A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient

2017 ◽  
Vol 58 (4) ◽  
pp. e232-e235 ◽  
Author(s):  
Nishant Valecha ◽  
Genevieve Bennett ◽  
Leona Yip
Keyword(s):  
Erythema Nodosum ◽  
Nondiabetic Patient ◽  
Necrobiosis Lipoidica ◽  
Cutaneous Sarcoidosis

scholarly journals Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study

Dermatology ◽  
2018 ◽  
Vol 235 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Florian Anzengruber ◽  
Caroline Mergenthaler ◽  
Carla Murer ◽  
Reinhard Dummer
Keyword(s):  
Potassium Iodide ◽  
Erythema Nodosum ◽  
Therapy Response ◽  
University Hospital ◽  
Cutaneous Sarcoidosis ◽  
Study Results ◽  
Perioral Dermatitis ◽  
Progression Of Disease ◽  
Skin Conditions ◽  
Nodular Vasculitis

Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Methods: The hospital information system was searched for patients treated with KI at the Department of Dermatology (University Hospital Zurich) in the last 20 years (January 1, 1998 to December 31, 2017). A total of 52 patients were found and, subsequently, 35 patients were included in our study. Results: KI was prescribed for the following skin conditions: erythema nodosum, disseminated granuloma anulare, necrobiosis lipoidica, nodular vasculitis, cutaneous sarcoidosis, and granulomatous perioral dermatitis/ rosacea. The median duration of KI intake was 5 ± 7.7 weeks (range 1–26). The global assessment of efficacy by the treating physician showed an improvement of disease in about a third of all patients. No response was seen in 14 patients and 9 even had a progression of disease. An adverse event was documented in 16 cases. Conclusions: Our findings show that an improvement was reached in only about a third of all cases. High response rates with only mild side effects (in 16 out of 35 patients) were observed.

Necrobiosis Lipoidica Mimicking Cutaneous Sarcoidosis Finally Treated With an Intralesional Injection of Corticosteroid: A Case Report

2019 ◽  
Vol 19 (1) ◽  
pp. 92-94
Author(s):  
Mohamad Goldust ◽  
Ghasem Rahmatpour Rokni ◽  
Jeffrey Weinberg ◽  
Leon Kircik ◽  
Martine Bagot ◽  
...  
Keyword(s):  
Case Report ◽  
Intralesional Injection ◽  
Necrobiosis Lipoidica ◽  
Cutaneous Sarcoidosis

scholarly journals Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound

2016 ◽  
Vol 107 (6) ◽  
pp. 525-527
Author(s):  
J. García-Gavín ◽  
L. Comba Pérez-Pérez ◽  
L. Requena ◽  
X. Wortsman
Keyword(s):  
Nondiabetic Patient ◽  
Necrobiosis Lipoidica ◽  
Skin Ultrasound

scholarly journals Unusual presentation and successful treatment of necrobiosis lipoidica in a 15-year-old girl

2019 ◽  
Vol 3 (3) ◽  
pp. 219-222
Author(s):  
Allison L Limmer ◽  
Levi C Holland ◽  
Annabelle L Garcia
Keyword(s):  
Glucose Intolerance ◽  
Granulomatous Inflammation ◽  
Giant Cells ◽  
Diabetic Patients ◽  
Thyroid Disorder ◽  
Necrobiosis Lipoidica ◽  
Clinical Context ◽  
Cutaneous Sarcoidosis ◽  
Topical Tacrolimus ◽  
The Right

Necrobiosis lipoidica (NL) is a rare, granulomatous skin disease with a predilection for diabetic patients. NL can present both histopathologically and clinically in a similar fashion to other granulomatous dermatoses such as granuloma annulare, necrobiotic xanthogranuloma, and cutaneous sarcoidosis. When NL is suspected in patients without glucose intolerance, affirmative diagnosis can be difficult, and other comorbidities may be probed, as NL has been associated with conditions such as hypertension, dyslipidemia, and thyroid disorders. Familial disease has also been reported.In the following case report, we discuss a 15-year-old girl who presented with a new, single, pink atrophic plaque of the right pretibial region. Biopsy showed palisaded granulomatous inflammation within the dermis, absent dermal mucin, and rare multinucleated giant cells. This histopathologic description combined with the clinical context led to the diagnosis of necrobiosis lipoidica. The patient developed another similar lesion on the left anterior shin over the next 1.5 years which was also approached as necrobiosis lipoidica. The lesions were treated with intralesional triamcinolone acetonide and topical tacrolimus. Both lesions are now resolved with only mild atrophy of the affected areas. To date, the patient’s labs have shown no evidence of glucose intolerance, hyperlipidemia, or thyroid disorder.

scholarly journals Manifestations of Besnier-Boeck-Schaumann sarcoidosis on skin

2020 ◽  
pp. 83-86
Author(s):  
V. G. Akimov
Keyword(s):  
Differential Diagnosis ◽  
Erythema Nodosum ◽  
Diagnosis And Treatment ◽  
Unknown Etiology ◽  
Cutaneous Sarcoidosis ◽  
Clinical Forms ◽  
Lupus Pernio ◽  
Multisystemic Disease ◽  
Nodular Sarcoidosis ◽  
Systemic Sarcoidosis

Besnier-Boeck-Schaumann sarcoidosis is a multisystemic disease of unknown etiology. Only about 25 % of patients have cutaneous involvement. Every patient with cutaneous sarcoidosis should be evaluated for possible systemic sarcoidosis. This article contains descriptions and original images of clinical forms of the disease: miliary sarcoidosis, circinate sarcoidosis, nodular sarcoidosis, angiolupoid (Brocq-Potrier), lupus pernio (Besnier-Tennesson), erythema nodosum, subcutaneous sarcoidosis (Darier-Roussy). Differential diagnosis and treatment of patients are discussed.

scholarly journals Necrobiosis lipoidica‐like lesions in a nondiabetic patient with systemic sarcoidosis: A case report and review of the literature

2020 ◽  
Vol 8 (12) ◽  
pp. 2782-2786
Author(s):  
Farnaz Araghi ◽  
Mohammadreza Tabary ◽  
Azadeh Rakhshan ◽  
Sahar Dadkhahfar ◽  
Reza M. Robati
Keyword(s):  
Case Report ◽  
Nondiabetic Patient ◽  
Necrobiosis Lipoidica ◽  
Review Of The Literature ◽  
Systemic Sarcoidosis

scholarly journals Cutaneous Sarcoidosis Clinically Mimicking Necrobiosis Lipoidica in a Patient with Systemic Sarcoidosis

2012 ◽  
Vol 24 (1) ◽  
pp. 74 ◽  
Author(s):  
Takahito Chiba ◽  
Masakazu Takahara ◽  
Takeshi Nakahara ◽  
Shuji Fukagawa ◽  
Kenjiro Takei ◽  
...  
Keyword(s):  
Necrobiosis Lipoidica ◽  
Cutaneous Sarcoidosis ◽  
Systemic Sarcoidosis

Granulomatous panniculitis in erythema nodosum

1975 ◽  
Vol 111 (3) ◽  
pp. 335-340 ◽  
Author(s):  
L. Forstrom
Keyword(s):  
Erythema Nodosum
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