scholarly journals Electrophysiological Source Imaging of Brain Networks Perturbed by Low-Intensity Transcranial Focused Ultrasound

2016 ◽  
Vol 63 (9) ◽  
pp. 1787-1794 ◽  
Author(s):  
Kai Yu ◽  
Abbas Sohrabpour ◽  
Bin He
Keyword(s):  
Focused Ultrasound ◽  
Brain Networks ◽  
Source Imaging ◽  
Low Intensity ◽  
Transcranial Focused Ultrasound

scholarly journals A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease

2021 ◽  
Author(s):  
Hyeonseok Jeong ◽  
Jooyeon Jamie Im ◽  
Jong-Sik Park ◽  
Seung-Hee Na ◽  
Wonhye Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Pilot Clinical Study ◽  
Transcranial Focused Ultrasound

Implication of Auditory Confounding in Interpreting Somatosensory and Motor Responses in Low-Intensity Transcranial Focused Ultrasound Stimulation

2021 ◽  
Author(s):  
Christine Park ◽  
Mengyue Chen ◽  
Taewon Kim
Keyword(s):  
Focused Ultrasound ◽  
Auditory Pathway ◽  
Localization Accuracy ◽  
Motor Responses ◽  
Non Invasive ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Transcranial Focused Ultrasound ◽  
Indirect Stimulation ◽  
Stimulation Of

Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a non-invasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous studies in animals and humans acknowledged the possibility of indirect stimulation of the peripheral auditory pathway that could confound the somatosensory and motor responses observed with LI-tFUS stimulation. Here, we discuss the implications and interpretations of auditory confounding in the context of neuromodulation.

scholarly journals Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-related Cortical Activity in Humans

2020 ◽  
Author(s):  
Kai Yu ◽  
Chang Liu ◽  
Xiaodan Niu ◽  
Bin He
Keyword(s):  
Voluntary Movement ◽  
Focused Ultrasound ◽  
Human Subjects ◽  
Pulse Repetition Frequency ◽  
Cortical Activity ◽  
Source Imaging ◽  
Source Profile ◽  
Profile Amplitude ◽  
The Brain ◽  
Transcranial Focused Ultrasound

AbstractTranscranial focused ultrasound (tFUS) is an emerging non-invasive brain stimulation tool for safely and reversibly modulating brain circuits. The effectiveness of tFUS on human brain has been demonstrated, but how tFUS influences the human voluntary motor processing in the brain remains unclear. We apply low-intensity tFUS to modulate the movement-related cortical potential (MRCP) originating from human subjects practicing a voluntary foot tapping task. 64-channel electroencephalograph (EEG) is recorded concurrently and further used to reconstruct the brain source activity specifically at the primary leg motor cortical area using the electrophysiological source imaging (ESI). The ESI illustrates the ultrasound modulated MRCP source dynamics with high spatiotemporal resolutions. The MRCP source is imaged and its source profile is further evaluated for assessing the tFUS neuromodulatory effects on the voluntary MRCP. Moreover, the effect of ultrasound pulse repetition frequency (UPRF) is further assessed in modulating the MRCP. ESI results show that tFUS significantly increases the MRCP source profile amplitude (MSPA) comparing to a sham ultrasound condition, and further, a high UPRF enhances the MSPA more than a low UPRF. This work provides the first evidence of tFUS enhancing the human voluntary movement-related cortical activity through excitatory modulation.

scholarly journals Safety of transcranial focused ultrasound for human neuromodulation

2018 ◽  
Author(s):  
Wynn Legon ◽  
Priya Bansal ◽  
Leo Ai ◽  
Jerel K. Mueller ◽  
Gregg Meekins ◽  
...  
Keyword(s):  
Neck Pain ◽  
Focused Ultrasound ◽  
Neuronal Excitability ◽  
Acoustic Energy ◽  
Full Potential ◽  
University Of Minnesota ◽  
Serious Adverse Events ◽  
Low Intensity ◽  
Transcranial Focused Ultrasound

AbstractBackgroundLow intensity transcranial focused ultrasound (tFUS) is a new method of non-invasive neuromodulation that uses acoustic energy to affect neuronal excitability. tFUS offers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full potential of low intensity ultrasound for research and clinical application can be investigated, data on the safety of this technique is indicated.Objective/HypothesisTo provide an initial evaluation of the safety of tFUS for human neuromodulation through participant report and neurological assessment surrounding pilot investigation of tFUS for neuromodulation.MethodsParticipants (N = 120) that were enrolled in one of seven human ultrasound neuromodulation studies at the University of Minnesota (2015 – 2017) were queried to complete a follow-up Participant Report of Symptoms questionnaire assessing their self-reported experience and tolerance to participation in tFUS research and the perceived relation of symptoms to tFUS.ResultsA total of 64/120 participant (53%) responded to follow-up requests to complete the Participant Report of Symptoms questionnaire. During the conduct of the seven studies in this report, none of the participants experienced serious adverse effects. From the post-hoc assessment of safety using the questionnaire, 7/64 reported mild to moderate symptoms, that were perceived as ‘possibly’ or ‘probably’ related to participation in tFUS experiments. These reports included neck pain, problems with attention, muscle twitches and anxiety. The most common unrelated symptoms included sleepiness and neck pain. There were initial transient reports of mild neck pain, scalp tingling and headache that were extinguished upon follow-up. No new symptoms were reported upon follow up out to 1 month.Conclusions(s)To date, in the literature and including this report, no serious adverse events have been reported as a result of low intensity tFUS for human neuromodulation. Here, we report new data on minor transient events. As currently employed with the parameters used in the studies in this report, tFUS looks to be a safe form of transient neuromodulation in humans.

Sign in / Sign up

Export Citation Format

Share Document