scholarly journals Exploration of multi‐target effects of 3‐benzoyl‐5‐hydroxychromen‐2‐one in Alzheimer’s disease cell and mouse models

Aging Cell ◽  
2020 ◽  
Vol 19 (7) ◽  
Author(s):  
Te‐Hsien Lin ◽  
Ya‐Jen Chiu ◽  
Chih‐Hsin Lin ◽  
Chung‐Yin Lin ◽  
Chih‐Ying Chao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Disease Cell ◽  
Target Effects

Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer’s Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement

2019 ◽  
Vol 67 (2) ◽  
pp. 737-756 ◽  
Author(s):  
Yi-Chun Chen ◽  
Ya-Jen Chiu ◽  
Chih-Hsin Lin ◽  
Wen-Chuin Hsu ◽  
Jia-Lu Wu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Indole Compound ◽  
Cognitive Improvement ◽  
Disease Cell

Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease

2013 ◽  
Vol 106 ◽  
pp. 57-67 ◽  
Author(s):  
Chun-Ming Wang ◽  
Ming-Yan Liu ◽  
Fang Wang ◽  
Min-Jie Wei ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amnesic Effect

scholarly journals Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease

2010 ◽  
Vol 21 (3) ◽  
pp. 321-329 ◽  
Author(s):  
Zareen Amtul ◽  
David Westaway ◽  
David F. Cechetto ◽  
Richard F. Rozmahel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oleic Acid ◽  
Mouse Models

Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair

2021 ◽  
Vol 18 ◽  
Author(s):  
Nazanin Mirzaei ◽  
Nicola Davis ◽  
Tsz Wing Chau ◽  
Magdalena Sastre
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Mouse Models ◽  
Neurodegenerative Disorders ◽  
Amyloid Β ◽  
Neuroprotective Effects ◽  
Synaptic Density ◽  
Inflammatory Profile

: Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly in Alzheimer’s disease (AD), with the prominent presence of reactive astrocytes sur- rounding amyloid β- plaques, together with activated microglia. Reactive astrogliosis, implying morphological and molecular transformations in astrocytes, seems to precede neurodegeneration, suggesting a role in the development of the disease. Single-cell transcriptomics has recently demon- strated that astrocytes from AD brains are different from “normal” healthy astrocytes, showing dys- regulations in areas such as neurotransmitter recycling, including glutamate and GABA, and im- paired homeostatic functions. However, recent data suggest that the ablation of astrocytes in mouse models of amyloidosis results in an increase in amyloid pathology as well as in the inflammatory profile and reduced synaptic density, indicating that astrocytes mediate neuroprotective effects. The idea that interventions targeting astrocytes may have great potential for AD has therefore emerged, supported by a range of drugs and stem cell transplantation studies that have successfully shown a therapeutic effect in mouse models of AD. In this article, we review the latest reports on the role and profile of astrocytes in AD brains and how manipulation of astrocytes in animal mod- els has paved the way for the use of treatments enhancing astrocytic function as future therapeutic avenues for AD.

scholarly journals Contributions of a high-fat diet to Alzheimer's disease-related decline: A longitudinal behavioural and structural neuroimaging study in mouse models

2019 ◽  
Vol 21 ◽  
pp. 101606 ◽  
Author(s):  
Colleen P.E. Rollins ◽  
Daniel Gallino ◽  
Vincent Kong ◽  
Gülebru Ayranci ◽  
Gabriel A. Devenyi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
High Fat Diet ◽  
High Fat ◽  
Structural Neuroimaging ◽  
Neuroimaging Study

scholarly journals Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

2018 ◽  
Vol 527 (13) ◽  
pp. 2122-2145 ◽  
Author(s):  
Jennifer D. Whitesell ◽  
Alex R. Buckley ◽  
Joseph E. Knox ◽  
Leonard Kuan ◽  
Nile Graddis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Imaging ◽  
Mouse Models ◽  
Spatial Patterns ◽  
Amyloid Beta ◽  
Whole Brain
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