scholarly journals The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning

2013 ◽  
Vol 19 (1) ◽  
pp. 87-101 ◽  
Author(s):  
Lori A. Knackstedt ◽  
Heather L. Trantham-Davidson ◽  
Marek Schwendt
Keyword(s):  
Dorsal Striatum ◽  
Extinction Learning ◽  
Cocaine Seeking

scholarly journals mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Lori A. Knackstedt ◽  
Marek Schwendt
Keyword(s):  
Relapse Prevention ◽  
Operant Chamber ◽  
Treatment Strategies ◽  
Surface Expression ◽  
Self Administration ◽  
Extinction Learning ◽  
Learning Deficits ◽  
Cocaine Seeking ◽  
Mglu5 Receptors

We have previously demonstrated that MTEP, an allosteric antagonist of mGlu5, infused into the nucleus accumbens attenuates relapse after abstinence from cocaine self-administration. MTEP infused into the dorsolateral striatum (dlSTR) does not alter relapse but has long-lasting effects on subsequent extinction learning. Here we tested whether systemic MTEP would prevent relapse after abstinence or alter extinction learning. We also investigated the mechanism of action by which intra-dlSTR MTEP on test day alters extinction on subsequent days. Animals self-administered cocaine for 12 days followed by abstinence for 20-21 days. MTEP (0.5–5 mg/kg IP) was administered prior to placement into the operant chamber for a context-primed relapse test. A separate group of animals received intra-dlSTR MTEP prior to the relapse test and were sacrificed day later. Systemic administration of MTEP attenuated abstinent-relapse without significantly affecting extinction learning. Surface biotinylation analysis of protein expression in the dlSTR revealed that, in cocaine animals, intra-dlSTR MTEP administration decreased mGlu5 surface expression and prevented changes in Arc and GluA1/GluA2 observed in their vehicle counterparts. Thus, blockade of mGlu5 receptors may be utilized in future treatment strategies for relapse prevention in humans, although the effects of chronic blockade on extinction learning should be further evaluated.

scholarly journals Conditional Control of Instrumental Avoidance by Context Following Extinction

2021 ◽  
Vol 15 ◽  
Author(s):  
Vincent D. Campese ◽  
Lauren A. Brannigan ◽  
Joseph E. LeDoux
Keyword(s):  
Hierarchical Control ◽  
Response Rates ◽  
Training Context ◽  
Extinction Learning ◽  
Retention Testing ◽  
Conditional Control ◽  
Within Subjects ◽  
Pavlovian Extinction ◽  
Contrast Response

Using rodents, three training arrangements (i.e., ABB vs. ABA, AAA vs. AAB and ABB vs. ABC) explored whether extinction influences the expression of avoidance in a manner controlled by context. Retention testing following extinction showed that more avoidance responding (i.e., renewal) was observed when extinguished cues were tested outside of the context where they had undergone extinction. In contrast, response rates were significantly lower when stimuli were tested within the context where extinction learning had occurred. These findings add to the emerging literature assessing the role of Pavlovian extinction processes in the development of instrumental avoidance responding by demonstrating conditional control over extinguished responding by context. This study was conducted using a within-subjects approach that minimized the potential for context-outcome associations to bias responding, and thus, reflects hierarchical control over behavior based on the specific associative status of each tested cue in each training context.

Utilizing the Cortico-Striatal Projectome to Advance the Study of Timing and Time Perception

2016 ◽  
Vol 4 (4) ◽  
pp. 411-422 ◽  
Author(s):  
Nicholas A. Lusk ◽  
Dean V. Buonomano
Keyword(s):  
Time Perception ◽  
Temporal Processing ◽  
Large Scale ◽  
Imaging Techniques ◽  
Brain Connectivity ◽  
Beat Frequency ◽  
Dorsal Striatum ◽  
Frequency Model ◽  
Timing And Time Perception

Over the past decade advances in tracing and imaging techniques have spurred the development of increasingly detailed maps of brain connectivity. Broadly termed ‘connectomes’, these maps provide a powerful tool for systems neuroscience. As with most ‘maps’, connectomes offer a static spatial description of the brain’s circuits, whereas timing and temporal processing are inherently dynamic processes; nevertheless, the timing field stands to be a major beneficiary of these large-scale mapping projects. The recently reported ‘projectome’ of mouse cortico-striatal sub-networks is of particular interest because theoretical developments such as the striatal beat-frequency model emphasize the role of the striatum in temporal processing. The cortico-striatal projectome confirms that the dorsal striatum is ideally situated to sample patterns of activity throughout most of the cortex, but that it also contains a level of modularity previously not considered by integrative models of interval timing. Furthermore, the striatal projectome will allow for targeted studies of whether specific subdivisions of the dorsal striatum are differentially involved in timing and time perception as a function of task, stimulus modality, intensity, and valence.

scholarly journals Maternal Diet Influences the Reinstatement of Cocaine-Seeking Behavior and the Expression of Melanocortin-4 Receptors in Female Offspring of Rats

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1462
Author(s):  
Dawid Gawliński ◽  
Kinga Gawlińska ◽  
Małgorzata Frankowska ◽  
Małgorzata Filip
Keyword(s):  
Maternal Diet ◽  
Dorsal Striatum ◽  
Brain Structures ◽  
Female Offspring ◽  
Self Administration ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Pregnancy And Lactation ◽  
The Impact ◽  
Cocaine Reward

Recent studies have emphasized the role of the maternal diet in the development of mental disorders in offspring. Substance use disorder is a major global health and economic burden. Therefore, the search for predisposing factors for the development of this disease can contribute to reducing the health and social damage associated with addiction. In this study, we focused on the impact of the maternal diet on changes in melanocortin-4 (MC-4) receptors as well as on behavioral changes related to cocaine addiction. Rat dams consumed a high-fat diet (HFD), high-sugar diet (HSD, rich in sucrose), or mixed diet (MD) during pregnancy and lactation. Using an intravenous cocaine self-administration model, the susceptibility of female offspring to cocaine reward and cocaine-seeking propensities was evaluated. In addition, the level of MC-4 receptors in the rat brain structures related to cocaine reward and relapse was assessed. Modified maternal diets did not affect cocaine self-administration in offspring. However, the maternal HSD enhanced cocaine-seeking behavior in female offspring. In addition, we observed that the maternal HSD and MD led to increased expression of MC-4 receptors in the nucleus accumbens, while increased MC-4 receptor levels in the dorsal striatum were observed after exposure to the maternal HSD and HFD. Taken together, it can be concluded that a maternal HSD is an important factor that triggers cocaine-seeking behavior in female offspring and the expression of MC-4 receptors.

64 OVER EXPRESSION OF THE SCHIZOPHRENIA-ASSOCIATED RISK GENE MIR-137 IN THE DORSAL STRIATUM PROMOTES COMPULSIVE COCAINE-SEEKING

2019 ◽  
Vol 29 ◽  
pp. S95-S96
Author(s):  
Laura Greco ◽  
Simon D. Fisher ◽  
Amy Pearl ◽  
Leila Akbari ◽  
Michael Geaghan ◽  
...  
Keyword(s):  
Dorsal Striatum ◽  
Over Expression ◽  
Risk Gene ◽  
Cocaine Seeking

scholarly journals Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue‐induced cocaine seeking

2020 ◽  
Author(s):  
Allison R. Bechard ◽  
Carly N. Logan ◽  
Javier Mesa ◽  
Yasmin Padovan‐Hernandez ◽  
Harrison Blount ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Nucleus Accumbens Core ◽  
Cocaine Seeking ◽  
Accumbens Core

scholarly journals Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1018
Author(s):  
Caitlyn A. Mullins ◽  
Ritchel B. Gannaban ◽  
Md Shahjalal Khan ◽  
Harsh Shah ◽  
Md Abu B. Siddik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Homeostasis ◽  
Dorsal Striatum ◽  
Brain Regions ◽  
Therapeutic Interventions ◽  
Low Grade ◽  
Obesity Prevalence ◽  
Beneficial Effects ◽  
The Brain

Obesity prevalence is increasing at an unprecedented rate throughout the world, and is a strong risk factor for metabolic, cardiovascular, and neurological/neurodegenerative disorders. While low-grade systemic inflammation triggered primarily by adipose tissue dysfunction is closely linked to obesity, inflammation is also observed in the brain or the central nervous system (CNS). Considering that the hypothalamus, a classical homeostatic center, and other higher cortical areas (e.g. prefrontal cortex, dorsal striatum, hippocampus, etc.) also actively participate in regulating energy homeostasis by engaging in inhibitory control, reward calculation, and memory retrieval, understanding the role of CNS oxidative stress and inflammation in obesity and their underlying mechanisms would greatly help develop novel therapeutic interventions to correct obesity and related comorbidities. Here we review accumulating evidence for the association between ER stress and mitochondrial dysfunction, the main culprits responsible for oxidative stress and inflammation in various brain regions, and energy imbalance that leads to the development of obesity. Potential beneficial effects of natural antioxidant and anti-inflammatory compounds on CNS health and obesity are also discussed.

scholarly journals Role of Nucleus Accumbens Shell Neuronal Ensembles in Context-Induced Reinstatement of Cocaine-Seeking

2014 ◽  
Vol 34 (22) ◽  
pp. 7437-7446 ◽  
Author(s):  
F. C. Cruz ◽  
K. R. Babin ◽  
R. M. Leao ◽  
E. M. Goldart ◽  
J. M. Bossert ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nucleus Accumbens Shell ◽  
Neuronal Ensembles ◽  
Cocaine Seeking
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