Interstitial Fibrosis and Tubular Atrophy on Protocol Biopsies at 1 Year After Renal Transplantation

2012 ◽  
Vol 44 (3) ◽  
pp. 607-609 ◽  
Author(s):  
T. Yokoyama ◽  
O. Konno ◽  
Y. Nakamura ◽  
Y. Kihara ◽  
Y. Jojima ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies

scholarly journals Intragraft Expression of the IL-10 Gene Is Up-Regulated in Renal Protocol Biopsies with Early Interstitial Fibrosis, Tubular Atrophy, and Subclinical Rejection

2010 ◽  
Vol 176 (4) ◽  
pp. 1696-1704 ◽  
Author(s):  
Miguel Hueso ◽  
Estanis Navarro ◽  
Francesc Moreso ◽  
Francisco O'Valle ◽  
Mercè Pérez-Riba ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies ◽  
Subclinical Rejection

Expression of pro- and antifibrotic genes in protocol biopsies from renal allografts with interstitial fibrosis and tubular atrophy

2008 ◽  
Vol 69 (06) ◽  
pp. 408-416 ◽  
Author(s):  
M. Mengel ◽  
O. Bock ◽  
M. Priess ◽  
H. Haller ◽  
H. Kreipe ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Renal Allografts ◽  
Protocol Biopsies

Kidney Transplantation 2: Care of the Kidney Transplant Recipient

2017 ◽  
Author(s):  
Jamil Azzi ◽  
Belinda T. Lee ◽  
Anil Chandraker ◽  
Martina M McGrath
Keyword(s):  
Renal Transplantation ◽  
Interstitial Fibrosis ◽  
Kidney Transplant Recipient ◽  
Immune Monitoring ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Tubular Atrophy ◽  
Active Monitoring ◽  
Risk Factor Management ◽  
Management Of Complications

Renal transplantation is the preferred therapy for patients with end-stage kidney disease, leading to increased life expectancy, improved quality of life, and reduced health care resource use. Owing to their preexisting burden of disease, caring for renal transplant recipients is complex. Patient management following successful renal transplantation involves a multifactorial approach to cardiovascular risk factor management, along with titration of immunosuppression, management of complications related to immunosuppression, and active monitoring of allograft function. Recent advances in immunosuppressive management hold promise for improved long-term allograft survival. Finally, immune monitoring of transplant recipients is an area of considerable research, with the ultimate aim of individualized management of immunosuppression and the ability to induce transplant-specific tolerance. This review contains 7 figures,7 tables, and 117 references. Key words: cardiovascular disease, drug interactions, immunosuppression, infection, interstitial fibrosis and tubular atrophy, malignancy, rejection, tolerance

PROGRESSION OF INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY IN THE FIRST YEAR AFTER RENAL TRANSPLANTATION: EARLY PROGRESSION ESPECIALLY IN NON-HEART BEATING KIDNEYS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 60
Author(s):  
M H.L. Christiaans ◽  
M A.C.J. Gelens ◽  
F M.E.G. Steegh ◽  
J P. van Hooff ◽  
R J. van Suylen ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Interstitial Fibrosis ◽  
First Year ◽  
Tubular Atrophy ◽  
Heart Beating ◽  
Early Progression

scholarly journals P1741TACROLIMUS FAST METABOLIZERS SHOW A HIGHER PROGRESSION OF INTERTITIAL FIBROSIS AND TUBULAR ATROPHY DURING THE FIRST YEAR AFTER RENAL TRASPLANTATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Betty Chamoun Huacon ◽  
Irina Torres ◽  
Alejandra Gabaldon ◽  
Néstor Toapanta ◽  
Joana Sellares ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Univariate Analysis ◽  
First Year ◽  
Prolonged Release ◽  
Dose Ratio ◽  
Tubular Atrophy ◽  
Protocol Biopsies ◽  
The Difference ◽  
Independent Association ◽  
Allograft Loss

Abstract Background and Aims Fast tacrolimus metabolizers (expressed as the blood concentration/ dose ratio; C / D; ng / mL * mg) showed poorer renal function at 2 years, a higher incidence of nephrotoxicity and BK polyomavirus infection. Greater variability of tacrolimus trough levels (CV) from six to twelve months is associated with the appearance of HLA antibodies, interstitial fibrosis / tubular atrophy (IFTA) progression and allograft loss. We evaluate the relationship between C / D, CV and IFTA progression. Method We evaluated a cohort of 87 low immunological risk renal transplants treated with prolonged-release tacrolimus, mycophenolate mofetil and steroids. We analyzed paired protocol biopsies at 4 and 18 months. Biopsies were evaluated according to the Banff classification and the progression of IFTA was defined as the difference of ci + ct score> 0 between 18 and 4 months. The C / D ratio was calculated as the average of the value recorded at 3, 6 and 12 months of follow-up. The tacrolimus CV between 6 and 12 months was calculated using all the available determinations. Results IFTA progression was observed in 36 cases (41%). In the univariate analysis, it was found that the progression of IFTA was associated with the ci + ct score at 4 months (0.92 ± 0.94 for progressors vs. 1.89 ± 1.26 not progressors, p = 0.0003), and with the average of the C / D ratio (1.70 ± 0.73 for progressors vs. 2.28 ± 1.25 not progressors; p = 0.0144, table 1). An independent association between the C/D ratio and the progression of IFTA was observed in the multivariate analysis (OR: 0.42; 95% CI: 0.22-0.82, p = 0.027). Conclusion The results of our work suggest that fast tacrolimus metabolizers (lower C / D ratio) are more susceptible to the nephrotoxic effect of tacrolimus.

scholarly journals Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months

2009 ◽  
Vol 24 (8) ◽  
pp. 2567-2575 ◽  
Author(s):  
Andreas Scherer ◽  
Wilfried Gwinner ◽  
Michael Mengel ◽  
Torsten Kirsch ◽  
Friedrich Raulf ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Protocol Biopsies

Tubular Atrophy and Interstitial Fibrosis After Renal Transplantation Is Dependent on Galectin-3

2012 ◽  
Vol 93 (5) ◽  
pp. 477-484 ◽  
Author(s):  
Zexu Dang ◽  
Alison MacKinnon ◽  
Lorna P. Marson ◽  
Tariq Sethi
Keyword(s):  
Renal Transplantation ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Galectin 3

scholarly journals Sterile Leukocyturia Is Associated With Interstitial Fibrosis and Tubular Atrophy in Kidney Allograft Protocol Biopsies

2014 ◽  
Vol 14 (4) ◽  
pp. 908-915 ◽  
Author(s):  
S. Coelho ◽  
F. Ortíz ◽  
R. Gelpi ◽  
P. Koskinen ◽  
N. Porta ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Kidney Allograft ◽  
Protocol Biopsies
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