scholarly journals Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer

2014 ◽  
Vol 71 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Elena Kostova ◽  
Maja Slaninka-Miceska ◽  
Nikola Labacevski ◽  
Krume Jakovski ◽  
Jasmina Trojachanec ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Matrix Metalloproteinases ◽  
Tumor Invasion ◽  
Tumor Tissue ◽  
Serum Levels ◽  
Basement Membranes ◽  
Matrix Proteins ◽  
Immunohistochemical Expression ◽  
Preoperative Serum ◽  
Cell Expression

Background/Aim. Matrix metalloproteinases (MMPs) are perceived to play a key role in tumor invasion and metastasis by their capacity to degrade basement membranes and extracellular matrix proteins. The aim of this study was to investigate the expressions of MMP-2, MMP-7 and MMP-9 in tumor tissue and their relation to clinicopathologic features in patients with colorectal cancer. Methods. Specimens of resected colorectal cancer and surrounding normal tissue of 82 patients were immunohistochemically stained for MMP-2, MMP-7 and MMP-9. The results of immunohistochemical expression of MMPs were correlated with some clinical and pathologic parameters. Results. Immunohistochemical expression of MMP-2 was more frequent in the patients with higher preoperative serum levels of carcinoembryonic antigen (CEA) (p = 0.047), MMP-2 (p = 0.018), MMP-9 (p = 0.036) and in those with lymph node metastasis (p = 0.018) and the advanced stage of the disease (p = 0.046). Expression of MMP-7 was more frequent in the patients with elevated preoperative serum levels of: CEA (p = 0.012), MMP-7 (p = 0.036), MMP-9 (p = 0.023) and with deeply invasive neoplasms (p = 0.027). MMP-9 cell expression was in a positive correlation with elevated preoperative serum levels of: CEA (p = 0.013), MMP-2 (p = 0.012), MMP-9 (p = 0.018) and depth of CRC invasion, i.e. Tparameter (p = 0.027). Conclusion. Immunohistochemical expression of MMPs is a useful indicator of the disease development and progression in patients with colorectal cancer.

scholarly journals Preoperative serum levels of CEA and CA 242 in colorectal cancer

1995 ◽  
Vol 71 (4) ◽  
pp. 868-872 ◽  
Author(s):  
M Carpelan-Holmström ◽  
C Haglund ◽  
P Kuusela ◽  
H Järvinen ◽  
PJ Roberts
Keyword(s):  
Colorectal Cancer ◽  
Serum Levels ◽  
Ca 242 ◽  
Preoperative Serum

The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer

Apmis ◽  
2014 ◽  
Vol 122 (12) ◽  
pp. 1223-1229 ◽  
Author(s):  
Noyko Stanilov ◽  
Lyuba Miteva ◽  
Jovcho Jovchev ◽  
Geo Cirovski ◽  
Spaska Stanilova
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

scholarly journals EXPRESSION OF IGFBP-6 IN COLORECTAL CANCER: THE RELATION WITH INSULIN-LIKE GROWTH FACTOR RECEPTOR, ADIPONECTIN LEVEL AND ITS RECEPTORS

2015 ◽  
Vol 14 (6) ◽  
pp. 87-93
Author(s):  
N. V. Yunusova ◽  
L. V. Spirina ◽  
S. G. Afanasiev ◽  
I. V. Kondakova
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Tumor Invasion ◽  
Tumor Tissue ◽  
Adiponectin Level ◽  
Growth Factor Receptor ◽  
Serum Adiponectin ◽  
Insulin Like Growth Factor ◽  
Serum Adiponectin Level ◽  
Cancer Tissues

The aim of the study was to investigate the expression of insulin-like growth factor binding protein 6 (IGFBP-6) in cancer tissues in relation with clinical and morphological parameters, IGF-IR expression, serum adiponectin level and its receptors (AdipoR1, AdipoR2) in patients with colorectal cancer.Material and Methods. The study included 31 patients with colorectal cancer (T2–4N0–2M0). Serum adiponectin level, AdipoR1 and AdipoR2 expression were evaluated with ELISA. IGF-IR expression was evaluated in tumor tissue by flow cytometry. IGFBP-6 expression was evaluated with Western blotting.Results. The dependence of IGFBP-6 expression, AdipoR1, AdipoR2 on tumor invasion and lymph nodes status were revealed. There is no association IGFBP-6 expression, AdipoR1 and AdipoR2 expression and serum adiponectin level with metabolic syndrome. The revealed positive relationships between IGFBP-6 expression and AdipoR1 expression, between IGFBP-6 expression and AdipoR2 expression, between IGF-IR and AdipoR1 expression show cross-talk between IGF-IR and adiponectin/AdipoR1 pathways in colorectal carcinomas.

scholarly journals Evaluation of serum levels of malondialdehyde and endogenous non-enzymatic antioxidants in relation to colorectal cancer stage and intestinal wall infiltration

2021 ◽  
Author(s):  
Ismar Rašić ◽  
Sandin Holjan ◽  
Vedad Papović ◽  
Sanjin Glavaš ◽  
Adi Mulabdić ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Uric Acid ◽  
Surgical Treatment ◽  
Serum Albumin ◽  
Tumor Invasion ◽  
Serum Levels ◽  
Intestinal Wall ◽  
Disease Stage ◽  
Control Group ◽  
Enzymatic Antioxidants

Introduction: Oxidative stress and lipid peroxidation are pointed as possible factors in the development of colorectal cancer (CRC). The aim of this study was to assess the serum malondialdehyde (MDA) and non-enzymatic antioxidants concentration (albumin, bilirubin, uric acid, and ferritin) and their relation with the stage and histopathologic size (pT) of CRC. Methods: One hundred and twenty patients with clinically and histopathologically confirmed CRC and the need for surgical treatment were included in a cross-sectional study. All patients were divided into groups according to the disease stage and depth of tumor invasion. The control group included 30 subjects with no signs of malignant and inflammatory bowel disease. The patients and controls did not receive vitamin supplementation. Peripheral venous blood was sampled before the surgical treatment of CRC patients and on the day of the examination of control subjects for determination of serum MDA and the concentration of the non-enzymatic antioxidants. Results: The serum levels of MDA were progressively increased in CRC patients with the highest level in the fourth stage of disease and pT4 group. Ferritin levels increased significantly with the CRC stage and decreased with the depth of bowel wall invasion. Serum albumin concentration significantly decreased with increasing stage and increasing depth of tumor invasion of the intestinal wall, while serum bilirubin level showed no change compared to the control group. Serum uric acid concentration was significantly higher in CRC patients, but no difference was observed with CRC progression. It was confirmed that serum albumin significantly negatively correlated with the CRC stage (rho = −0.649, p < 0.001), while serum MDA significantly positively correlated with the CRC stage (rho = 0.750, p < 0.001). Conclusion: These results indicate that serum MDA concentrations are related to the progression of CRC, to which the imbalance in non-enzymatic antioxidants also contributes.

Prognostic Value of Preoperative Serum Levels of CEA and CA19-9 in Patients with Colorectal Cancer

2007 ◽  
Vol 23 (5) ◽  
pp. 338
Author(s):  
Byong Ku Bae ◽  
Seong Woo Hong ◽  
Yeo Goo Chang ◽  
Koo Yong Hahn ◽  
In Wook Paik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Serum Levels ◽  
Preoperative Serum

Preoperative Carbohydrate Antigen 195 (CA195) and CEA Serum Levels as Prognostic Factors in Patients with Colorectal Cancer

1998 ◽  
Vol 13 (3) ◽  
pp. 158-164 ◽  
Author(s):  
A. Andicoechea ◽  
F. Vizoso ◽  
E. Alexandre ◽  
E. Cuesta ◽  
M. Cruz Díez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Value ◽  
Serum Levels ◽  
Tumor Location ◽  
Carbohydrate Antigen ◽  
Primary Colorectal Cancer ◽  
Preoperative Serum ◽  
The Mean

We evaluated in 214 patients with primary colorectal cancer the prognostic value of the preoperative serum levels of CEA and CA195. For CEA these levels were above the cutoff of 6 ng/ml in 31.3% of patients, whereas for CA195 they were higher than 12 U/ml in 35.9% of patients. The simultaneous use of both antigens increased the sensitivity to 49%, which was significantly higher than that of CEA (p<0.001) and CA195 (p<0.01) taken singly. The mean preoperative CEA levels were significantly (p<0.001) correlated with Dukes’ stage only, while there was a significant correlation between preoperative serum levels of CA195 and Dukes’ stage (p<0.001), grade of differentiation (p<0.01) and tumor location (p<0.05). The results indicated that high preoperative serum levels of CEA and CA195 were associated with a shorter overall survival (p<0.0001). In addition, separate Cox multivariate analysis showed that preoperative CA195 was, after Dukes’ stage, the strongest factor to predict overall survival (p<0.0001).

scholarly journals IS A STUDY OF THE LEVEL OF CARBOHYDRATE ANTIGEN (CA 19-9) EFFECTIVE IN PATIENTS WITH COLORECTAL CANCER?

2020 ◽  
Vol 66 (5) ◽  
pp. 528-534
Author(s):  
Ye. Rybakov ◽  
Mikhail Tarasov ◽  
S. Chernyshov ◽  
Marina Sukhina ◽  
V. Charikov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Perineural Invasion ◽  
Serum Levels ◽  
Lymphatic Invasion ◽  
Node Metastasis ◽  
Preoperative Serum ◽  
Invasion Stage

Objective. Саrbohydrаte antigen 19-9 (CA 19-9) is the frequently used tumor marker in the clinical setting of colorectal cancer (CRC). This study was designed to investigate the correlation between preoperative serum levels of CA 19-9 (pre-CA 19-9) and the clinicopathologic factors of patients with CRC. Patients and methods. A study was performed on 482 patients with histologically diagnosed colorectal adenocarcinoma between January 2016 and December 2017, based on retrospective collected data. The clinical data such as age, sex, size of tumor, differentiation (G), depth of tumor (T), lymph node metastasis (N), distant metastasis (M), lymphatic invasion, venous invasion, perineural invasion, stage, and preoperative serum levels of CEA (pre-CEA) and pre-CA 19-9 were obtained. These patients were classified into two groups according to pre-CA 19-9 (CA 19-9 high: H37 U/mL; CA 19-9 normal: H37 U/mL). Results. Eighty five patients among 483 patients (17.6%) with CRC showed a high pre-CA 19-9. The elevationof pre-CA 19-9 was significantly associated with size of tumor > 4.5 cm (р=0.0001), higt CEA > 5ng/ml (р<0.0001), wrong differenciation of tumor (р=0.0003), depth of tumor (р<0.0001), lymph node metastasis (р<0.0001), distant metastasis (р<0.0001), lymphatic invasion (р=0.0013), vascular invasion (р<0.0001), perineural invasion (р<0.0001), stage (р<0.0001). On multivariate analysis, high pre-CA 19-9 was shown to be independently associated with depth of tumor (р=0.05), lymph node metastasis (р=0.0006). Spearman>s correlation coefficient r between REA and CA 19-9 was 0.21 (95% CI 0.13 - 0.30; p<0.0001). Conclusion. High pre-CA 19-9 in advanced colorectal cancer might provide important information to predict the depth of tumor, lymph node metastasis.

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