325. The prognostic value of serum levels of CCL2 and CCL5 in colorectal cancer

2016 ◽  
Vol 42 (9) ◽  
pp. S148
Author(s):  
K. Brzuszkiewicz ◽  
S. Pietruszka ◽  
A. Paszko ◽  
A. Szczepanik ◽  
M. Gądek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels

The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer

Apmis ◽  
2014 ◽  
Vol 122 (12) ◽  
pp. 1223-1229 ◽  
Author(s):  
Noyko Stanilov ◽  
Lyuba Miteva ◽  
Jovcho Jovchev ◽  
Geo Cirovski ◽  
Spaska Stanilova
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Prognostic Value of Preoperative Serum Levels of CEA and CA19-9 in Patients with Colorectal Cancer

2007 ◽  
Vol 23 (5) ◽  
pp. 338
Author(s):  
Byong Ku Bae ◽  
Seong Woo Hong ◽  
Yeo Goo Chang ◽  
Koo Yong Hahn ◽  
In Wook Paik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Preoperative Carbohydrate Antigen 195 (CA195) and CEA Serum Levels as Prognostic Factors in Patients with Colorectal Cancer

1998 ◽  
Vol 13 (3) ◽  
pp. 158-164 ◽  
Author(s):  
A. Andicoechea ◽  
F. Vizoso ◽  
E. Alexandre ◽  
E. Cuesta ◽  
M. Cruz Díez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Value ◽  
Serum Levels ◽  
Tumor Location ◽  
Carbohydrate Antigen ◽  
Primary Colorectal Cancer ◽  
Preoperative Serum ◽  
The Mean

We evaluated in 214 patients with primary colorectal cancer the prognostic value of the preoperative serum levels of CEA and CA195. For CEA these levels were above the cutoff of 6 ng/ml in 31.3% of patients, whereas for CA195 they were higher than 12 U/ml in 35.9% of patients. The simultaneous use of both antigens increased the sensitivity to 49%, which was significantly higher than that of CEA (p<0.001) and CA195 (p<0.01) taken singly. The mean preoperative CEA levels were significantly (p<0.001) correlated with Dukes’ stage only, while there was a significant correlation between preoperative serum levels of CA195 and Dukes’ stage (p<0.001), grade of differentiation (p<0.01) and tumor location (p<0.05). The results indicated that high preoperative serum levels of CEA and CA195 were associated with a shorter overall survival (p<0.0001). In addition, separate Cox multivariate analysis showed that preoperative CA195 was, after Dukes’ stage, the strongest factor to predict overall survival (p<0.0001).

scholarly journals Elevated Serum Endothelin-1 Levels in Patients with Colorectal Cancer; Relevance for Prognosis

2000 ◽  
Vol 15 (4) ◽  
pp. 288-293 ◽  
Author(s):  
C.F. Peeters ◽  
C.M. Thomas ◽  
F.C. Sweep ◽  
P.N. Span ◽  
T. Wobbes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Prognostic Value ◽  
Elevated Serum ◽  
Serum Levels ◽  
Endothelin 1 ◽  
Kaplan Meier ◽  
Preoperative Serum ◽  
Potent Vasoconstrictor ◽  
Group B

Background It has been demonstrated that the Doppler Perfusion Index (DPI) is increased in patients who are at risk of developing liver metastases from colorectal cancer. It has been postulated that a circulating hormonal factor is involved in the relative vasoconstriction throughout the splanchnic bed. Endothelin-1 (ET-1), a potent vasoconstrictor which has been associated with tumor growth and is produced by colorectal tumors, may play an important role in this phenomenon. In this paper the prognostic value of serum ET-1 in colorectal cancer is discussed. Methods Preoperative serum levels of ET-1 were assessed in three groups of patients: group A underwent resection of the colorectal tumor and remained free of recurrence (n=20); group B developed metachronous liver metastases at least six months after colorectal resection (n=14); and group C presented with colorectal cancer and synchronous liver metastases (n=22). Results The mean (SD) serum ET-1 levels in groups A, B and C were 1.59 (0.41) pmol/L, 1.70 (0.32) pmol/L and 1.85 (0.47) pmol/L, respectively. These values were significantly different from those of healthy controls (1.22 (0.31), p<0.05). Kaplan-Meier analyses revealed no prognostic value of preoperative serum ET-1 levels. Conclusions These preliminary results demonstrate that serum ET-1 levels are raised in patients with colorectal cancer. Serum ET-1 levels do not seem to be of prognostic value for survival.

Prognostic Value of Erythrocyte Sedimentation Rate in Patients with Colorectal Cancer

2008 ◽  
Vol 24 (5) ◽  
pp. 351
Author(s):  
Young Ki Kim ◽  
Seong Woo Hong ◽  
Jung Woo Chun ◽  
Yeo Goo Chang ◽  
In Wook Paik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Prognostic Value ◽  
Erythrocyte Sedimentation

scholarly journals Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Peter W. Eide ◽  
Seyed H. Moosavi ◽  
Ina A. Eilertsen ◽  
Tuva H. Brunsell ◽  
Jonas Langerud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Principal Components ◽  
Prognostic Value ◽  
Tumor Heterogeneity ◽  
Molecular Subtypes ◽  
R Package ◽  
Data Set ◽  
Primary Tumors ◽  
External Data

AbstractGene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes (CMS) for metastatic cancers is not well known. We investigated the metastatic heterogeneity of CMS. The best approach to subtype translation was delineated by comparisons of transcriptomic profiles from 317 primary tumors and 295 liver metastases, including multi-metastatic samples from 45 patients and 14 primary-metastasis sets. Associations were validated in an external data set (n = 618). Projection of metastases onto principal components of primary tumors showed that metastases were depleted of CMS1-immune/CMS3-metabolic signals, enriched for CMS4-mesenchymal/stromal signals, and heavily influenced by the microenvironment. The tailored CMS classifier (available in an updated version of the R package CMScaller) therefore implemented an approach to regress out the liver tissue background. The majority of classified metastases were either CMS2 or CMS4. Nonetheless, subtype switching and inter-metastatic CMS heterogeneity were frequent and increased with sampling intensity. Poor-prognostic value of CMS1/3 metastases was consistent in the context of intra-patient tumor heterogeneity.

scholarly journals 126P Prognostic value of blood-based fibrosis biomarkers in patients with metastatic colorectal cancer receiving chemotherapy and bevacizumab

2020 ◽  
Vol 31 ◽  
pp. S290
Author(s):  
N.I. Nissen ◽  
S. Kehlet ◽  
M.K. Boisen ◽  
M. Liljefors ◽  
C. Jensen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Prognostic Value
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