ◽  
Preoperative Serum ◽  
The Mean

We evaluated in 214 patients with primary colorectal cancer the prognostic value of the preoperative serum levels of CEA and CA195. For CEA these levels were above the cutoff of 6 ng/ml in 31.3% of patients, whereas for CA195 they were higher than 12 U/ml in 35.9% of patients. The simultaneous use of both antigens increased the sensitivity to 49%, which was significantly higher than that of CEA (p<0.001) and CA195 (p<0.01) taken singly. The mean preoperative CEA levels were significantly (p<0.001) correlated with Dukes’ stage only, while there was a significant correlation between preoperative serum levels of CA195 and Dukes’ stage (p<0.001), grade of differentiation (p<0.01) and tumor location (p<0.05). The results indicated that high preoperative serum levels of CEA and CA195 were associated with a shorter overall survival (p<0.0001). In addition, separate Cox multivariate analysis showed that preoperative CA195 was, after Dukes’ stage, the strongest factor to predict overall survival (p<0.0001).

scholarly journals Elevated Serum Endothelin-1 Levels in Patients with Colorectal Cancer; Relevance for Prognosis

2000 ◽  
Vol 15 (4) ◽  
pp. 288-293 ◽  
Author(s):  
C.F. Peeters ◽  
C.M. Thomas ◽  
F.C. Sweep ◽  
P.N. Span ◽  
T. Wobbes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Prognostic Value ◽  
Elevated Serum ◽  
Serum Levels ◽  
Endothelin 1 ◽  
Kaplan Meier ◽  
Preoperative Serum ◽  
Potent Vasoconstrictor ◽  
Group B

Background It has been demonstrated that the Doppler Perfusion Index (DPI) is increased in patients who are at risk of developing liver metastases from colorectal cancer. It has been postulated that a circulating hormonal factor is involved in the relative vasoconstriction throughout the splanchnic bed. Endothelin-1 (ET-1), a potent vasoconstrictor which has been associated with tumor growth and is produced by colorectal tumors, may play an important role in this phenomenon. In this paper the prognostic value of serum ET-1 in colorectal cancer is discussed. Methods Preoperative serum levels of ET-1 were assessed in three groups of patients: group A underwent resection of the colorectal tumor and remained free of recurrence (n=20); group B developed metachronous liver metastases at least six months after colorectal resection (n=14); and group C presented with colorectal cancer and synchronous liver metastases (n=22). Results The mean (SD) serum ET-1 levels in groups A, B and C were 1.59 (0.41) pmol/L, 1.70 (0.32) pmol/L and 1.85 (0.47) pmol/L, respectively. These values were significantly different from those of healthy controls (1.22 (0.31), p<0.05). Kaplan-Meier analyses revealed no prognostic value of preoperative serum ET-1 levels. Conclusions These preliminary results demonstrate that serum ET-1 levels are raised in patients with colorectal cancer. Serum ET-1 levels do not seem to be of prognostic value for survival.

scholarly journals Preoperative serum levels of CEA and CA 242 in colorectal cancer

1995 ◽  
Vol 71 (4) ◽  
pp. 868-872 ◽  
Author(s):  
M Carpelan-Holmström ◽  
C Haglund ◽  
P Kuusela ◽  
H Järvinen ◽  
PJ Roberts
Keyword(s):  
Colorectal Cancer ◽  
Serum Levels ◽  
Ca 242 ◽  
Preoperative Serum

325. The prognostic value of serum levels of CCL2 and CCL5 in colorectal cancer

2016 ◽  
Vol 42 (9) ◽  
pp. S148
Author(s):  
K. Brzuszkiewicz ◽  
S. Pietruszka ◽  
A. Paszko ◽  
A. Szczepanik ◽  
M. Gądek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels

scholarly journals Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer

2014 ◽  
Vol 71 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Elena Kostova ◽  
Maja Slaninka-Miceska ◽  
Nikola Labacevski ◽  
Krume Jakovski ◽  
Jasmina Trojachanec ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Matrix Metalloproteinases ◽  
Tumor Invasion ◽  
Tumor Tissue ◽  
Serum Levels ◽  
Basement Membranes ◽  
Matrix Proteins ◽  
Immunohistochemical Expression ◽  
Preoperative Serum ◽  
Cell Expression

Background/Aim. Matrix metalloproteinases (MMPs) are perceived to play a key role in tumor invasion and metastasis by their capacity to degrade basement membranes and extracellular matrix proteins. The aim of this study was to investigate the expressions of MMP-2, MMP-7 and MMP-9 in tumor tissue and their relation to clinicopathologic features in patients with colorectal cancer. Methods. Specimens of resected colorectal cancer and surrounding normal tissue of 82 patients were immunohistochemically stained for MMP-2, MMP-7 and MMP-9. The results of immunohistochemical expression of MMPs were correlated with some clinical and pathologic parameters. Results. Immunohistochemical expression of MMP-2 was more frequent in the patients with higher preoperative serum levels of carcinoembryonic antigen (CEA) (p = 0.047), MMP-2 (p = 0.018), MMP-9 (p = 0.036) and in those with lymph node metastasis (p = 0.018) and the advanced stage of the disease (p = 0.046). Expression of MMP-7 was more frequent in the patients with elevated preoperative serum levels of: CEA (p = 0.012), MMP-7 (p = 0.036), MMP-9 (p = 0.023) and with deeply invasive neoplasms (p = 0.027). MMP-9 cell expression was in a positive correlation with elevated preoperative serum levels of: CEA (p = 0.013), MMP-2 (p = 0.012), MMP-9 (p = 0.018) and depth of CRC invasion, i.e. Tparameter (p = 0.027). Conclusion. Immunohistochemical expression of MMPs is a useful indicator of the disease development and progression in patients with colorectal cancer.

scholarly journals The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study

2021 ◽  
Author(s):  
Long Bai ◽  
Ze-Yu Lin ◽  
Yun-Xin Lu ◽  
Qin Chen ◽  
Han Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Liver Metastases ◽  
Peer Review ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Curative Intent ◽  
Preoperative Serum ◽  
Colorectal Cancer Patients

Abstract Background. The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of curative-intent surgery for colorectal liver metastases (CRLM).Patients and Methods. 580 consecutive metastatic colorectal cancer patients who underwent curative-intent CRLM resection from Blinded for peer review (434 patients) and Blinded for peer review (146 patients) treated in 2000-2019 were enrolled. Overall survival (OS) was the primary endpoint. Cox regression model was performed to identify the prognostic values of preoperative serum LDH levels and other clinicopathology variables. A modification of the established Fong CRS scoring system comprising LDH was developed within this Chinese population.Results. At the median follow-up time of 60.5 months, and median OS was 59.5 months in the pooled cohort. In the multivariate analysis, preoperative LDH > upper limit of normal (250 U/L) was the strongest independent prognostic factor for OS (HR 1.73, 95% confidence interval [CI], 1.22-2.44; P < .001). Patients with elevated LDH levels showed impaired OS than patients with normal LDH levels (27.6 months vs. 68.8 months). Five-year survival rates were 53.7% and 22.5% in the LDH-normal group and LDH-high group, respectively. Similar results were also confirmed in each cohort. In the subgroup analysis, LDH could distinguish the survival regardless of most established prognostic factors (number and size of CRLM, surgical margin, extrahepatic metastases, CEA and CA19-9 levels, etc.). Integrating LDH into the Fong score contributed to an improvement in the predictive value. Conclusion. Our study implicates serum LDH as a reliable and independent laboratory biomarker to predict the clinical outcome of curative-intent surgery for CRLM. Composite of LDH and Fong score is a potential stratification tool for CRLM resection. Prospective, international studies are needed to validate these results across diverse populations.

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