In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes

J.D. Weiland; D.J. Anderson; M.S. Humayun

doi:10.1109/tbme.2002.805487

In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes

IEEE Transactions on Biomedical Engineering ◽

10.1109/tbme.2002.805487 ◽

2002 ◽

Vol 49 (12) ◽

pp. 1574-1579 ◽

Cited By ~ 250

Author(s):

J.D. Weiland ◽

D.J. Anderson ◽

M.S. Humayun

Keyword(s):

Electrical Properties ◽

Titanium Nitride ◽

Iridium Oxide ◽

Stimulating Electrodes

Download Full-text

In vitro comparison of sputtered iridium oxide and platinum-coated neural implantable microelectrode arrays

Biomedical Materials ◽

10.1088/1748-6041/5/1/015007 ◽

2010 ◽

Vol 5 (1) ◽

pp. 015007 ◽

Cited By ~ 111

Author(s):

S Negi ◽

R Bhandari ◽

L Rieth ◽

F Solzbacher

Keyword(s):

Microelectrode Arrays ◽

Iridium Oxide ◽

In Vitro Comparison

Download Full-text

Development of Titanium Needle Probes for Neural Recording and Evaluation of Magnetic Resonance Imaging Artifacts

Journal of Nanotechnology in Engineering and Medicine ◽

10.1115/1.4000039 ◽

2009 ◽

Vol 1 (1) ◽

Cited By ~ 4

Author(s):

Hargsoon Yoon ◽

Devesh C. Deshpande ◽

T. H. Kim ◽

Eun-Kee Jeong ◽

Robert E. Harbaugh ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Microelectrode Array ◽

Neural Recording ◽

Iridium Oxide ◽

Resonance Imaging ◽

Needle Probe ◽

Imaging Artifacts ◽

Neural Probe

The aim of this research is to develop a mechanically flexible and strong neural probe with microelectrode array for future clinical applications in neural prosthetics and neurological disorder fields. This research specifically focuses on the development of neural recording electrodes with iridium oxide (IrOx) electrodes on a titanium needle probe and discusses the fabrication techniques and their evaluation for physical properties and electrochemical performance. Microfabrication processes, such as inductive coupled plasma etching, were used to deeply etch the Ti needle structures on titanium foils, and microelectrode arrays with iridium oxide films were formed by electrochemical deposition for low impedance neural recording. Mechanical and electrochemical analyses were performed to verify the viability of Ti needle probes in vitro. The final section of this paper addresses the issue of magnetic resonance imaging artifacts of titanium needle probes, and test results are compared with similarly fabricated Si needle probes. The advantages of using a titanium needle probe are discussed in the application of neural probe electrodes, as well.

Download Full-text

Nasal drug delivery: An in vitro characterization of transepithelial electrical properties and fluxes in the presence or absence of enhancers

Journal of Controlled Release ◽

10.1016/0168-3659(88)90043-0 ◽

1988 ◽

Vol 8 (2) ◽

pp. 167-177 ◽

Cited By ~ 44

Author(s):

M.A. Wheatley ◽

J. Dent ◽

E.B. Wheeldon ◽

P.L. Smith

Keyword(s):

Drug Delivery ◽

Electrical Properties ◽

Nasal Drug Delivery ◽

In Vitro Characterization

Download Full-text

In Vitro Electrochemical Properties of Titanium Nitride Neural Stimulating and Recording Electrodes as a Function of Film Thickness and Voltage Biasing

10.1109/embc46164.2021.9630715 ◽

2021 ◽

Author(s):

Justin R. Abbott ◽

Alexandra Joshi-Imre ◽

Stuart F. Cogan

Keyword(s):

Film Thickness ◽

Titanium Nitride ◽

Electrochemical Properties ◽

Recording Electrodes

Download Full-text

A Comparison of TiN, Iridium and Iridium Oxide Stimulating Electrodes for Neural Stimulation

Biomedical Engineering / 765: Telehealth / 766: Assistive Technologies ◽

10.2316/p.2012.764-178 ◽

2012 ◽

Cited By ~ 3

Author(s):

Naser Pour Aryan ◽

Christian Brendler ◽

Viola Rieger ◽

Steffen Kibbel ◽

Alex Harscher ◽

...

Keyword(s):

Iridium Oxide ◽

Neural Stimulation ◽

Stimulating Electrodes

Download Full-text

IN VITRO AND IN VIVO LINEAR A C POLARIZATION IMPEDANCE STUDIES ON POROUS STIMULATING ELECTRODES

Proceedings of the Fifth New England Bioengineering Conference ◽

10.1016/b978-0-08-021937-0.50058-2 ◽

1977 ◽

pp. 265-269

Author(s):

B.N. Hung ◽

R.B. Beard ◽

M. Brownstein ◽

H. Carim ◽

S.E. Dubin ◽

...

Keyword(s):

Polarization Impedance ◽

Stimulating Electrodes

Download Full-text

Effect of calcium on ion transport and electrical properties of tracheal epithelium

Journal of Applied Physiology ◽

10.1152/jappl.1978.44.6.900 ◽

1978 ◽

Vol 44 (6) ◽

pp. 900-904 ◽

Cited By ~ 11

Author(s):

M. G. Marin ◽

M. M. Zaremba

Keyword(s):

Electrical Properties ◽

Ion Transport ◽

Calcium Concentration ◽

Short Circuit ◽

Electrical Potential ◽

Short Circuit Current ◽

Tracheal Epithelium ◽

Electrical Potential Difference ◽

Tracheal Lumen

Active transport of Cl- toward the tracheal lumen and Na+ away from the lumen creates an electrical potential difference across dog tracheal epithelium. This study examined in vitro the effect of varying calcium concentration in the bathing media on the ion transport and electrical properties of dog tracheal epithelium. In six pairs of epithelia, changing calcium concentration from 1.9 to 0 mM resulted in a significant decrease in electrical resistance, from 318 +/- 36 to 214 +/- 24 omega.cm2. Short-circuit current and net Cl- and Na+ fluxes measured under short-circuit conditions were not changed significantly. Changing calcium concentration from 1.9 to 10 mM resulted in no significant change from control in the electrical properties nor in net Cl- and Na+ fluxes (short-circuit conditions). Histamine (10(-4) M) produced a significantly smaller increase in short-circuit current in 0 than in 1.9 mM Ca2+ (+5 +/- 2 vs. +12 +/- 2 microamperemeter/cm2). However, electrical changes were not significantly different in 1 or 10 mM Ca2+. These results indicate that calcium lack increased permeability of tracheal epithelium and that the increase in short-circuit current due to histamine depended in part on calcium.

Download Full-text