Kinetics of leukocyte CD11b and CD64 expression in severe sepsis and non-infectious critical care patients

2015 ◽  
Vol 59 (7) ◽  
pp. 881-891 ◽  
Author(s):  
J. Jämsä ◽  
V. Huotari ◽  
E.-R. Savolainen ◽  
H. Syrjälä ◽  
T. Ala-kokko
Keyword(s):  
Critical Care ◽  
Severe Sepsis ◽  
Cd64 Expression ◽  
Kinetics Of ◽  
Critical Care Patients

Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital

1987 ◽  
Vol 32 (3) ◽  
pp. 273-277 ◽  
Author(s):  
G. Heinemeyer ◽  
H. J. Gramm ◽  
W. Simgen ◽  
R. Dennhardt ◽  
I. Roots
Keyword(s):  
Critical Care ◽  
High Dose ◽  
Kinetics Of ◽  
Critical Care Patients

The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction

1993 ◽  
Vol 45 (5) ◽  
pp. 445-450 ◽  
Author(s):  
G. Heinemeyer ◽  
H. -J. Gramm ◽  
I. Roots ◽  
R. Dennhardt ◽  
W. Simgen
Keyword(s):  
Critical Care ◽  
Renal Dysfunction ◽  
Acute Renal Dysfunction ◽  
Kinetics Of ◽  
Critical Care Patients

Presepsin as a potential marker for bacterial infection relapse in critical care patients. A preliminary study

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Valeria Sargentini ◽  
Giancarlo Ceccarelli ◽  
Mariadomenica D’Alessandro ◽  
Daniela Collepardo ◽  
Andrea Morelli ◽  
...  
Keyword(s):  
Critical Care ◽  
Severe Sepsis ◽  
Bacterial Infection ◽  
Clinical Symptoms ◽  
Multiple Time ◽  
Roc Curve Analysis ◽  
Clinical Recurrence ◽  
Potential Marker ◽  
Significant Difference ◽  
Critical Care Patients

AbstractSystemic bacterial infection carries a high risk of mortality in critical care patients. Improvements in diagnostic procedures are required for effective management of sepsis. Recently, the soluble CD14 subtype, or presepsin, has been suggested as a reliable marker of sepsis, and we set out to compare its diagnostic performance with that of procalcitonin (PCT). We focused on a cohort of septic patients who, during their hospitalization, relapsed after a period of clinical relief from symptoms.In total 21 adult patients were studied during their hospitalization in the Critical Care Unit of Policlinico Umberto I hospital; 74 plasma samples were collected at multiple time points, and presepsin levels were measured using a PATHFASTPresepsin and PCT were significantly lower in healthy controls than in sepsis or severe sepsis (p<0.001), both enabled a significant difference to be detected between systemic inflammatory response syndrome (SIRS) and severe sepsis (p<0.05). The area under the curve (AUC) calculated from the receiver operating characteristic (ROC) curve analysis was 0.888 for presepsin and 0.910 for PCT. In those patients in whom a clinical recurrence of sepsis was observed, while PCT levels normalized during the transient remission phase, presepsin levels (>1000 pg/mL) remained high.This study confirms the importance of monitoring a combination of several biomarkers in order to obtain a reliable diagnosis. Maximal presepsin levels could alert clinicians not to suspend antibiotic treatments and to carefully monitor septic patients’ state of health, even after clinical symptoms have disappeared and PCT levels returned to normal.

Detection of sepsis in patient blood samples using CD64 expression in a microfluidic cell separation device

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 241-249 ◽  
Author(s):  
Ye Zhang ◽  
Wenjie Li ◽  
Yun Zhou ◽  
Amanda Johnson ◽  
Amanda Venable ◽  
...  
Keyword(s):  
Critical Care ◽  
Cell Separation ◽  
Affinity Separation ◽  
Separation Device ◽  
Blood Samples ◽  
Cd64 Expression ◽  
Critical Care Patients

A microfluidic affinity separation device was developed for the detection of sepsis in critical care patients.

scholarly journals The pathophysiology of “happy” hypoglycemia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Thomas Loeb ◽  
Anna Ozguler ◽  
Geraldine Baer ◽  
Michel Baer
Keyword(s):  
Critical Care ◽  
Hemorrhagic Shock ◽  
Lactate Production ◽  
Severe Hypoglycemia ◽  
Altered Mental Status ◽  
Case Presentation ◽  
Energy Substrate ◽  
Tissue Hypoperfusion ◽  
The Brain ◽  
Critical Care Patients

Abstract Background Hypoglycemia usually includes various neurological symptoms, which are the consequence of neuroglycopenia. When it is severe, it is associated with altered mental status, even coma. Case presentation We report the case of a patient with severe hypoglycemia, completely asymptomatic, due to the increase of lactate production in response to tissue hypoperfusion following a hemorrhagic shock. This illustrates that lactate can substitute glucose as an energy substrate for the brain. It is also a reminder that this metabolite, despite its bad reputation maintained by its role as a marker of severity in critical care patients, has a fundamental role in our metabolism. Conclusions Following the example of the “happy hypoxemia” recently reported in the literature describing asymptomatic hypoxemia in COVID-19 patients, we describe a case of “happy hypoglycemia.”

CD64 expression on monocytes and granulocytes in pediatric acute appendicitis scenario: A pilot study in pediatric critical care

2020 ◽  
Vol 44 (5) ◽  
pp. 315-317
Author(s):  
A. García-Salido ◽  
M. De Lucio-Rodríguez ◽  
J.L. Alonso Calderón ◽  
G. De Lama Caro-Patón ◽  
M. Ramírez-Orellana ◽  
...  
Keyword(s):  
Critical Care ◽  
Pilot Study ◽  
Acute Appendicitis ◽  
Pediatric Critical Care ◽  
Cd64 Expression

scholarly journals Improving glycemic control in critical care patients

2008 ◽  
Vol 3 (4) ◽  
pp. 30-35
Author(s):  
Julie L. Stone ◽  
Linda L. Hutchinson
Keyword(s):  
Critical Care ◽  
Glycemic Control ◽  
Critical Care Patients

Insulin infusion therapy in critical care patients: Regular insulin vs short-acting insulin. A prospective, crossover, randomized, multicenter blind study

2015 ◽  
Vol 30 (2) ◽  
pp. 437.e1-437.e6 ◽  
Author(s):  
Federico Bilotta ◽  
Rafael Badenes ◽  
Simona Lolli ◽  
Francisco Javier Belda ◽  
Sharon Einav ◽  
...  
Keyword(s):  
Critical Care ◽  
Insulin Infusion ◽  
Regular Insulin ◽  
Blind Study ◽  
Infusion Therapy ◽  
Short Acting ◽  
Acting Insulin ◽  
Short Acting Insulin ◽  
Critical Care Patients
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