Diffuser-Aided Diffuse Optical Imaging for Breast Tumor: A Feasibility Study Based on Time-Resolved Three-Dimensional Monte Carlo Modeling

2012 ◽  
Vol 59 (5) ◽  
pp. 1454-1461 ◽  
Author(s):  
Ching-Cheng Chuang ◽  
Chia-Yen Lee ◽  
Chung-Ming Chen ◽  
Yao-Sheng Hsieh ◽  
Tsan-Chi Liu ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Optical Imaging ◽  
Feasibility Study ◽  
Breast Tumor ◽  
Three Dimensional ◽  
Diffuse Optical Imaging ◽  
Monte Carlo Modeling ◽  
Time Resolved

scholarly journals Accelerating Monte Carlo modeling of structured-light-based diffuse optical imaging via “photon sharing”

2020 ◽  
Vol 45 (10) ◽  
pp. 2842 ◽  
Author(s):  
Shijie Yan ◽  
Ruoyang Yao ◽  
Xavier Intes ◽  
Qianqian Fang
Keyword(s):  
Monte Carlo ◽  
Optical Imaging ◽  
Structured Light ◽  
Diffuse Optical Imaging ◽  
Monte Carlo Modeling

Study on dynamics of photon migration in human breast based on three-dimensional Monte Carlo modeling

2010 ◽  
Author(s):  
Ching-Cheng Chuang ◽  
Chung-Ming Chen ◽  
Chia-Yen Lee ◽  
Jui-che Tsai ◽  
Chih-Wei Lu ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Three Dimensional ◽  
Photon Migration ◽  
Human Breast ◽  
Monte Carlo Modeling

Monte Carlo modeling of time-resolved near-infrared transillumination of human breast tissue

1994 ◽  
Author(s):  
Oliver Schuetz ◽  
Hans-Erich Reinfelder ◽  
Klaus W. Klingenbeck-Regn ◽  
Hartmut Bartelt
Keyword(s):  
Monte Carlo ◽  
Breast Tissue ◽  
Near Infrared ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Monte Carlo Modeling ◽  
Time Resolved

scholarly journals In Vivo Resolution of Multiexponential Decays of Multiple Near-Infrared Molecular Probes by Fluorescence Lifetime-Gated Whole-Body Time-Resolved Diffuse Optical Imaging

2007 ◽  
Vol 6 (4) ◽  
pp. 7290.2007.00020 ◽  
Author(s):  
Walter Akers ◽  
Frederic Lesage ◽  
Dewey Holten ◽  
Samuel Achilefu
Keyword(s):  
Optical Imaging ◽  
Fluorescence Lifetime ◽  
Fluorescence Intensity ◽  
Near Infrared ◽  
Molecular Probes ◽  
Whole Body ◽  
Diffuse Optical Imaging ◽  
Fluorescence Lifetimes ◽  
Time Resolved

The biodistribution of two near-infrared fluorescent agents was assessed in vivo by time-resolved diffuse optical imaging. Bacteriochlorophyll a (BC) and cypate-glysine-arginine-aspartic acid-serine-proline-lysine-OH (Cyp-GRD) were administered separately or combined to mice with subcutaneous xenografts of human breast adenocarcinoma and slow-release estradiol pellets for improved tumor growth. The same excitation (780 nm) and emission (830 nm) wavelengths were used to image the distinct fluorescence lifetime distribution of the fluorescent molecular probes in the mouse cancer model. Fluorescence intensity and lifetime maps were reconstructed after raster-scanning whole-body regions of interest by time-correlated single-photon counting. Each captured temporal point-spread function (TPSF) was deconvolved using both a single and a multiexponental decay model to best determine the measured fluorescence lifetimes. The relative signal from each fluorophore was estimated for any region of interest included in the scanned area. Deconvolution of the individual TPSFs from whole-body fluorescence intensity scans provided corresponding lifetime images for comparing individual component biodistribution. In vivo fluorescence lifetimes were determined to be 0.8 ns (Cyp-GRD) and 2 ns (BC). This study demonstrates that the relative biodistribution of individual fluorophores with similar spectral characteristics can be compartmentalized by using the time-domain fluorescence lifetime gating method.

Breast Monitoring by Time-Resolved Diffuse Optical Imaging

2015 ◽  
pp. 587-611 ◽  
Author(s):  
Giovanna Quarto ◽  
Alessandro Torricelli ◽  
Lorenzo Spinelli ◽  
Antonio Pifferi ◽  
Rinaldo Cubeddu ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Diffuse Optical Imaging ◽  
Time Resolved

scholarly journals Three-dimensional Monte Carlo modeling of laser-tissue interaction

1999 ◽  
Author(s):  
Beop-Min Kim ◽  
Nicholas A. Gentile ◽  
Kenneth B. Trauner ◽  
Richard A. London
Keyword(s):  
Monte Carlo ◽  
Three Dimensional ◽  
Monte Carlo Modeling ◽  
Tissue Interaction ◽  
Laser Tissue Interaction
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