scholarly journals Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months

2009 ◽  
Vol 24 (8) ◽  
pp. 2567-2575 ◽  
Author(s):  
Andreas Scherer ◽  
Wilfried Gwinner ◽  
Michael Mengel ◽  
Torsten Kirsch ◽  
Friedrich Raulf ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies

scholarly journals Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Yishu Wang ◽  
Lei Pang ◽  
Yanghe Zhang ◽  
Jiahui Lin ◽  
Honglan Zhou
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Renal Allograft ◽  
Epithelial Mesenchymal Transition ◽  
Interstitial Fibrosis ◽  
Peroxisome Proliferator ◽  
Tubular Atrophy ◽  
Peroxisome Proliferator Activated Receptor ◽  
Mesenchymal Transition ◽  
Stage Renal Disease

The best treatment for end-stage renal disease is renal transplantation. However, it is often difficult to maintain a renal allograft healthy for a long time following transplantation. Interstitial fibrosis and tubular atrophy (IF/TA) are significant histopathologic characteristics of a compromised renal allograft. There is no effective therapy to improve renal allograft function once IF/TA sets in. Although there are many underlying factors that can induce IF/TA, the pathogenesis of IF/TA has not been fully elucidated. It has been found that epithelial-mesenchymal transition (EMT) significantly contributes to the development of IF/TA. Oxidative stress is one of the main causes that induce EMT in renal allografts. In this study, we have used H2O2 to induce oxidative stress in renal tubular epithelial cells (NRK-52e) of rats. We also pretreated NRK-52e cells with an antioxidant (N-acetyl L-cysteine (NAC)) 1 h prior to the treatment with H2O2. Furthermore, we used fenofibrate (a peroxisome proliferator-activated receptor α agonist) to treat NRK-52e cells and a renal transplant rat model. Our results reveal that oxidative stress induces EMT in NRK-52e cells, and pretreatment with NAC can suppress EMT in these cells. Moreover, fenofibrate suppresses fibrosis by ameliorating oxidative stress-induced EMT in a rat model. Thus, fenofibrate may effectively prevent the development of fibrosis in renal allograft and improve the outcome.

Intragraft Tubular Vimentin and CD44 Expression Correlate With Long-Term Renal Allograft Function and Interstitial Fibrosis and Tubular Atrophy

2010 ◽  
Vol 90 (5) ◽  
pp. 502-509 ◽  
Author(s):  
Jesper Kers ◽  
Yi-Chun Xu-Dubois ◽  
Eric Rondeau ◽  
Nike Claessen ◽  
Mirza M. Idu ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Cd44 Expression ◽  
Allograft Function

scholarly journals Intragraft Expression of the IL-10 Gene Is Up-Regulated in Renal Protocol Biopsies with Early Interstitial Fibrosis, Tubular Atrophy, and Subclinical Rejection

2010 ◽  
Vol 176 (4) ◽  
pp. 1696-1704 ◽  
Author(s):  
Miguel Hueso ◽  
Estanis Navarro ◽  
Francesc Moreso ◽  
Francisco O'Valle ◽  
Mercè Pérez-Riba ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies ◽  
Subclinical Rejection

Expression of pro- and antifibrotic genes in protocol biopsies from renal allografts with interstitial fibrosis and tubular atrophy

2008 ◽  
Vol 69 (06) ◽  
pp. 408-416 ◽  
Author(s):  
M. Mengel ◽  
O. Bock ◽  
M. Priess ◽  
H. Haller ◽  
H. Kreipe ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Renal Allografts ◽  
Protocol Biopsies

scholarly journals Renal Allograft Dysfunction Possibly Caused by Amiodarone Nephrotoxicity: a Case-Report

2017 ◽  
Vol 15 (1) ◽  
pp. 39-40
Author(s):  
Nikolina Basic-Jukic ◽  
Lea Katalinic ◽  
Marijana Coric ◽  
Monika Kocman ◽  
Branimir Krtalic ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Potent Inhibitor ◽  
Interstitial Fibrosis ◽  
Deceased Donor ◽  
Immunosuppressive Drugs ◽  
Tubular Atrophy ◽  
Careful Revision ◽  
Global Glomerulosclerosis ◽  
Trough Levels ◽  
Important Drug

AbstractAmiodarone is a potent inhibitor of CYP3A4 and can increase serum concentrations of drugs that are substrates of this enzyme system. Immunosuppressive drugs are also metabolized through the cytochrome metabolic pathway what may lead to important drug-drug interactions. A 60-year-old female received her second allograft from the deceased donor and was treated with tacrolimus, mycophenolate mofetil and steroids. Amiodarone was introduced for treatment of paroxysmal atrial fibrillation four days after the transplantation. One month after the discharge she was readmitted to hospital for evaluation of the creeping creatinine. Biopsy showed borderline acute rejection. She received 3 boluses of 6- methilprednisolone but creatinine continued to rise. Repeated biopsy was without signs of rejection with mild interstitial fibrosis/tubular atrophy, mild global glomerulosclerosis and moderate arterial sclerosis. However, tubular vacuolization was prominent. After careful revision of her therapy we decided to replace amiodarone with sotalol. One week later her creatinine fell from 350 to 220 μmol/l and remained stable. This case illustrates possible amiodarone nephrotoxicity in a renal transplant recipient. We suggest that patients who need amiodarone in combination with tacrolimus be closely monitored by both cardiologists and nephrologists, with frequent determinations of tacrolimus trough levels and serum creatinine measurements.

Comparison of Ultrasound Corticomedullary Strain with Doppler Parameters in Assessment of Renal Allograft Interstitial Fibrosis/Tubular Atrophy

2015 ◽  
Vol 41 (10) ◽  
pp. 2631-2639 ◽  
Author(s):  
Jing Gao ◽  
Jonathan M. Rubin ◽  
William Weitzel ◽  
Jun Lee ◽  
Darshana Dadhania ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy

URINARY CELL mRNA PROFILES ACCURATELY PREDICT RENAL ALLOGRAFT INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 13
Author(s):  
T Muthukumar ◽  
R Wanchoo ◽  
D Dadhania ◽  
R Ding ◽  
C Snopkowski ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy
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