scholarly journals Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cue‐induced cocaine seeking

2020 ◽  
Author(s):  
Allison R. Bechard ◽  
Carly N. Logan ◽  
Javier Mesa ◽  
Yasmin Padovan‐Hernandez ◽  
Harrison Blount ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Nucleus Accumbens Core ◽  
Cocaine Seeking ◽  
Accumbens Core

scholarly journals Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cued cocaine relapse

2020 ◽  
Author(s):  
Allison R. Bechard ◽  
Carly N. Logan ◽  
Javier Mesa ◽  
Yasmin Padovan Hernandez ◽  
Harrison Blount ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Basolateral Amygdala ◽  
Male Rats ◽  
Self Administration ◽  
Nucleus Accumbens Core ◽  
Cocaine Seeking ◽  
Context Cues ◽  
Glutamate Efflux

AbstractCeftriaxone is an antibiotic that reliably attenuates the reinstatement of cocaine-seeking after extinction while preventing the nucleus accumbens (NA) core glutamate efflux that drives reinstatement. However, when rats undergo abstinence without extinction, ceftriaxone attenuates context-primed relapse but NA core glutamate efflux still increases. Here we sought to determine if the same would occur when relapse is prompted by both context and discrete cues (context+cues) after cocaine abstinence. Male rats self-administered intravenous cocaine for 2 hr/day for 2 weeks. Cocaine delivery was accompanied by drug-associated cues (light+tone). Rats were then placed into abstinence with daily handling but no extinction training for two weeks. Ceftriaxone (200 mg/kg IP) or vehicle was administered during the last 6 days of abstinence. During a context+cue relapse test, microdialysis procedures were conducted. Rats were perfused at the end of the test for later Fos analysis. A separate cohort of rats was infused with the retrograde tracer cholera toxin B in the NA core and underwent the same self-administration and relapse procedures. Ceftriaxone increased baseline glutamate and attenuated both context+cue-primed relapse and NA core glutamate efflux during this test. Ceftriaxone reduced Fos expression in regions sending projections to the NA core (prefrontal cortex, basolateral amygdala, ventral tegmental area) and specifically reduced Fos in prelimbic cortex and not infralimbic cortex neurons projecting to the NA core. Thus, when relapse is primed by drug-associated cues and context, ceftriaxone is able to attenuate relapse by preventing NA core glutamate efflux, likely through reducing activity in prelimbic NA core-projecting neurons.

scholarly journals AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xue-Jiao Gao ◽  
Kai Yuan ◽  
Lu Cao ◽  
Wei Yan ◽  
Yi-Xiao Luo ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nucleus Accumbens Core ◽  
Ampk Signaling ◽  
Cocaine Seeking ◽  
Accumbens Core

scholarly journals A Shift in the Role of Glutamatergic Signaling in the Nucleus Accumbens Core With the Development of an Addicted Phenotype

2014 ◽  
Vol 76 (10) ◽  
pp. 810-815 ◽  
Author(s):  
Susan E. Doyle ◽  
Carolina Ramôa ◽  
Garrett Garber ◽  
Joshua Newman ◽  
Zeeshan Toor ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nucleus Accumbens Core ◽  
Glutamatergic Signaling ◽  
Accumbens Core

scholarly journals Role of the medial prefrontal cortex and nucleus accumbens in an operant model of checking behaviour and uncertainty

2017 ◽  
Vol 1 ◽  
pp. 239821281773340 ◽  
Author(s):  
Camilla d’Angelo ◽  
Dawn M. Eagle ◽  
Cristina-M. Coman ◽  
Trevor W. Robbins
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Obsessive Compulsive Disorder ◽  
Medial Prefrontal Cortex ◽  
Nucleus Accumbens Core ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Observing Response ◽  
Response Task ◽  
Accumbens Core

Background: Excessive checking is a common, debilitating symptom of obsessive–compulsive disorder. To further examine cognitive processes underpinning checking behaviour, and clarify how and why checking develops, we designed a novel operant paradigm for rats, the observing response task. The present study used the observing response task to investigate checking behaviour following excitotoxic lesions of the medial prefrontal cortex, nucleus accumbens core and dorsal striatum, brain regions considered to be of relevance to obsessive–compulsive disorder. Methods: In the observing response task, rats pressed an ‘observing’ lever for information (provided by light onset) about the location of an ‘active’ lever that provided food reinforcement. Following training, rats received excitotoxic lesions of the regions described above and performance was evaluated post-operatively before histological processing. Results: Medial prefrontal cortex lesions selectively increased functional checking with a less-prominent effect on non-functional checking and reduced discrimination accuracy during light information periods. Rats with nucleus accumbens core lesions made significantly more checking responses than sham-lesioned rats, including both functional and non-functional checking. Dorsal striatum lesions had no direct effect on checking per se, but reduced both active and inactive lever presses, and therefore changed the relative balance between checking responses and instrumental responses. Conclusions: These results suggest that the medial prefrontal cortex and nucleus accumbens core are important in the control of checking, perhaps via their role in processing uncertainty of reinforcement, and that dysfunction of these regions may therefore promote excessive checking behaviour, possibly relevant to obsessive-compulsive disorder.

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