scholarly journals Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

2018 ◽  
Vol 527 (13) ◽  
pp. 2122-2145 ◽  
Author(s):  
Jennifer D. Whitesell ◽  
Alex R. Buckley ◽  
Joseph E. Knox ◽  
Leonard Kuan ◽  
Nile Graddis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Imaging ◽  
Mouse Models ◽  
Spatial Patterns ◽  
Amyloid Beta ◽  
Whole Brain

P4-225: WHOLE BRAIN IMAGING REVEALS DISTINCT SPATIAL PATTERNS OF AMYLOID BETA DEPOSITION AND ATROPHY IN MOUSE MODELS OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_29) ◽  
pp. P1528-P1529
Author(s):  
Jennifer D. Whitesell ◽  
Alex R. Buckley ◽  
Nile Graddis ◽  
Leonard Kuan ◽  
Joseph E. Knox ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Imaging ◽  
Mouse Models ◽  
Spatial Patterns ◽  
Amyloid Beta ◽  
Whole Brain

scholarly journals Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer’s disease

2018 ◽  
Author(s):  
Jennifer D. Whitesell ◽  
Alex R. Buckley ◽  
Joseph E. Knox ◽  
Leonard Kuan ◽  
Nile Graddis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Imaging ◽  
Mouse Models ◽  
Amyloid Β ◽  
Retrosplenial Cortex ◽  
Whole Brain ◽  
Mutant Forms ◽  
Tg2576 Mice

AbstractA variety of Alzheimer’s disease (AD) mouse models overexpress mutant forms of human amyloid precursor protein (APP), producing high levels of amyloid β (Aβ) and forming plaques However, the degree to which these models mimic spatiotemporal patterns of Aβ deposition in brains of AD patients is unknown. Here, we mapped the spatial distribution of Aβ plaques across ages in three APP-overexpression mouse lines (APP/PS1, Tg2576, hAPP-J20) using in vivo labeling with methoxy-X04, high throughput whole brain imaging, and an automated informatics pipeline. Images were acquired with high resolution serial 2-photon tomography and labeled plaques were detected using custom-built segmentation algorithms. Image series were registered to the Allen Mouse Brain Common Coordinate Framework, a 3D reference atlas, enabling automated brain-wide quantification of plaque density, number, and location. In both APP/PS1 and Tg2576 mice, plaques were identified first in isocortex, followed by olfactory, hippocampal, and cortical subplate areas. In hAPP-J20 mice, plaque density was highest in hippocampal areas, followed by isocortex, with little to no involvement of olfactory or cortical subplate areas. Within the major brain divisions, distinct regions were identified with high (or low) plaque accumulation; e.g., the lateral visual area within the isocortex of APP/PS1 mice had relatively higher plaque density compared with other cortical areas, while in hAPP-J20 mice, plaques were densest in the ventral retrosplenial cortex. In summary, we show how whole brain imaging of amyloid pathology in mice reveals the extent to which a given model recapitulates the regional Aβ deposition patterns described in AD.

Bexarotene cannot reduce amyloid beta plaques through inhibition of production of amyloid beta peptides:in silicoandin vitrostudy

2018 ◽  
Vol 20 (37) ◽  
pp. 24329-24338 ◽  
Author(s):  
Huy Dinh Quoc Pham ◽  
Nguyen Quoc Thai ◽  
Zuzana Bednarikova ◽  
Huynh Quang Linh ◽  
Zuzana Gazova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Beta ◽  
Therapeutic Potential ◽  
Cancer Drug ◽  
Anti Cancer

Recently, it has been reported that anti-cancer drug bexarotene can remarkably destroy amyloid beta (Aβ) plaques in mouse models suggesting therapeutic potential for Alzheimer's disease.

P-188: Memantine lowers amyloid beta levels in neuronal cells and transgenic mouse models of Alzheimer's disease

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S158-S158
Author(s):  
Pradeep Banerjee ◽  
Heikki Tanila ◽  
Thomas Wisniewski ◽  
Sandeep Gupta ◽  
Frank LaFerla ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Amyloid Beta ◽  
Neuronal Cells ◽  
Transgenic Mouse Models

scholarly journals Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Julien Dufort-Gervais ◽  
Chloé Provost ◽  
Laurence Charbonneau ◽  
Christopher M. Norris ◽  
Frédéric Calon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Beta

scholarly journals Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Dag Sehlin ◽  
Xiaotian T. Fang ◽  
Linda Cato ◽  
Gunnar Antoni ◽  
Lars Lannfelt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Beta ◽  
Pet Imaging
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