Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital

1987 ◽  
Vol 32 (3) ◽  
pp. 273-277 ◽  
Author(s):  
G. Heinemeyer ◽  
H. J. Gramm ◽  
W. Simgen ◽  
R. Dennhardt ◽  
I. Roots
Keyword(s):  
Critical Care ◽  
High Dose ◽  
Kinetics Of ◽  
Critical Care Patients

The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction

1993 ◽  
Vol 45 (5) ◽  
pp. 445-450 ◽  
Author(s):  
G. Heinemeyer ◽  
H. -J. Gramm ◽  
I. Roots ◽  
R. Dennhardt ◽  
W. Simgen
Keyword(s):  
Critical Care ◽  
Renal Dysfunction ◽  
Acute Renal Dysfunction ◽  
Kinetics Of ◽  
Critical Care Patients

Glucocorticoid Rescue for Late-Phase Acute Respiratory Distress Syndrome in Trauma/Surgical Critical Care Patients

2006 ◽  
Vol 72 (7) ◽  
pp. 644-648
Author(s):  
Curt S. Koontz ◽  
K. Kye Higdon ◽  
Troy L. Ploger ◽  
Benjamin W. Dart ◽  
Charles M. Richart ◽  
...  
Keyword(s):  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Critically Ill ◽  
Distress Syndrome ◽  
High Dose ◽  
Surgical Critical Care ◽  
Before And After ◽  
Critical Care Patients

High-dose glucocorticoid therapy (GCT) for the late fibroproliferative phase of acute respiratory distress syndrome (ARDS) is controversial and has shown mixed results in medical patients. No studies have evaluated GCT in trauma/surgical critical care patients. The purpose of this study is to review the outcomes of trauma/surgical critical care patients with refractory ARDS treated with GCT. From January 2001 through September 2005, a pharmacy log was used to identify critically ill trauma/surgical patients in refractory ARDS (7 males and 2 females) who received GCT in an attempt to salvage them. GCT consisted of 200 mg intravenous methylprednisolone bolus for one dose and then 3 mg/kg per day divided every 6 hours for 6 weeks or until weaned off the ventilator. All patients as well as the survivors were analyzed. Outcome data was analyzed with SPSS (Chicago, IL) and the paired sample test. A P value ≤0.05 was considered significant. Data is presented as mean ± standard deviation. The Institutional Review Board approved this retrospective chart review. Seven patients (6 males and 1 female; age, 31 ± 16 years) survived (78%), weaned off of the ventilator, and were discharged from the hospital. The 2 deaths were secondary to refractory respiratory failure as well as cardiac arrest (n = 1) and anoxic brain injury from septic hypotension (n = 1). In survivors (n = 7), hospital length of stay (LOS) and intensive care unit LOS was 71 ± 30 days and 53 ± 16 days, respectively. Duration of GCT administration was 17 ± 6.4 days (range, 11–30 days). Ventilator time before GCT, during GCT, and after GCT was 22 ± 8.4, 15 ± 7.5, and 1.6 ± 6.0 days, respectively. During GCT, 8 patients developed pneumonia, 5 had urinary tract infection, and 3 had bacteremia. All infections were effectively treated with broad-spectrum antibiotics, except in one patient who died of sepsis. PaO2/FIO2 ratio just before and after GCT was 100 ± 36 and 247 ± 56, respectively (n = 7; P < 0.001). Sequential organ failure assessment score just before and after GCT was 9.1 ± 2.3 and 5.0 ± 1.6, respectively (n = 7; P < 0.001). GCT rescue may have a role in salvaging critically ill trauma/surgical critical care patients in late-stage ARDS. More patients, however, need to be studied.

Kinetics of leukocyte CD11b and CD64 expression in severe sepsis and non-infectious critical care patients

2015 ◽  
Vol 59 (7) ◽  
pp. 881-891 ◽  
Author(s):  
J. Jämsä ◽  
V. Huotari ◽  
E.-R. Savolainen ◽  
H. Syrjälä ◽  
T. Ala-kokko
Keyword(s):  
Critical Care ◽  
Severe Sepsis ◽  
Cd64 Expression ◽  
Kinetics Of ◽  
Critical Care Patients

scholarly journals Gentamicin in Hemodialyzed Critical Care Patients: Early Dialysis after Administration of a High Dose Should Be Considered

2012 ◽  
Vol 57 (2) ◽  
pp. 977-982 ◽  
Author(s):  
A. Veinstein ◽  
N. Venisse ◽  
J. Badin ◽  
M. Pinsard ◽  
R. Robert ◽  
...  
Keyword(s):  
Critical Care ◽  
High Dose ◽  
Critical Care Patients

scholarly journals The pathophysiology of “happy” hypoglycemia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Thomas Loeb ◽  
Anna Ozguler ◽  
Geraldine Baer ◽  
Michel Baer
Keyword(s):  
Critical Care ◽  
Hemorrhagic Shock ◽  
Lactate Production ◽  
Severe Hypoglycemia ◽  
Altered Mental Status ◽  
Case Presentation ◽  
Energy Substrate ◽  
Tissue Hypoperfusion ◽  
The Brain ◽  
Critical Care Patients

Abstract Background Hypoglycemia usually includes various neurological symptoms, which are the consequence of neuroglycopenia. When it is severe, it is associated with altered mental status, even coma. Case presentation We report the case of a patient with severe hypoglycemia, completely asymptomatic, due to the increase of lactate production in response to tissue hypoperfusion following a hemorrhagic shock. This illustrates that lactate can substitute glucose as an energy substrate for the brain. It is also a reminder that this metabolite, despite its bad reputation maintained by its role as a marker of severity in critical care patients, has a fundamental role in our metabolism. Conclusions Following the example of the “happy hypoxemia” recently reported in the literature describing asymptomatic hypoxemia in COVID-19 patients, we describe a case of “happy hypoglycemia.”

scholarly journals Improving glycemic control in critical care patients

2008 ◽  
Vol 3 (4) ◽  
pp. 30-35
Author(s):  
Julie L. Stone ◽  
Linda L. Hutchinson
Keyword(s):  
Critical Care ◽  
Glycemic Control ◽  
Critical Care Patients

scholarly journals Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.

1996 ◽  
Vol 184 (2) ◽  
pp. 485-492 ◽  
Author(s):  
M A Alexander-Miller ◽  
G R Leggatt ◽  
A Sarin ◽  
J A Berzofsky
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocyte ◽  
Target Cells ◽  
High Dose ◽  
High Avidity ◽  
Apoptotic Pathway ◽  
Peptide Antigen ◽  
Kinetics Of ◽  
Selection Of

Experimental data suggest that negative selection of thymocytes can occur as a result of supraoptimal antigenic stimulation. It is unknown, however, whether such mechanisms are at work in mature CD8+ T lymphocytes. Here, we show that CD8+ effector cytotoxic T lymphocytes (CTL) are susceptible to proliferative inhibition by high dose peptide antigen, leading to apoptotic death mediated by TNF-alpha release. Such inhibition is not reflected in the cytolytic potential of the CTL, since concentrations of antigen that are inhibitory for proliferation promote efficient lysis of target cells. Thus, although CTL have committed to the apoptotic pathway, the kinetics of this process are such that CTL function can occur before death of the CTL. The concentration of antigen required for inhibition is a function of the CTL avidity, in that concentrations of antigen capable of completely inhibiting high avidity CTL maximally stimulate low avidity CTL. Importantly, the inhibition can be detected in both activated and resting CTL. Blocking studies demonstrate that the CD8 molecule contributes significantly to the inhibitory signal as the addition of anti-CD8 antibody restores the proliferative response. Thus, our data support the model that mature CD8+ CTL can accommodate an activation signal of restricted intensity, which, if surpassed, results in deletion of that cell.

Insulin infusion therapy in critical care patients: Regular insulin vs short-acting insulin. A prospective, crossover, randomized, multicenter blind study

2015 ◽  
Vol 30 (2) ◽  
pp. 437.e1-437.e6 ◽  
Author(s):  
Federico Bilotta ◽  
Rafael Badenes ◽  
Simona Lolli ◽  
Francisco Javier Belda ◽  
Sharon Einav ◽  
...  
Keyword(s):  
Critical Care ◽  
Insulin Infusion ◽  
Regular Insulin ◽  
Blind Study ◽  
Infusion Therapy ◽  
Short Acting ◽  
Acting Insulin ◽  
Short Acting Insulin ◽  
Critical Care Patients
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