Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer’s Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement

2019 ◽  
Vol 67 (2) ◽  
pp. 737-756 ◽  
Author(s):  
Yi-Chun Chen ◽  
Ya-Jen Chiu ◽  
Chih-Hsin Lin ◽  
Wen-Chuin Hsu ◽  
Jia-Lu Wu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Indole Compound ◽  
Cognitive Improvement ◽  
Disease Cell

scholarly journals Exploration of multi‐target effects of 3‐benzoyl‐5‐hydroxychromen‐2‐one in Alzheimer’s disease cell and mouse models

Aging Cell ◽  
2020 ◽  
Vol 19 (7) ◽  
Author(s):  
Te‐Hsien Lin ◽  
Ya‐Jen Chiu ◽  
Chih‐Hsin Lin ◽  
Chung‐Yin Lin ◽  
Chih‐Ying Chao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Disease Cell ◽  
Target Effects

Cognitive Improvement by Photic Stimulation in a Mouse Model of Alzheimer’s Disease

2015 ◽  
Vol 12 (9) ◽  
pp. 860-869 ◽  
Author(s):  
Yu Zhang ◽  
Furong Wang ◽  
Xianwen Luo ◽  
Li Wang ◽  
Peng Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Photic Stimulation ◽  
Cognitive Improvement ◽  
Model Of Alzheimer’S Disease

scholarly journals Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment

2021 ◽  
Vol 14 (3) ◽  
pp. 503-510 ◽  
Author(s):  
Xingxing Li ◽  
Gangqiao Qi ◽  
Chang Yu ◽  
Guomin Lian ◽  
Hong Zheng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cortical Plasticity ◽  
Cognitive Improvement

Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease

2013 ◽  
Vol 106 ◽  
pp. 57-67 ◽  
Author(s):  
Chun-Ming Wang ◽  
Ming-Yan Liu ◽  
Fang Wang ◽  
Min-Jie Wei ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amnesic Effect

scholarly journals Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna A. Lauer ◽  
Daniel Janitschke ◽  
Malena dos Santos Guilherme ◽  
Vu Thu Thuy Nguyen ◽  
Cornel M. Bachmann ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Amyloid Β ◽  
Lipid Homeostasis ◽  
Medical Surveillance ◽  
Shotgun Lipidomics ◽  
App Processing ◽  
Cognitive Improvement ◽  
The Impact

AbstractAlzheimer’s disease (AD) is a very frequent neurodegenerative disorder characterized by an accumulation of amyloid-β (Aβ). Acitretin, a retinoid-derivative and approved treatment for Psoriasis vulgaris, increases non-amyloidogenic Amyloid-Precursor-Protein-(APP)-processing, prevents Aβ-production and elicits cognitive improvement in AD mouse models. As an unintended side effect, acitretin could result in hyperlipidemia. Here, we analyzed the impact of acitretin on the lipidome in brain and liver tissue in the 5xFAD mouse-model. In line with literature, triglycerides were increased in liver accompanied by increased PCaa, plasmalogens and acyl-carnitines, whereas SM-species were decreased. In brain, these effects were partially enhanced or similar but also inverted. While for SM and plasmalogens similar effects were found, PCaa, TAG and acyl-carnitines showed an inverse effect in both tissues. Our findings emphasize, that potential pharmaceuticals to treat AD should be carefully monitored with respect to lipid-homeostasis because APP-processing itself modulates lipid-metabolism and medication might result in further and unexpected changes. Moreover, deducing effects of brain lipid-homeostasis from results obtained for other tissues should be considered cautiously. With respect to acitretin, the increase in brain plasmalogens might display a further positive probability in AD-treatment, while other results, such as decreased SM, indicate the need of medical surveillance for treated patients.

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