scholarly journals Sterile Leukocyturia Is Associated With Interstitial Fibrosis and Tubular Atrophy in Kidney Allograft Protocol Biopsies

2014 ◽  
Vol 14 (4) ◽  
pp. 908-915 ◽  
Author(s):  
S. Coelho ◽  
F. Ortíz ◽  
R. Gelpi ◽  
P. Koskinen ◽  
N. Porta ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Kidney Allograft ◽  
Protocol Biopsies

scholarly journals Intragraft Expression of the IL-10 Gene Is Up-Regulated in Renal Protocol Biopsies with Early Interstitial Fibrosis, Tubular Atrophy, and Subclinical Rejection

2010 ◽  
Vol 176 (4) ◽  
pp. 1696-1704 ◽  
Author(s):  
Miguel Hueso ◽  
Estanis Navarro ◽  
Francesc Moreso ◽  
Francisco O'Valle ◽  
Mercè Pérez-Riba ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies ◽  
Subclinical Rejection

Expression of pro- and antifibrotic genes in protocol biopsies from renal allografts with interstitial fibrosis and tubular atrophy

2008 ◽  
Vol 69 (06) ◽  
pp. 408-416 ◽  
Author(s):  
M. Mengel ◽  
O. Bock ◽  
M. Priess ◽  
H. Haller ◽  
H. Kreipe ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Renal Allografts ◽  
Protocol Biopsies

Increased urinary cystatin C level is associated with interstitial fibrosis and tubular atrophy in kidney allograft recipients

2015 ◽  
Vol 48 (7-8) ◽  
pp. 546-549 ◽  
Author(s):  
Maria de Fátima Castro Mendes ◽  
João Victor Salgado ◽  
José de Ribamar Lima ◽  
Teresa Cristina Alves Ferreira ◽  
Gyl Eanes Barros Silva ◽  
...  
Keyword(s):  
Cystatin C ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Kidney Allograft ◽  
Urinary Cystatin C

scholarly journals P1741TACROLIMUS FAST METABOLIZERS SHOW A HIGHER PROGRESSION OF INTERTITIAL FIBROSIS AND TUBULAR ATROPHY DURING THE FIRST YEAR AFTER RENAL TRASPLANTATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Betty Chamoun Huacon ◽  
Irina Torres ◽  
Alejandra Gabaldon ◽  
Néstor Toapanta ◽  
Joana Sellares ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Univariate Analysis ◽  
First Year ◽  
Prolonged Release ◽  
Dose Ratio ◽  
Tubular Atrophy ◽  
Protocol Biopsies ◽  
The Difference ◽  
Independent Association ◽  
Allograft Loss

Abstract Background and Aims Fast tacrolimus metabolizers (expressed as the blood concentration/ dose ratio; C / D; ng / mL * mg) showed poorer renal function at 2 years, a higher incidence of nephrotoxicity and BK polyomavirus infection. Greater variability of tacrolimus trough levels (CV) from six to twelve months is associated with the appearance of HLA antibodies, interstitial fibrosis / tubular atrophy (IFTA) progression and allograft loss. We evaluate the relationship between C / D, CV and IFTA progression. Method We evaluated a cohort of 87 low immunological risk renal transplants treated with prolonged-release tacrolimus, mycophenolate mofetil and steroids. We analyzed paired protocol biopsies at 4 and 18 months. Biopsies were evaluated according to the Banff classification and the progression of IFTA was defined as the difference of ci + ct score> 0 between 18 and 4 months. The C / D ratio was calculated as the average of the value recorded at 3, 6 and 12 months of follow-up. The tacrolimus CV between 6 and 12 months was calculated using all the available determinations. Results IFTA progression was observed in 36 cases (41%). In the univariate analysis, it was found that the progression of IFTA was associated with the ci + ct score at 4 months (0.92 ± 0.94 for progressors vs. 1.89 ± 1.26 not progressors, p = 0.0003), and with the average of the C / D ratio (1.70 ± 0.73 for progressors vs. 2.28 ± 1.25 not progressors; p = 0.0144, table 1). An independent association between the C/D ratio and the progression of IFTA was observed in the multivariate analysis (OR: 0.42; 95% CI: 0.22-0.82, p = 0.027). Conclusion The results of our work suggest that fast tacrolimus metabolizers (lower C / D ratio) are more susceptible to the nephrotoxic effect of tacrolimus.

scholarly journals Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months

2009 ◽  
Vol 24 (8) ◽  
pp. 2567-2575 ◽  
Author(s):  
Andreas Scherer ◽  
Wilfried Gwinner ◽  
Michael Mengel ◽  
Torsten Kirsch ◽  
Friedrich Raulf ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies

scholarly journals Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

2021 ◽  
Author(s):  
Zhengzi Yi ◽  
Fadi Salem ◽  
Madhav C Menon ◽  
Karen Keung ◽  
Caixia Xi ◽  
...  
Keyword(s):  
Deep Learning ◽  
Interstitial Fibrosis ◽  
Periodic Acid ◽  
Graft Loss ◽  
Kidney Tissue ◽  
Tubular Atrophy ◽  
Post Transplant ◽  
Pathological Lesions ◽  
Protocol Biopsies ◽  
Tissue Compartments

Background: Interstitial fibrosis, tubular atrophy, and inflammation are major contributors to renal allograft failure. Here we seek an objective, quantitative pathological assessment of these lesions to improve predictive utility. Methods: We constructed a deep–learning–based pipeline recognizing normal vs. abnormal kidney tissue compartments and mononuclear leukocyte (MNL) infiltrates from Periodic acid–Schiff (PAS) stained slides of transplant biopsies (training: n=60, testing: n=33) that quantified pathological lesions specific for interstitium, tubules and MNL infiltration. The pipeline was applied to 789 whole slide images (WSI) from baseline (n=478, pre–implantation) and 12–month post–transplant (n=311) protocol biopsies in two independent cohorts (GoCAR: 404 patients, AUSCAD: 212 patients) of transplant recipients to correlate composite lesion features with graft loss. Results: Our model accurately recognized kidney tissue compartments and MNLs. The digital features significantly correlated with Banff scores, but were more sensitive to subtle pathological changes below the thresholds in Banff scores. The Interstitial and Tubular Abnormality Score (ITAS) in baseline samples was highly predictive of 1–year graft loss (p=2.8e–05), while a Composite Damage Score (CDS) in 12–month post–transplant protocol biopsies predicted later graft loss (p=7.3e–05). ITAS and CDS outperformed Banff scores or clinical predictors with superior graft loss prediction accuracy. High/intermediate risk groups stratified by ITAS or CDS also demonstrated significantly higher incidence of eGFR decline and subsequent graft damage. Conclusions: This deep–learning approach accurately detected and quantified pathological lesions from baseline or post–transplant biopsies, and demonstrated superior ability for prediction of post–transplant graft loss with potential application as a prevention, risk stratification or monitoring tool.

Interstitial Fibrosis and Tubular Atrophy on Protocol Biopsies at 1 Year After Renal Transplantation

2012 ◽  
Vol 44 (3) ◽  
pp. 607-609 ◽  
Author(s):  
T. Yokoyama ◽  
O. Konno ◽  
Y. Nakamura ◽  
Y. Kihara ◽  
Y. Jojima ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies

scholarly journals P1687ASSOCIATION OF URINARY MICRORNA-21-5P WITH INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY (IFTA) IN RENAL TRANSPLANT RECIPIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Michal Gniewkiewicz ◽  
Izabela Paszkowska ◽  
Jolanta Gozdowska ◽  
Katarzyna Czerwinska ◽  
Anna Sadowska-Jakubowicz ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Clinicopathological Parameters ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Tubular Atrophy ◽  
Kidney Allograft ◽  
Expression Levels ◽  
Allograft Function

Abstract Background and Aims One of the most limiting factors of long-term graft survival is chronic renal allograft dysfunction (CAD). The major hallmarks of CAD are interstitial fibrosis and tubular atrophy (IFTA). MicroRNAs (miRNAs) are 19-25 nucleotides, small, noncoding molecules involved in the regulation of gene expression. MiRNAs have a role in various immunological processes, including inflammation and fibrosis. Particularly, microRNA-21-5p (miR-21) is reported to be strongly associated with pathogenesis regarding tubulointerstitium. The aim of this study was to analyse expression levels of urinary miR-21 in the renal transplant recipients and evaluate their application in the assessment of IFTA and kidney allograft function. Method The expression levels of urinary miR-21 were measured in 31 renal transplant recipients with biopsy-evaluated IFTA (IFTA 0+I: n=17; IFTA II+III: n=14) by quantitative PCR. Protocolar biopsies were performed 1 or 2 years after renal transplantation. Urine samples were collected at the time of biopsy procedure. MicroRNA-191-5p was used as reference gene. Correlations between the clinicopathological parameters and the level of expression of miR-21 were assessed. Results Relative expression level of miR-21 was significantly increased in IFTA II+III group compared to IFTA 0+I group. MiR-21 correlated positively with serum concentration of creatinine and negatively with eGFR. ROC analysis showed diagnostic value of miR-21 with an area under curve (AUC) of 0.80, high sensitivity and specificity. Conclusion MiR-21 is associated with IFTA and dysfunction of kidney allograft. It may be considered as potential non-invasive biomarker of renal allograft function.

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