Detection of sepsis in patient blood samples using CD64 expression in a microfluidic cell separation device

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 241-249 ◽  
Author(s):  
Ye Zhang ◽  
Wenjie Li ◽  
Yun Zhou ◽  
Amanda Johnson ◽  
Amanda Venable ◽  
...  
Keyword(s):  
Critical Care ◽  
Cell Separation ◽  
Affinity Separation ◽  
Separation Device ◽  
Blood Samples ◽  
Cd64 Expression ◽  
Critical Care Patients

A microfluidic affinity separation device was developed for the detection of sepsis in critical care patients.

Kinetics of leukocyte CD11b and CD64 expression in severe sepsis and non-infectious critical care patients

2015 ◽  
Vol 59 (7) ◽  
pp. 881-891 ◽  
Author(s):  
J. Jämsä ◽  
V. Huotari ◽  
E.-R. Savolainen ◽  
H. Syrjälä ◽  
T. Ala-kokko
Keyword(s):  
Critical Care ◽  
Severe Sepsis ◽  
Cd64 Expression ◽  
Kinetics Of ◽  
Critical Care Patients

Blood Cell Separation Device Using Serially Connected Membrane Filters for Adapting to Blood Flow Properties

2009 ◽  
Vol 129 (11) ◽  
pp. 380-386 ◽  
Author(s):  
Taizo Kobayashi ◽  
Daiki Kato ◽  
Hiroyuki Koga ◽  
Kenichi Morimoto ◽  
Makoto Fukuda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Cell Separation ◽  
Flow Properties ◽  
Separation Device ◽  
Membrane Filters

scholarly journals The pathophysiology of “happy” hypoglycemia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Thomas Loeb ◽  
Anna Ozguler ◽  
Geraldine Baer ◽  
Michel Baer
Keyword(s):  
Critical Care ◽  
Hemorrhagic Shock ◽  
Lactate Production ◽  
Severe Hypoglycemia ◽  
Altered Mental Status ◽  
Case Presentation ◽  
Energy Substrate ◽  
Tissue Hypoperfusion ◽  
The Brain ◽  
Critical Care Patients

Abstract Background Hypoglycemia usually includes various neurological symptoms, which are the consequence of neuroglycopenia. When it is severe, it is associated with altered mental status, even coma. Case presentation We report the case of a patient with severe hypoglycemia, completely asymptomatic, due to the increase of lactate production in response to tissue hypoperfusion following a hemorrhagic shock. This illustrates that lactate can substitute glucose as an energy substrate for the brain. It is also a reminder that this metabolite, despite its bad reputation maintained by its role as a marker of severity in critical care patients, has a fundamental role in our metabolism. Conclusions Following the example of the “happy hypoxemia” recently reported in the literature describing asymptomatic hypoxemia in COVID-19 patients, we describe a case of “happy hypoglycemia.”

scholarly journals Microsphere-Based Microfluidic Device for Plasma Separation and Potential Biochemistry Analysis Applications

Micromachines ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 487
Author(s):  
Hongyan Xu ◽  
Zhangying Wu ◽  
Jinan Deng ◽  
Jun Qiu ◽  
Ning Hu ◽  
...  
Keyword(s):  
Blood Sample ◽  
Microfluidic Device ◽  
Biochemical Analysis ◽  
Cost Effective ◽  
Clinical Diagnostics ◽  
Correction Factors ◽  
Separation Device ◽  
Blood Samples ◽  
Plasma Separation ◽  
Blood Biochemical

The development of a simple, portable, and cost-effective plasma separation platform for blood biochemical analysis is of great interest in clinical diagnostics. We represent a plasma separation microfluidic device using microspheres with different sizes as the separation barrier. This plasma separation device, with 18 capillary microchannels, can extract about 3 μL of plasma from a 50 μL blood sample in about 55 min. The effects of evaporation and the microsphere barrier on the plasma biochemical analysis results were studied. Correction factors were applied to compensate for these two effects. The feasibility of the device in plasma biochemical analysis was validated with clinical blood samples.

CD64 expression on monocytes and granulocytes in pediatric acute appendicitis scenario: A pilot study in pediatric critical care

2020 ◽  
Vol 44 (5) ◽  
pp. 315-317
Author(s):  
A. García-Salido ◽  
M. De Lucio-Rodríguez ◽  
J.L. Alonso Calderón ◽  
G. De Lama Caro-Patón ◽  
M. Ramírez-Orellana ◽  
...  
Keyword(s):  
Critical Care ◽  
Pilot Study ◽  
Acute Appendicitis ◽  
Pediatric Critical Care ◽  
Cd64 Expression

scholarly journals Improving glycemic control in critical care patients

2008 ◽  
Vol 3 (4) ◽  
pp. 30-35
Author(s):  
Julie L. Stone ◽  
Linda L. Hutchinson
Keyword(s):  
Critical Care ◽  
Glycemic Control ◽  
Critical Care Patients

Insulin infusion therapy in critical care patients: Regular insulin vs short-acting insulin. A prospective, crossover, randomized, multicenter blind study

2015 ◽  
Vol 30 (2) ◽  
pp. 437.e1-437.e6 ◽  
Author(s):  
Federico Bilotta ◽  
Rafael Badenes ◽  
Simona Lolli ◽  
Francisco Javier Belda ◽  
Sharon Einav ◽  
...  
Keyword(s):  
Critical Care ◽  
Insulin Infusion ◽  
Regular Insulin ◽  
Blind Study ◽  
Infusion Therapy ◽  
Short Acting ◽  
Acting Insulin ◽  
Short Acting Insulin ◽  
Critical Care Patients

scholarly journals Use of methyl-naltrexone for the treatment of opioid-induced constipation in critical care patients

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P486
Author(s):  
SB Sawh ◽  
A Danga ◽  
IP Selveraj ◽  
A Cotton ◽  
PB Patel
Keyword(s):  
Critical Care ◽  
Critical Care Patients
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